Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis

Erik Poulsen, Glaucia H Goncalves, Alessio Bricca, Ewa M Roos, Jonas B Thorlund, Carsten B Juhl

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective To estimate knee osteoarthritis (OA) risk following anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury. Design Systematic review and meta-analysis. Data sources MEDLINE, Embase, SPORTDiscus, CINAHL and Web of Science until November 2018. Eligibility criteria for selecting studies Prospective or retrospective studies with at least 2-year follow-up including adults with ACL injury, meniscal injury or combined injuries. Knee OA was defined by radiographs or clinical diagnosis and compared with the contralateral knee or non-injured controls. Study appraisal and synthesis Risk of bias was assessed using the SIGN50 checklist. ORs for developing knee OA were estimated using random effects meta-analysis. Results 53 studies totalling â 1/41 million participants were included: 185 219 participants with ACL injury, mean age 28 years, 35% females, 98% surgically reconstructed; 83 267 participants with meniscal injury, mean age 38 years, 36% females, 22% confirmed meniscectomy and 73% unknown; 725 362 participants with combined injury, mean age 31 years, 26% females, 80% treated surgically. The OR of developing knee OA were 4.2 (95% CI 2.2 to 8.0; I 2 =92%), 6.3 (95% CI 3.8 to 10.5; I 2 =95%) and 6.4 (95% CI 4.9 to 8.3; I 2 =62%) for patients with ACL injury, meniscal injury and combined injuries, respectively. Conclusion The odds of developing knee OA following ACL injury are approximately four times higher compared with a non-injured knee. A meniscal injury and a combined injury affecting both the ACL and meniscus are associated with six times higher odds compared with a non-injured knee. Large inconsistency (eg, study design, follow-up period and comparator) and few high-quality studies suggest that future studies may change these estimates. Clinical relevance Patients sustaining a major knee injury have a substantially increased risk of developing knee OA, highlighting the importance of knee injury prevention programmes and secondary prevention strategies to prevent or delay knee OA development. PROSPERO registration number CRD42015016900.

OriginalsprogEngelsk
TidsskriftBritish Journal of Sports Medicine
Vol/bind53
Udgave nummer23
Sider (fra-til)1454-1463
ISSN0306-3674
DOI
StatusUdgivet - 1. dec. 2019

Fingeraftryk

Knee Injuries
Knee Osteoarthritis
Meta-Analysis
Wounds and Injuries
Knee
Anterior Cruciate Ligament
Information Storage and Retrieval
Checklist
MEDLINE
Retrospective Studies
Prospective Studies

Bibliografisk note

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Citer dette

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title = "Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis",
abstract = "Objective To estimate knee osteoarthritis (OA) risk following anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury. Design Systematic review and meta-analysis. Data sources MEDLINE, Embase, SPORTDiscus, CINAHL and Web of Science until November 2018. Eligibility criteria for selecting studies Prospective or retrospective studies with at least 2-year follow-up including adults with ACL injury, meniscal injury or combined injuries. Knee OA was defined by radiographs or clinical diagnosis and compared with the contralateral knee or non-injured controls. Study appraisal and synthesis Risk of bias was assessed using the SIGN50 checklist. ORs for developing knee OA were estimated using random effects meta-analysis. Results 53 studies totalling {\^a} 1/41 million participants were included: 185 219 participants with ACL injury, mean age 28 years, 35{\%} females, 98{\%} surgically reconstructed; 83 267 participants with meniscal injury, mean age 38 years, 36{\%} females, 22{\%} confirmed meniscectomy and 73{\%} unknown; 725 362 participants with combined injury, mean age 31 years, 26{\%} females, 80{\%} treated surgically. The OR of developing knee OA were 4.2 (95{\%} CI 2.2 to 8.0; I 2 =92{\%}), 6.3 (95{\%} CI 3.8 to 10.5; I 2 =95{\%}) and 6.4 (95{\%} CI 4.9 to 8.3; I 2 =62{\%}) for patients with ACL injury, meniscal injury and combined injuries, respectively. Conclusion The odds of developing knee OA following ACL injury are approximately four times higher compared with a non-injured knee. A meniscal injury and a combined injury affecting both the ACL and meniscus are associated with six times higher odds compared with a non-injured knee. Large inconsistency (eg, study design, follow-up period and comparator) and few high-quality studies suggest that future studies may change these estimates. Clinical relevance Patients sustaining a major knee injury have a substantially increased risk of developing knee OA, highlighting the importance of knee injury prevention programmes and secondary prevention strategies to prevent or delay knee OA development. PROSPERO registration number CRD42015016900.",
keywords = "Anterior Cruciate Ligament Injuries/complications, Humans, Knee Injuries/complications, Osteoarthritis, Knee/etiology, Risk Factors, Tibial Meniscus Injuries/complications",
author = "Erik Poulsen and Goncalves, {Glaucia H} and Alessio Bricca and Roos, {Ewa M} and Thorlund, {Jonas B} and Juhl, {Carsten B}",
note = "{\circledC} Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = "12",
day = "1",
doi = "10.1136/bjsports-2018-100022",
language = "English",
volume = "53",
pages = "1454--1463",
journal = "British Journal of Sports Medicine",
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Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis. / Poulsen, Erik; Goncalves, Glaucia H; Bricca, Alessio; Roos, Ewa M; Thorlund, Jonas B; Juhl, Carsten B.

