Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)

Goran N Kaluđerović; Andrea Dietrich; Harish Kommera; Judith Kuntsche; Karsten Mäder; Thomas Mueller; Reinhard Paschke

doi:10.1016/j.ejmech.2012.06.004

Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)

Goran N Kaluđerović, Andrea Dietrich, Harish Kommera, Judith Kuntsche, Karsten Mäder, Thomas Mueller, Reinhard Paschke

Institut for Fysik, Kemi og Farmaci

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Formulation of liposome delivery system loaded with water insoluble 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II), LipoTHP-C11 was carried out. The particle size distributions were determined by dynamic light scattering and asymmetrical flow field-flow fractionation indicating size of around 120 nm. Stability study showed that LipoTHP-C11 was stable at 4 °C for more than two months. To test suitability of chosen formulation, LipoTHP-C11 was investigated against several tumor cell lines: H12.1, 1411HP, 518A2, A549, HT-29, MCF-7 and SW1736. Furthermore, toxicity against normal fibroblasts was examined. LipoTHP-C11 may be used as an attractive candidate for further assessment in vivo as antitumor agent.

Originalsprog	Engelsk
Tidsskrift	European Journal of Medicinal Chemistry
Vol/bind	54
Sider (fra-til)	567-572
ISSN	0223-5234
DOI	https://doi.org/10.1016/j.ejmech.2012.06.004
Status	Udgivet - 2012

Dokumenter og links

10.1016/j.ejmech.2012.06.004

Citationsformater

@article{54368b28d76e43e5a7f464923789e0dc,

title = "Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)",

abstract = "Formulation of liposome delivery system loaded with water insoluble 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II), LipoTHP-C11 was carried out. The particle size distributions were determined by dynamic light scattering and asymmetrical flow field-flow fractionation indicating size of around 120 nm. Stability study showed that LipoTHP-C11 was stable at 4 °C for more than two months. To test suitability of chosen formulation, LipoTHP-C11 was investigated against several tumor cell lines: H12.1, 1411HP, 518A2, A549, HT-29, MCF-7 and SW1736. Furthermore, toxicity against normal fibroblasts was examined. LipoTHP-C11 may be used as an attractive candidate for further assessment in vivo as antitumor agent.",

keywords = "Antineoplastic Agents, Cell Line, Tumor, Humans, Inhibitory Concentration 50, Liposomes, Organoplatinum Compounds, Solubility, Water",

author = "Kalu{\d}erovi{\'c}, {Goran N} and Andrea Dietrich and Harish Kommera and Judith Kuntsche and Karsten M{\"a}der and Thomas Mueller and Reinhard Paschke",

year = "2012",

doi = "10.1016/j.ejmech.2012.06.004",

language = "English",

volume = "54",

pages = "567--572",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson",

}

Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II). / Kaluđerović, Goran N; Dietrich, Andrea; Kommera, Harish et al.
I: European Journal of Medicinal Chemistry, Bind 54, 2012, s. 567-572.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Liposomes as vehicles for water insoluble platinum-based potential drug

T2 - 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)

AU - Kaluđerović, Goran N

AU - Dietrich, Andrea

AU - Kommera, Harish

AU - Kuntsche, Judith

AU - Mäder, Karsten

AU - Mueller, Thomas

AU - Paschke, Reinhard

PY - 2012

Y1 - 2012

N2 - Formulation of liposome delivery system loaded with water insoluble 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II), LipoTHP-C11 was carried out. The particle size distributions were determined by dynamic light scattering and asymmetrical flow field-flow fractionation indicating size of around 120 nm. Stability study showed that LipoTHP-C11 was stable at 4 °C for more than two months. To test suitability of chosen formulation, LipoTHP-C11 was investigated against several tumor cell lines: H12.1, 1411HP, 518A2, A549, HT-29, MCF-7 and SW1736. Furthermore, toxicity against normal fibroblasts was examined. LipoTHP-C11 may be used as an attractive candidate for further assessment in vivo as antitumor agent.

AB - Formulation of liposome delivery system loaded with water insoluble 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II), LipoTHP-C11 was carried out. The particle size distributions were determined by dynamic light scattering and asymmetrical flow field-flow fractionation indicating size of around 120 nm. Stability study showed that LipoTHP-C11 was stable at 4 °C for more than two months. To test suitability of chosen formulation, LipoTHP-C11 was investigated against several tumor cell lines: H12.1, 1411HP, 518A2, A549, HT-29, MCF-7 and SW1736. Furthermore, toxicity against normal fibroblasts was examined. LipoTHP-C11 may be used as an attractive candidate for further assessment in vivo as antitumor agent.

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Humans

KW - Inhibitory Concentration 50

KW - Liposomes

KW - Organoplatinum Compounds

KW - Solubility

KW - Water

U2 - 10.1016/j.ejmech.2012.06.004

DO - 10.1016/j.ejmech.2012.06.004

M3 - Journal article

C2 - 22749394

SN - 0223-5234

VL - 54

SP - 567

EP - 572

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)

Abstract

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