Lipid molecular timeline profiling reveals diurnal crosstalk between the liver and circulation

Richard R. Sprenger, Martin Hermansson, Ditte Neess, Lena Sokol Becciolini, Signe Bek Sørensen, Rolf Fagerberg, Josef Ecker, Gerhard Liebisch, Ole N. Jensen, Dennis E. Vance, Nils J. Færgeman, Robin W. Klemm, Christer S. Ejsing*

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Abstrakt

Diurnal regulation of whole-body lipid metabolism plays a vital role in metabolic health. Although changes in lipid levels across the diurnal cycle have been investigated, the system-wide molecular responses to both short-acting fasting-feeding transitions and longer-timescale circadian rhythms have not been explored in parallel. Here, we perform time-series multi-omics analyses of liver and plasma revealing that the majority of molecular oscillations are entrained by adaptations to fasting, food intake, and the postprandial state. By developing algorithms for lipid structure enrichment analysis and lipid molecular crosstalk between tissues, we find that the hepatic phosphatidylethanolamine (PE) methylation pathway is diurnally regulated, giving rise to two pools of oscillating phosphatidylcholine (PC) molecules in the circulation, which are coupled to secretion of either very low-density lipoprotein (VLDL) or high-density lipoprotein (HDL) particles. Our work demonstrates that lipid molecular timeline profiling across tissues is key to disentangling complex metabolic processes and provides a critical resource for the study of whole-body lipid metabolism.
OriginalsprogEngelsk
Artikelnummer108710
TidsskriftCell Reports
Vol/bind34
Udgave nummer5
Antal sider23
ISSN2211-1247
DOI
StatusUdgivet - 2. feb. 2021

Bibliografisk note

Funding Information:
We thank Alba Diz-Muñoz, Sabbi Lall, Nils Hoffmann, and Robert Ahrends for constructive comments and Peter Højrup for amino acid analysis. This research was supported by the VILLUM Foundation ( VKR023439 to C.S.E.), the VILLUM Center for Bioanalytical Sciences ( VKR023179 to O.N.J. and C.S.E.), and the Lundbeckfonden ( R44-A4342 and R54-A5858 to C.S.E.). The research leading to these results has received funding from the European Union Seventh Framework Programme ( FP7-2007-2013 ) under grant agreement “HEALTH-F2-2013-602222 (Athero-Flux)” (O.N.J. and C.S.E.).

Publisher Copyright:
© 2021 The Author(s)

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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