Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5

Morten Frost Nielsen, Tom E. Andersen, F Gossiel, S Hansen, J Bollerslev, W Van Hul, R Eastell, M Kassem, K Brixen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

CONTEXT: Patients with an activation mutation of the Lrp5 gene exhibit high bone mass (HBM). Limited information is available regarding compartment specific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. Objective: to evaluate bone, serotonin and bone turnover markers (BTM) in Lrp5-HBM patients. DESIGN: We studied 19 Lrp5-HBM patients (T253I) and 19 age- and sex-matched controls. DXA and HR-pQCT were used to assess BMD and bone structure. Serum serotonin, sclerostin, DKK1 and BTM were evaluated. RESULTS: Z-scores for the forearm, total hip, lumbar spine, forearm and whole body were significantly increased (mean ± SD) between 4.94 ± 1.45 and 7.52 ± 1.99 in cases as compared to -0.19 ± 1.19 to 0.58 ± 0.84 in controls. Tibial and radial cortical areas, thicknesses and BMD were significantly higher in cases. In cases, BMD at the lumbar spine and forearm and cortical thickness were positively and trabecular area negatively associated with age (r =0.49, 0.57, 0.74 and -0.61, respectively, p 
OriginalsprogEngelsk
TidsskriftJournal of Bone and Mineral Research
Vol/bind26
Udgave nummer8
Sider (fra-til)1721-1728
Antal sider8
ISSN0884-0431
DOI
StatusUdgivet - 2011

Fingeraftryk

Bone Density
Mutation
Forearm
Serum
Hip

Citer dette

@article{48ea742a96604d75a705f17b2618310d,
title = "Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5",
abstract = "CONTEXT: Patients with an activation mutation of the Lrp5 gene exhibit high bone mass (HBM). Limited information is available regarding compartment specific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. Objective: to evaluate bone, serotonin and bone turnover markers (BTM) in Lrp5-HBM patients. DESIGN: We studied 19 Lrp5-HBM patients (T253I) and 19 age- and sex-matched controls. DXA and HR-pQCT were used to assess BMD and bone structure. Serum serotonin, sclerostin, DKK1 and BTM were evaluated. RESULTS: Z-scores for the forearm, total hip, lumbar spine, forearm and whole body were significantly increased (mean ± SD) between 4.94 ± 1.45 and 7.52 ± 1.99 in cases as compared to -0.19 ± 1.19 to 0.58 ± 0.84 in controls. Tibial and radial cortical areas, thicknesses and BMD were significantly higher in cases. In cases, BMD at the lumbar spine and forearm and cortical thickness were positively and trabecular area negatively associated with age (r =0.49, 0.57, 0.74 and -0.61, respectively, p ",
author = "Nielsen, {Morten Frost} and Andersen, {Tom E.} and F Gossiel and S Hansen and J Bollerslev and {Van Hul}, W and R Eastell and M Kassem and K Brixen",
note = "Copyright {\circledC} 2011 American Society for Bone and Mineral Research.",
year = "2011",
doi = "10.1002/jbmr.376",
language = "English",
volume = "26",
pages = "1721--1728",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
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}

Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5. / Nielsen, Morten Frost; Andersen, Tom E.; Gossiel, F; Hansen, S; Bollerslev, J; Van Hul, W; Eastell, R; Kassem, M; Brixen, K.

I: Journal of Bone and Mineral Research, Bind 26, Nr. 8, 2011, s. 1721-1728.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5

AU - Nielsen, Morten Frost

AU - Andersen, Tom E.

AU - Gossiel, F

AU - Hansen, S

AU - Bollerslev, J

AU - Van Hul, W

AU - Eastell, R

AU - Kassem, M

AU - Brixen, K

N1 - Copyright © 2011 American Society for Bone and Mineral Research.

PY - 2011

Y1 - 2011

N2 - CONTEXT: Patients with an activation mutation of the Lrp5 gene exhibit high bone mass (HBM). Limited information is available regarding compartment specific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. Objective: to evaluate bone, serotonin and bone turnover markers (BTM) in Lrp5-HBM patients. DESIGN: We studied 19 Lrp5-HBM patients (T253I) and 19 age- and sex-matched controls. DXA and HR-pQCT were used to assess BMD and bone structure. Serum serotonin, sclerostin, DKK1 and BTM were evaluated. RESULTS: Z-scores for the forearm, total hip, lumbar spine, forearm and whole body were significantly increased (mean ± SD) between 4.94 ± 1.45 and 7.52 ± 1.99 in cases as compared to -0.19 ± 1.19 to 0.58 ± 0.84 in controls. Tibial and radial cortical areas, thicknesses and BMD were significantly higher in cases. In cases, BMD at the lumbar spine and forearm and cortical thickness were positively and trabecular area negatively associated with age (r =0.49, 0.57, 0.74 and -0.61, respectively, p 

AB - CONTEXT: Patients with an activation mutation of the Lrp5 gene exhibit high bone mass (HBM). Limited information is available regarding compartment specific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. Objective: to evaluate bone, serotonin and bone turnover markers (BTM) in Lrp5-HBM patients. DESIGN: We studied 19 Lrp5-HBM patients (T253I) and 19 age- and sex-matched controls. DXA and HR-pQCT were used to assess BMD and bone structure. Serum serotonin, sclerostin, DKK1 and BTM were evaluated. RESULTS: Z-scores for the forearm, total hip, lumbar spine, forearm and whole body were significantly increased (mean ± SD) between 4.94 ± 1.45 and 7.52 ± 1.99 in cases as compared to -0.19 ± 1.19 to 0.58 ± 0.84 in controls. Tibial and radial cortical areas, thicknesses and BMD were significantly higher in cases. In cases, BMD at the lumbar spine and forearm and cortical thickness were positively and trabecular area negatively associated with age (r =0.49, 0.57, 0.74 and -0.61, respectively, p 

U2 - 10.1002/jbmr.376

DO - 10.1002/jbmr.376

M3 - Journal article

C2 - 21351148

VL - 26

SP - 1721

EP - 1728

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 8

ER -