Life expectancy of HIV-infected patients followed at the largest hospital in Guinea-Bissau is one-fourth of life expectancy of the background population

Thomas Engell-Sørensen*, Andreas Rieckmann, Candida Medina, David da Silva Té, Amabelia Rodrigues, Ane Bærent Fisker, Peter Aaby, Christian Erikstrup, Sanne Jespersen, Christian Wejse, Bo Langhoff Hønge, Bissau HIV Cohort Study Group, Peter Aaby (Medlem af forfattergruppering)


Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Purpose: To estimate the life expectancy (LE) of HIV-infected patients in the West African country Guinea-Bissau and compare it with the background population. Methods: Using data from the largest HIV outpatient clinic at the Hospital Nacional Simão Mendes in the capital Bissau, a retrospective observational cohort study was performed. The study included patients attending the clinic between June 2005 and January 2018. A total of 8958 HIV-infected patients were included. In the analysis of the background population, a total of 109,191 people were included. LE incorporating loss to follow-up (LTFU) was estimated via Kaplan–Meier estimators using observational data on adult HIV-infected patients and background population. Results: The LE of 20-year-old HIV-infected patients was 9.8 years (95% CI 8.3–11.5), corresponding to 22.3% (95% CI 18.5–26.7%) of the LE of the background population. (LE for 20-year-olds in the background population was 44.0 years [95% CI 43.0–44.9].) Patients diagnosed with CD4 cell counts below 200 cells/µL had a LE of 5.7 years (95% CI 3.6–8.2). No increase in LE with later calendar period of diagnosis was observed. Conclusions: LE was shown to be markedly lower among HIV-infected patients compared with the background population. While other settings have shown marked improvements in prognosis of HIV-infected patients in recent years, no improvement in Bissau was observed over time (9.8 years (95% CI 7.6–12.2) and 9.9 years (95% CI 7.6–12.1) for the periods 2005–2010 and 2014–2016, respectively).

Udgave nummer4
Sider (fra-til)631-643
StatusUdgivet - aug. 2021

Bibliografisk note

Funding Information:
No specific funding support was received for this study. The HIV clinic at HNSM is supported by The Global Fund through the National HIV Programme in Guinea-Bissau. The primary investigator received a scholarship from Aarhus University, Denmark. Thomas Engell-Sørensen was supported by Aarhus University Research Foundation (project no. 22335). Andreas Rieckmann was supported by the Danish National Research Foundation (Grant no. DNRF108) to Research Center for Vitamins and Vaccines (CVIVA) and by an unrestricted Faculty of Health Sciences scholarship from the University of Southern Denmark. The Bandim Health Project received support from the Danish National Research Foundation via Research Center for Vitamins and Vaccines [DNRF108], and the most recent census was funded by a grant from DANIDA and the Novo Nordisk Foundation. None of the funding sources were involved in the design, data collection, analysis or writing of the study.

Publisher Copyright:
© 2021, Springer-Verlag GmbH, DE part of Springer Nature.

Copyright 2021 Elsevier B.V., All rights reserved.


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