Left ventricular performance during triggered left ventricular pacing in patients with cardiac resynchronization therapy and left bundle branch block

Christoffer Tobias Witt, Mads Brix Kronborg, Ellen Aagaard Nohr, Jens Cosedis Nielsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

PURPOSE: To assess the acute effect of triggered left ventricular pacing (tLVp) on left ventricular performance and contraction pattern in patients with heart failure, left bundle branch block (LBBB), and cardiac resynchronization therapy (CRT).

METHODS: Twenty-three patients with pre-implant QRS complex >150 ms, QRS complex narrowing under CRT, and sinus rhythm were included ≥3 months after CRT implantation. Echocardiographic assessment of left ventricular ejection fraction (LVEF), global peak systolic longitudinal strain (GLS), and contraction pattern by 2D strain was performed during intrinsic conduction, tLVp, and BiV pacing and compared as paired data. Echocardiographic analysis was done blinded with respect to pacing mode.

RESULTS: LVEF was significantly higher during BiV pacing (47 ± 11 %) compared with intrinsic conduction (43 ± 13 %, P = 0.001) and tLVp (44 ± 13 %, P = 0.001), while there was no difference between intrinsic conduction and tLVp (P = 0.28). GLS was higher during BiV (14 ± 3) than during intrinsic conduction (13 ± 3, P = 0.01) and tLVp (13 ± 3, P = 0.03). Difference in time-to-peak contraction between the basal septal and lateral walls was shorter during BiV pacing (-3 ± 44 ms) than during intrinsic conduction (129 ± 66, P < 0.001) and tLVp (118 ± 118 ms, P < 0.001), with no difference between tLVp and intrinsic conduction (P = 0.56). The electrocardiogram showed change in frontal axis from intrinsic conduction in only 2 (9 %) patients during tLVp and in 20 (87 %) patients during BiV pacing.

CONCLUSIONS: The acute effect of tLVp on LV systolic function and contraction pattern is significantly lower than the effect of BiV pacing and not different from intrinsic conduction in patients with LBBB and CRT.

OriginalsprogEngelsk
TidsskriftJournal of Interventional Cardiac Electrophysiology
Vol/bind46
Udgave nummer3
Sider (fra-til)345-351
ISSN1383-875X
DOI
StatusUdgivet - sep. 2016

Fingeraftryk

Cardiac Resynchronization Therapy
Electrocardiography

Citer dette

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title = "Left ventricular performance during triggered left ventricular pacing in patients with cardiac resynchronization therapy and left bundle branch block",
abstract = "PURPOSE: To assess the acute effect of triggered left ventricular pacing (tLVp) on left ventricular performance and contraction pattern in patients with heart failure, left bundle branch block (LBBB), and cardiac resynchronization therapy (CRT).METHODS: Twenty-three patients with pre-implant QRS complex >150 ms, QRS complex narrowing under CRT, and sinus rhythm were included ≥3 months after CRT implantation. Echocardiographic assessment of left ventricular ejection fraction (LVEF), global peak systolic longitudinal strain (GLS), and contraction pattern by 2D strain was performed during intrinsic conduction, tLVp, and BiV pacing and compared as paired data. Echocardiographic analysis was done blinded with respect to pacing mode.RESULTS: LVEF was significantly higher during BiV pacing (47 ± 11 {\%}) compared with intrinsic conduction (43 ± 13 {\%}, P = 0.001) and tLVp (44 ± 13 {\%}, P = 0.001), while there was no difference between intrinsic conduction and tLVp (P = 0.28). GLS was higher during BiV (14 ± 3) than during intrinsic conduction (13 ± 3, P = 0.01) and tLVp (13 ± 3, P = 0.03). Difference in time-to-peak contraction between the basal septal and lateral walls was shorter during BiV pacing (-3 ± 44 ms) than during intrinsic conduction (129 ± 66, P < 0.001) and tLVp (118 ± 118 ms, P < 0.001), with no difference between tLVp and intrinsic conduction (P = 0.56). The electrocardiogram showed change in frontal axis from intrinsic conduction in only 2 (9 {\%}) patients during tLVp and in 20 (87 {\%}) patients during BiV pacing.CONCLUSIONS: The acute effect of tLVp on LV systolic function and contraction pattern is significantly lower than the effect of BiV pacing and not different from intrinsic conduction in patients with LBBB and CRT.",
keywords = "Journal Article",
author = "Witt, {Christoffer Tobias} and Kronborg, {Mads Brix} and Nohr, {Ellen Aagaard} and Nielsen, {Jens Cosedis}",
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Left ventricular performance during triggered left ventricular pacing in patients with cardiac resynchronization therapy and left bundle branch block. / Witt, Christoffer Tobias; Kronborg, Mads Brix; Nohr, Ellen Aagaard; Nielsen, Jens Cosedis.

