Liraglutide treatment is associated with progression of coronary artery fibrous plaque: a prospective 1-year follow-up study in asymptomatic patients with type 2 diabetes

Laurits Juhl Heinsen*, Gokulan Pararajasingam, Thomas Rueskov Andersen, Søren Auscher, Hussam Mahmoud Sheta, Helle Precht, Kalle Brunebjerg Engdam, Jørgen Hangaard, Jess Lambrechtsen, Filip Krag Knop, Kenneth Egstrup

*Kontaktforfatter

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Abstract

Objective: The objective of this study was to assess the association between clinically indicated liraglutide treatment and coronary artery plaque progression during 1-year follow-up in asymptomatic diabetes. Methods: Patients were divided into a group receiving liraglutide (Lira+) and a group not receiving liraglutide (Lira-). Coronary computed tomography angiography (CCTA) was performed to assess total atheroma volume (TAV) and subtypes of plaque volumes (dense calcium, fibrous, fibrous-fatty, and necrotic core plaque) and the plaque progression during one year follow-up. Results: Fifty-five patients (27%) receiving liraglutide and 149 (73%) how did not were included. Changes in TAV during 1-year of follow-up were similar in the two groups (38 ± 180 (Lira+) vs. -1 ± 160 mm3 (Lira-), P = 0.13). A greater increase in fibrous plaque volume was seen in the Lira + vs. the Lira- group (34 ± 129 vs. -2 ± 101 mm3, P = 0.04). Changes over 1-year in the other plaque subtypes were similar in the two groups. Treatment duration of liraglutide was not associated with changes in TAV. Conclusion: In patients with T2D without known prior coronary artery disease, liraglutide treatment was associated with a significant increase in coronary artery fibrous plaque volume during 1-year follow-up.

OriginalsprogEngelsk
Artikelnummer214
TidsskriftBMC Cardiovascular Disorders
Vol/bind23
Antal sider8
ISSN1471-2261
DOI
StatusUdgivet - 28. apr. 2023

Bibliografisk note

Funding Information:
This study was funded by grants from the Region of Southern Denmark, the University of Southern Denmark, and the Cardiovascular Research Unit at Odense University Hospital Svendborg.

Funding Information:
The authors are grateful for the support from the entire staff of Cardiovascular Research Unit and the CT-radiographers from the Department of Radiology, Odense University Hospital Svendborg, Denmark. The authors are grateful to the participants volunteering for the study, thereby allowing to further advance our understanding of atherosclerotic disease in asymptomatic diabetes.

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