Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

Kristoffer Sølvsten Burgdorf*, Betina B. Trabjerg, Marianne Giørtz Pedersen, Janna Nissen, Karina Banasik, Ole Birger Pedersen, Erik Sørensen, Kaspar René Nielsen, Margit Hørup Larsen, Christian Erikstrup, Peter Bruun-Rasmussen, David Westergaard, Lise Wegner Thørner, Henrik Hjalgrim, Helene Martina Paarup, Søren Brunak, Carsten B. Pedersen, E. Fuller Torrey, Thomas Werge, Preben Bo Mortensen & 2 andre Robert H. Yolken, Henrik Ullum

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

50 Downloads (Pure)

Resumé

Background: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. Methods: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV). Results: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03–2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27–6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00–1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06–1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12–1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10–1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08–1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01–2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97–1·17) was found. Conclusions: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

OriginalsprogEngelsk
TidsskriftBrain, Behavior, and Immunity
Vol/bind79
Sider (fra-til)152-158
ISSN0889-1591
DOI
StatusUdgivet - jul. 2019

Fingeraftryk

Cytomegalovirus
Confidence Intervals
Odds Ratio
Traffic Accidents
Risk-Taking
Population
Case-Control Studies

Citer dette

Burgdorf, K. S., Trabjerg, B. B., Pedersen, M. G., Nissen, J., Banasik, K., Pedersen, O. B., ... Ullum, H. (2019). Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain, Behavior, and Immunity, 79, 152-158. https://doi.org/10.1016/j.bbi.2019.01.026
Burgdorf, Kristoffer Sølvsten ; Trabjerg, Betina B. ; Pedersen, Marianne Giørtz ; Nissen, Janna ; Banasik, Karina ; Pedersen, Ole Birger ; Sørensen, Erik ; Nielsen, Kaspar René ; Larsen, Margit Hørup ; Erikstrup, Christian ; Bruun-Rasmussen, Peter ; Westergaard, David ; Thørner, Lise Wegner ; Hjalgrim, Henrik ; Paarup, Helene Martina ; Brunak, Søren ; Pedersen, Carsten B. ; Torrey, E. Fuller ; Werge, Thomas ; Mortensen, Preben Bo ; Yolken, Robert H. ; Ullum, Henrik. / Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. I: Brain, Behavior, and Immunity. 2019 ; Bind 79. s. 152-158.
@article{c0cd9c52552b4e25b09d6736b98d6c75,
title = "Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders",
abstract = "Background: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. Methods: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV). Results: T. gondii was detected in 25·9{\%} of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95{\%} confidence interval [CI], 1·03–2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95{\%} CI, 1·27–6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95{\%} CI, 1·00–1·23, p = 0.054) was found. CMV was detected in 60·8{\%} of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95{\%} CI, 1·06–1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95{\%} CI, 1·12–1·44), and with attempting or committing suicide (OR, 1·31; 95{\%} CI, 1·10–1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95{\%} CI, 1·08–1·74) and mood disorders (IRR, 1·43; 95{\%} CI, 1·01–2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95{\%} CI, 0·97–1·17) was found. Conclusions: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.",
keywords = "Antibodies, Cytomegalovirus, Infection, Parasite, psychiatric disorders, Serology, Suicide, Toxoplasma gondii, Toxoplasmosis, Traffic accidents",
author = "Burgdorf, {Kristoffer S{\o}lvsten} and Trabjerg, {Betina B.} and Pedersen, {Marianne Gi{\o}rtz} and Janna Nissen and Karina Banasik and Pedersen, {Ole Birger} and Erik S{\o}rensen and Nielsen, {Kaspar Ren{\'e}} and Larsen, {Margit H{\o}rup} and Christian Erikstrup and Peter Bruun-Rasmussen and David Westergaard and Th{\o}rner, {Lise Wegner} and Henrik Hjalgrim and Paarup, {Helene Martina} and S{\o}ren Brunak and Pedersen, {Carsten B.} and Torrey, {E. Fuller} and Thomas Werge and Mortensen, {Preben Bo} and Yolken, {Robert H.} and Henrik Ullum",
year = "2019",
month = "7",
doi = "10.1016/j.bbi.2019.01.026",
language = "English",
volume = "79",
pages = "152--158",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Heinemann",

}

Burgdorf, KS, Trabjerg, BB, Pedersen, MG, Nissen, J, Banasik, K, Pedersen, OB, Sørensen, E, Nielsen, KR, Larsen, MH, Erikstrup, C, Bruun-Rasmussen, P, Westergaard, D, Thørner, LW, Hjalgrim, H, Paarup, HM, Brunak, S, Pedersen, CB, Torrey, EF, Werge, T, Mortensen, PB, Yolken, RH & Ullum, H 2019, 'Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders', Brain, Behavior, and Immunity, bind 79, s. 152-158. https://doi.org/10.1016/j.bbi.2019.01.026

Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. / Burgdorf, Kristoffer Sølvsten; Trabjerg, Betina B.; Pedersen, Marianne Giørtz; Nissen, Janna; Banasik, Karina; Pedersen, Ole Birger; Sørensen, Erik; Nielsen, Kaspar René; Larsen, Margit Hørup; Erikstrup, Christian; Bruun-Rasmussen, Peter; Westergaard, David; Thørner, Lise Wegner; Hjalgrim, Henrik; Paarup, Helene Martina; Brunak, Søren; Pedersen, Carsten B.; Torrey, E. Fuller; Werge, Thomas; Mortensen, Preben Bo; Yolken, Robert H.; Ullum, Henrik.

I: Brain, Behavior, and Immunity, Bind 79, 07.2019, s. 152-158.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

AU - Burgdorf, Kristoffer Sølvsten

AU - Trabjerg, Betina B.

AU - Pedersen, Marianne Giørtz

AU - Nissen, Janna

AU - Banasik, Karina

AU - Pedersen, Ole Birger

AU - Sørensen, Erik

AU - Nielsen, Kaspar René

AU - Larsen, Margit Hørup

AU - Erikstrup, Christian

AU - Bruun-Rasmussen, Peter

AU - Westergaard, David

AU - Thørner, Lise Wegner

AU - Hjalgrim, Henrik

AU - Paarup, Helene Martina

AU - Brunak, Søren

AU - Pedersen, Carsten B.

AU - Torrey, E. Fuller

AU - Werge, Thomas

AU - Mortensen, Preben Bo

AU - Yolken, Robert H.

AU - Ullum, Henrik

PY - 2019/7

Y1 - 2019/7

N2 - Background: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. Methods: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV). Results: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03–2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27–6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00–1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06–1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12–1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10–1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08–1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01–2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97–1·17) was found. Conclusions: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

AB - Background: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. Methods: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV). Results: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03–2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27–6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00–1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06–1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12–1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10–1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08–1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01–2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97–1·17) was found. Conclusions: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

KW - Antibodies

KW - Cytomegalovirus

KW - Infection

KW - Parasite, psychiatric disorders

KW - Serology

KW - Suicide

KW - Toxoplasma gondii

KW - Toxoplasmosis

KW - Traffic accidents

U2 - 10.1016/j.bbi.2019.01.026

DO - 10.1016/j.bbi.2019.01.026

M3 - Journal article

VL - 79

SP - 152

EP - 158

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

ER -