Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

Peter M Christensen, Michael Nyberg, Stefan Mortensen, Jens Jung Nielsen, Niels H. Secher, Rasmus Damsgaard, Ylva Hellsten, Jens Bangsbo

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Abstrakt

The present study examined whether a marked reduction in oxygen delivery, unlike findings in moderate-intensity exercise, would slow leg oxygen uptake (Vo2) kinetics during intense exercise (86 ± 3% of incremental test peak power). Seven healthy males (26 ± 1 years, means ± SE) performed one-legged knee-extensor exercise (60 ± 3 W) for 4 min in a control setting (CON) and with arterial infusion of N(G)-monomethyl-l-arginine and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P
OriginalsprogEngelsk
TidsskriftA J P: Regulatory, Integrative and Comparative Physiology (Online)
Vol/bind305
Udgave nummer3
Sider (fra-til)R313-21
ISSN1522-1490
DOI
StatusUdgivet - 1. aug. 2013
Udgivet eksterntJa

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