Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections

Nina Breinholt Stærke, Joanne Reekie, Henrik Nielsen, Thomas Benfield, Lothar Wiese, Lene Surland Knudsen, Mette Brouw Iversen, Kasper Iversen, Kamille Fogh, Jacob Bodilsen, Maria Ruwald Juhl, Susan Olaf Lindvig, Anne Øvrehus, Lone Wulff Madsen, Vibeke Klastrup, Sidsel Dahl Andersen, Anna Karina Juhl, Signe Rode Andreasen, Sisse Rye Ostrowski, Christian ErikstrupThea K Fischer, Martin Tolstrup, Lars Østergaard, Isik Somuncu Johansen, Jens Lundgren, Ole Schmeltz Søgaard

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Abstrakt

SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of breakthrough infection in a fully vaccinated cohort. SARS-CoV-2 anti-spike IgG levels were measured before first SARS-CoV-2 vaccination and at day 21-28, 90 and 180, as well as after booster vaccination. Breakthrough infections were captured through the Danish National Microbiology database. incidence rate ratio (IRR) for breakthrough infection at time-updated anti-spike IgG levels was determined using Poisson regression. Among 6076 participants, 127 and 364 breakthrough infections due to Delta and Omicron variants were observed. IRR was 0.29 (95% CI 0.15-0.56) for breakthrough infection with the Delta variant, comparing the highest and lowest quintiles of anti-spike IgG. For Omicron, no significant differences in IRR were observed. These results suggest that quantitative level of anti-spike IgG have limited impact on the risk of breakthrough infection with Omicron.

OriginalsprogEngelsk
Artikelnummer4466
TidsskriftNature Communications
Vol/bind13
Antal sider8
ISSN2041-1723
DOI
StatusUdgivet - 1. aug. 2022

Bibliografisk note

Funding Information:
We thank the ENFORCE study group for their continued commitment to this study. A list of study group members is provided as . This study was fully funded by the Danish Ministry of Health (act 150, January 28th 2021, LØ).

Publisher Copyright:
© 2022, The Author(s).

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