Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers

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Abstrakt

Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has received substantial attention and has become a significant tool within chemical biology disciplines like molecular biology research, diagnostics and therapeutic development. However, despite their obvious structurally unique properties, LNA-based aptamers for diagnostic and therapeutic applications remain largely unexplored. Future evolution of LNAoligonucleotideaptamers will depend on scientific breakthroughs relating to enzymatic polymerization using LNAnucleoside triphosphates as substrates. Herein, we highlight recent developments in this direction using various polymerases.
OriginalsprogEngelsk
TidsskriftMolecular BioSystems
Vol/bind5
Udgave nummer8
Sider (fra-til)787-792
Antal sider6
ISSN1742-206X
DOI
StatusUdgivet - 2009

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