Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice

N Barascuk, E Vassiliadis, Qiuju Zheng, Yu Wang, W Wang, L Larsen, L M Rasmussen, M A Karsdal

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Arterial extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) is one of the major hallmarks of atherosclerosis. Mimecan, also known as osteoglycin has been implicated in the integrity of the ECM. This study assessed the validity of an enzyme-linked immunosorbent assay (ELISA) developed to measure a specific MMP12-derived fragment of mimecan, MMCN-151, in apolipoprotein-E knockout (ApoE-KO) mice.
OriginalsprogEngelsk
TidsskriftBiomarker Insights
Vol/bind6
Sider (fra-til)97-106
Antal sider10
ISSN1177-2719
DOI
StatusUdgivet - 2011

Fingeraftryk

Immunosorbents
Apolipoproteins E
Matrix Metalloproteinases
Assays
Degradation
Enzymes

Citer dette

@article{1e39781c66014f76a3738e59c7d9e4cb,
title = "Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice",
abstract = "Arterial extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) is one of the major hallmarks of atherosclerosis. Mimecan, also known as osteoglycin has been implicated in the integrity of the ECM. This study assessed the validity of an enzyme-linked immunosorbent assay (ELISA) developed to measure a specific MMP12-derived fragment of mimecan, MMCN-151, in apolipoprotein-E knockout (ApoE-KO) mice.",
author = "N Barascuk and E Vassiliadis and Qiuju Zheng and Yu Wang and W Wang and L Larsen and Rasmussen, {L M} and Karsdal, {M A}",
year = "2011",
doi = "10.4137/BMI.S7777",
language = "English",
volume = "6",
pages = "97--106",
journal = "Biomarker Insights",
issn = "1177-2719",
publisher = "Libertas Academica Ltd.",

}

Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice. / Barascuk, N; Vassiliadis, E; Zheng, Qiuju; Wang, Yu; Wang, W; Larsen, L; Rasmussen, L M; Karsdal, M A.

I: Biomarker Insights, Bind 6, 2011, s. 97-106.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice

AU - Barascuk, N

AU - Vassiliadis, E

AU - Zheng, Qiuju

AU - Wang, Yu

AU - Wang, W

AU - Larsen, L

AU - Rasmussen, L M

AU - Karsdal, M A

PY - 2011

Y1 - 2011

N2 - Arterial extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) is one of the major hallmarks of atherosclerosis. Mimecan, also known as osteoglycin has been implicated in the integrity of the ECM. This study assessed the validity of an enzyme-linked immunosorbent assay (ELISA) developed to measure a specific MMP12-derived fragment of mimecan, MMCN-151, in apolipoprotein-E knockout (ApoE-KO) mice.

AB - Arterial extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) is one of the major hallmarks of atherosclerosis. Mimecan, also known as osteoglycin has been implicated in the integrity of the ECM. This study assessed the validity of an enzyme-linked immunosorbent assay (ELISA) developed to measure a specific MMP12-derived fragment of mimecan, MMCN-151, in apolipoprotein-E knockout (ApoE-KO) mice.

U2 - 10.4137/BMI.S7777

DO - 10.4137/BMI.S7777

M3 - Journal article

VL - 6

SP - 97

EP - 106

JO - Biomarker Insights

JF - Biomarker Insights

SN - 1177-2719

ER -