Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study

Mel C Heeran, Claus K Høgdall, Susanne K Kjaer, Lise Christensen, Jan Blaakaer, Ib Jarle Christensen, Estrid V S Hogdall

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Abstrakt

The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays (TA), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours (BOT) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut-off level for cyclin E overexpression, 20% of the BOTs were positive with a higher proportion of serous than mucinous tumours. Sixty-two per cent of the OCs were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.

OriginalsprogEngelsk
TidsskriftA P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica (Online)
Vol/bind120
Udgave nummer10
Sider (fra-til)846-854
ISSN1600-0463
DOI
StatusUdgivet - 2012
Udgivet eksterntJa

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