TY - JOUR
T1 - Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus: Prevalence and Association with Myocardial and Vascular Disease
AU - Poulsen, Mikael Kjaer
AU - Henriksen, Jan Erik
AU - Dahl, Jordi
AU - Johansen, Allan
AU - Gerke, Oke
AU - Vach, Werner
AU - Haghfelt, Torben
AU - Høilund-Carlsen, Poul Fl.
AU - Beck-Nielsen, Henning
AU - Møller, Jacob Eifer
PY - 2010
Y1 - 2010
N2 - BACKGROUND: -Although, type 2 diabetes mellitus (T2DM) is a risk factor for developing congestive heart failure the mechanism leading to heart failure is unclear. We examined the prevalence of left ventricular (LV) systolic and diastolic dysfunction in T2DM patients in relation to vascular function and myocardial perfusion. METHODS AND RESULTS: -In a prospective observational study 305 T2DM patients (diabetes duration: 4.5+/-5.3 years) referred consecutively to a diabetes clinic for the first time were screened for LV systolic and diastolic function by echocardiography. Vascular function was estimated using noninvasive estimation of pulse pressure, carotid arterial compliance, total arterial compliance, and valvulo-arterial impedance. The prevalences of LV diastolic dysfunction and left atrial volume index (LAVI) >32 ml/m(2) were 40% and 32%, respectively. The prevalence of myocardial ischemia on myocardial perfusion scintigraphy (MPS) was more frequent in patients with grade 2 diastolic dysfunction and LAVI >32 ml/m(2) compared with those having normal or grade 1 diastolic dysfunction (p=0.002) or LAVI
AB - BACKGROUND: -Although, type 2 diabetes mellitus (T2DM) is a risk factor for developing congestive heart failure the mechanism leading to heart failure is unclear. We examined the prevalence of left ventricular (LV) systolic and diastolic dysfunction in T2DM patients in relation to vascular function and myocardial perfusion. METHODS AND RESULTS: -In a prospective observational study 305 T2DM patients (diabetes duration: 4.5+/-5.3 years) referred consecutively to a diabetes clinic for the first time were screened for LV systolic and diastolic function by echocardiography. Vascular function was estimated using noninvasive estimation of pulse pressure, carotid arterial compliance, total arterial compliance, and valvulo-arterial impedance. The prevalences of LV diastolic dysfunction and left atrial volume index (LAVI) >32 ml/m(2) were 40% and 32%, respectively. The prevalence of myocardial ischemia on myocardial perfusion scintigraphy (MPS) was more frequent in patients with grade 2 diastolic dysfunction and LAVI >32 ml/m(2) compared with those having normal or grade 1 diastolic dysfunction (p=0.002) or LAVI
U2 - 10.1161/CIRCIMAGING.109.855510
DO - 10.1161/CIRCIMAGING.109.855510
M3 - Journal article
C2 - 19846730
SN - 1941-9651
VL - 3
SP - 24
EP - 31
JO - Circulation. Cardiovascular Imaging
JF - Circulation. Cardiovascular Imaging
ER -