Lifelong football training

Effects on autophagy and healthy longevity promotion

Annamaria Mancini*, Daniela Vitucci, Morten Bredsgaard Randers, Jakob Friis Schmidt, Marie Hagman, Thomas Rostgaard Andersen, Esther Imperlini, Annalisa Mandola, Stefania Orru, Peter Krustrup, Pasqualina Buono

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Resumé

Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.

OriginalsprogEngelsk
Artikelnummer132
TidsskriftFrontiers in Physiology
Vol/bind10
ISSN1664-042X
DOI
StatusUdgivet - 1. feb. 2019

Fingeraftryk

Football
Skeletal Muscle
Proteasome Endopeptidase Complex
Exercise
Physiological Phenomena
Health Promotion
Proteolysis
Muscles
Growth
Proteins

Citer dette

Mancini, Annamaria ; Vitucci, Daniela ; Randers, Morten Bredsgaard ; Schmidt, Jakob Friis ; Hagman, Marie ; Andersen, Thomas Rostgaard ; Imperlini, Esther ; Mandola, Annalisa ; Orru, Stefania ; Krustrup, Peter ; Buono, Pasqualina. / Lifelong football training : Effects on autophagy and healthy longevity promotion. I: Frontiers in Physiology. 2019 ; Bind 10.
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title = "Lifelong football training: Effects on autophagy and healthy longevity promotion",
abstract = "Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.",
keywords = "Autophagy, Cardiovascular capacity, Football, Lifelong training, Longevity",
author = "Annamaria Mancini and Daniela Vitucci and Randers, {Morten Bredsgaard} and Schmidt, {Jakob Friis} and Marie Hagman and Andersen, {Thomas Rostgaard} and Esther Imperlini and Annalisa Mandola and Stefania Orru and Peter Krustrup and Pasqualina Buono",
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Mancini, A, Vitucci, D, Randers, MB, Schmidt, JF, Hagman, M, Andersen, TR, Imperlini, E, Mandola, A, Orru, S, Krustrup, P & Buono, P 2019, 'Lifelong football training: Effects on autophagy and healthy longevity promotion', Frontiers in Physiology, bind 10, 132. https://doi.org/10.3389/fphys.2019.00132

Lifelong football training : Effects on autophagy and healthy longevity promotion. / Mancini, Annamaria; Vitucci, Daniela; Randers, Morten Bredsgaard; Schmidt, Jakob Friis; Hagman, Marie; Andersen, Thomas Rostgaard; Imperlini, Esther; Mandola, Annalisa; Orru, Stefania; Krustrup, Peter; Buono, Pasqualina.

I: Frontiers in Physiology, Bind 10, 132, 01.02.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Lifelong football training

T2 - Effects on autophagy and healthy longevity promotion

AU - Mancini, Annamaria

AU - Vitucci, Daniela

AU - Randers, Morten Bredsgaard

AU - Schmidt, Jakob Friis

AU - Hagman, Marie

AU - Andersen, Thomas Rostgaard

AU - Imperlini, Esther

AU - Mandola, Annalisa

AU - Orru, Stefania

AU - Krustrup, Peter

AU - Buono, Pasqualina

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.

AB - Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.

KW - Autophagy

KW - Cardiovascular capacity

KW - Football

KW - Lifelong training

KW - Longevity

U2 - 10.3389/fphys.2019.00132

DO - 10.3389/fphys.2019.00132

M3 - Journal article

VL - 10

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 132

ER -