I: Journal of Interventional Cardiac Electrophysiology, Bind 46, Nr. 3, 09.2016, s. 345-351.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Left ventricular performance during triggered left ventricular pacing in patients with cardiac resynchronization therapy and left bundle branch block

AU - Witt, Christoffer Tobias

AU - Kronborg, Mads Brix

AU - Nohr, Ellen Aagaard

AU - Nielsen, Jens Cosedis

PY - 2016/9

Y1 - 2016/9

N2 - PURPOSE: To assess the acute effect of triggered left ventricular pacing (tLVp) on left ventricular performance and contraction pattern in patients with heart failure, left bundle branch block (LBBB), and cardiac resynchronization therapy (CRT).METHODS: Twenty-three patients with pre-implant QRS complex >150 ms, QRS complex narrowing under CRT, and sinus rhythm were included ≥3 months after CRT implantation. Echocardiographic assessment of left ventricular ejection fraction (LVEF), global peak systolic longitudinal strain (GLS), and contraction pattern by 2D strain was performed during intrinsic conduction, tLVp, and BiV pacing and compared as paired data. Echocardiographic analysis was done blinded with respect to pacing mode.RESULTS: LVEF was significantly higher during BiV pacing (47 ± 11 %) compared with intrinsic conduction (43 ± 13 %, P = 0.001) and tLVp (44 ± 13 %, P = 0.001), while there was no difference between intrinsic conduction and tLVp (P = 0.28). GLS was higher during BiV (14 ± 3) than during intrinsic conduction (13 ± 3, P = 0.01) and tLVp (13 ± 3, P = 0.03). Difference in time-to-peak contraction between the basal septal and lateral walls was shorter during BiV pacing (-3 ± 44 ms) than during intrinsic conduction (129 ± 66, P < 0.001) and tLVp (118 ± 118 ms, P < 0.001), with no difference between tLVp and intrinsic conduction (P = 0.56). The electrocardiogram showed change in frontal axis from intrinsic conduction in only 2 (9 %) patients during tLVp and in 20 (87 %) patients during BiV pacing.CONCLUSIONS: The acute effect of tLVp on LV systolic function and contraction pattern is significantly lower than the effect of BiV pacing and not different from intrinsic conduction in patients with LBBB and CRT.

AB - PURPOSE: To assess the acute effect of triggered left ventricular pacing (tLVp) on left ventricular performance and contraction pattern in patients with heart failure, left bundle branch block (LBBB), and cardiac resynchronization therapy (CRT).METHODS: Twenty-three patients with pre-implant QRS complex >150 ms, QRS complex narrowing under CRT, and sinus rhythm were included ≥3 months after CRT implantation. Echocardiographic assessment of left ventricular ejection fraction (LVEF), global peak systolic longitudinal strain (GLS), and contraction pattern by 2D strain was performed during intrinsic conduction, tLVp, and BiV pacing and compared as paired data. Echocardiographic analysis was done blinded with respect to pacing mode.RESULTS: LVEF was significantly higher during BiV pacing (47 ± 11 %) compared with intrinsic conduction (43 ± 13 %, P = 0.001) and tLVp (44 ± 13 %, P = 0.001), while there was no difference between intrinsic conduction and tLVp (P = 0.28). GLS was higher during BiV (14 ± 3) than during intrinsic conduction (13 ± 3, P = 0.01) and tLVp (13 ± 3, P = 0.03). Difference in time-to-peak contraction between the basal septal and lateral walls was shorter during BiV pacing (-3 ± 44 ms) than during intrinsic conduction (129 ± 66, P < 0.001) and tLVp (118 ± 118 ms, P < 0.001), with no difference between tLVp and intrinsic conduction (P = 0.56). The electrocardiogram showed change in frontal axis from intrinsic conduction in only 2 (9 %) patients during tLVp and in 20 (87 %) patients during BiV pacing.CONCLUSIONS: The acute effect of tLVp on LV systolic function and contraction pattern is significantly lower than the effect of BiV pacing and not different from intrinsic conduction in patients with LBBB and CRT.

KW - Journal Article

U2 - 10.1007/s10840-016-0155-0

DO - 10.1007/s10840-016-0155-0

M3 - Journal article

C2 - 27272650

VL - 46

SP - 345

EP - 351

JO - Journal of Interventional Cardiac Electrophysiology

JF - Journal of Interventional Cardiac Electrophysiology

SN - 1383-875X

IS - 3

ER -