Locked nucleic acids (LNA): A promising molecular family for gene-function analysis and antisense drug development

H. Ørum, J. Wengel

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

    Abstrakt

    Locked nucleic acids (LNAs) are a family of conformationally locked oligonucleotide analogs inducing unprecedented binding affinity towards DNA/RNA target sequences. Importantly, by virtue of the structural resemblance of LNAs to natural nucleic acid monomers, a combination of LNA chemistry with other oligonucleotide chemistries can be exploited to fine-tune the properties towards optimized antisense drug development and target validation technology. The first promising antisense results from experiments with LNA in living animals are described.

    OriginalsprogEngelsk
    TidsskriftCurrent Opinion in Molecular Therapeutics
    Vol/bind3
    Udgave nummer3
    Sider (fra-til)239-243
    ISSN1464-8431
    StatusUdgivet - 2001

      Fingerprint

    Citationsformater