Lipid-lowering treatment to the end? A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds

Line Kirkeby Petersen, Kaare Christensen, Jakob Kragstrup

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

People aged 80 or older are the fastest growing population in high-income countries. One of the most common causes of death among the elderly is the cardiovascular disease (CVD). Lipid-lowering treatment is common, e.g. one-third of 75-84-year-old Swedes are treated with statins. The assumption that hypercholesterolaemia is a risk factor at the highest ages seems to be based on extrapolation from younger adults. A review of observational studies shows a trend where all-cause mortality was highest when total cholesterol (TC) was lowest ('a reverse J-shaped' association between TC and all-cause mortality). Low TC (
OriginalsprogEngelsk
TidsskriftAge and Ageing
Vol/bind39
Udgave nummer6
Sider (fra-til)674-80
Antal sider7
ISSN0002-0729
DOI
StatusUdgivet - 1. nov. 2010

Fingeraftryk

Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia
Young Adult
Cause of Death

Citer dette

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Lipid-lowering treatment to the end? A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds. / Petersen, Line Kirkeby; Christensen, Kaare; Kragstrup, Jakob.

I: Age and Ageing, Bind 39, Nr. 6, 01.11.2010, s. 674-80.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Christensen, Kaare

AU - Kragstrup, Jakob

PY - 2010/11/1

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