Lifelong physical activity preserves functional sympatholysis and purinergic signalling in the ageing human leg

Stefan Mortensen, M Nyberg, K Winding, B Saltin

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Ageing is associated with an impaired ability to modulate sympathetic vasoconstrictor activity (functional sympatholysis) and a reduced exercise hyperaemia. The purpose of this study was to investigate whether a physically active lifestyle can offset the impaired functional sympatholysis and exercise hyperaemia in the leg and whether ATP signalling is altered by ageing and physical activity. Leg haemodynamics, interstitial [ATP] and P2Y(2) receptor content was determined in eight young (23 ± 1 years), eight lifelong sedentary elderly (66 ± 2 years) and eight lifelong active elderly (62 ± 2 years) men at rest and during one-legged knee extensions (12 W and 45% maximal workload (WL(max))) and arterial infusion of ACh and ATP with and without tyramine. The vasodilatory response to ACh was lowest in the sedentary elderly, higher in active elderly (P
OriginalsprogEngelsk
TidsskriftJournal of Physiology
Vol/bind590
Udgave nummerPt 23
Sider (fra-til)6227-36
Antal sider10
ISSN0022-3751
DOI
StatusUdgivet - 1. dec. 2012
Udgivet eksterntJa

Fingeraftryk Dyk ned i forskningsemnerne om 'Lifelong physical activity preserves functional sympatholysis and purinergic signalling in the ageing human leg'. Sammen danner de et unikt fingeraftryk.

Citationsformater