I: British Journal of Sports Medicine, Bind 53, Nr. 23, 01.12.2019, s. 1454-1463.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis

AU - Poulsen, Erik

AU - Goncalves, Glaucia H

AU - Bricca, Alessio

AU - Roos, Ewa M

AU - Thorlund, Jonas B

AU - Juhl, Carsten B

N1 - © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Objective To estimate knee osteoarthritis (OA) risk following anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury. Design Systematic review and meta-analysis. Data sources MEDLINE, Embase, SPORTDiscus, CINAHL and Web of Science until November 2018. Eligibility criteria for selecting studies Prospective or retrospective studies with at least 2-year follow-up including adults with ACL injury, meniscal injury or combined injuries. Knee OA was defined by radiographs or clinical diagnosis and compared with the contralateral knee or non-injured controls. Study appraisal and synthesis Risk of bias was assessed using the SIGN50 checklist. ORs for developing knee OA were estimated using random effects meta-analysis. Results 53 studies totalling â 1/41 million participants were included: 185 219 participants with ACL injury, mean age 28 years, 35% females, 98% surgically reconstructed; 83 267 participants with meniscal injury, mean age 38 years, 36% females, 22% confirmed meniscectomy and 73% unknown; 725 362 participants with combined injury, mean age 31 years, 26% females, 80% treated surgically. The OR of developing knee OA were 4.2 (95% CI 2.2 to 8.0; I 2 =92%), 6.3 (95% CI 3.8 to 10.5; I 2 =95%) and 6.4 (95% CI 4.9 to 8.3; I 2 =62%) for patients with ACL injury, meniscal injury and combined injuries, respectively. Conclusion The odds of developing knee OA following ACL injury are approximately four times higher compared with a non-injured knee. A meniscal injury and a combined injury affecting both the ACL and meniscus are associated with six times higher odds compared with a non-injured knee. Large inconsistency (eg, study design, follow-up period and comparator) and few high-quality studies suggest that future studies may change these estimates. Clinical relevance Patients sustaining a major knee injury have a substantially increased risk of developing knee OA, highlighting the importance of knee injury prevention programmes and secondary prevention strategies to prevent or delay knee OA development. PROSPERO registration number CRD42015016900.

AB - Objective To estimate knee osteoarthritis (OA) risk following anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury. Design Systematic review and meta-analysis. Data sources MEDLINE, Embase, SPORTDiscus, CINAHL and Web of Science until November 2018. Eligibility criteria for selecting studies Prospective or retrospective studies with at least 2-year follow-up including adults with ACL injury, meniscal injury or combined injuries. Knee OA was defined by radiographs or clinical diagnosis and compared with the contralateral knee or non-injured controls. Study appraisal and synthesis Risk of bias was assessed using the SIGN50 checklist. ORs for developing knee OA were estimated using random effects meta-analysis. Results 53 studies totalling â 1/41 million participants were included: 185 219 participants with ACL injury, mean age 28 years, 35% females, 98% surgically reconstructed; 83 267 participants with meniscal injury, mean age 38 years, 36% females, 22% confirmed meniscectomy and 73% unknown; 725 362 participants with combined injury, mean age 31 years, 26% females, 80% treated surgically. The OR of developing knee OA were 4.2 (95% CI 2.2 to 8.0; I 2 =92%), 6.3 (95% CI 3.8 to 10.5; I 2 =95%) and 6.4 (95% CI 4.9 to 8.3; I 2 =62%) for patients with ACL injury, meniscal injury and combined injuries, respectively. Conclusion The odds of developing knee OA following ACL injury are approximately four times higher compared with a non-injured knee. A meniscal injury and a combined injury affecting both the ACL and meniscus are associated with six times higher odds compared with a non-injured knee. Large inconsistency (eg, study design, follow-up period and comparator) and few high-quality studies suggest that future studies may change these estimates. Clinical relevance Patients sustaining a major knee injury have a substantially increased risk of developing knee OA, highlighting the importance of knee injury prevention programmes and secondary prevention strategies to prevent or delay knee OA development. PROSPERO registration number CRD42015016900.

KW - Anterior Cruciate Ligament Injuries/complications

KW - Humans

KW - Knee Injuries/complications

KW - Osteoarthritis, Knee/etiology

KW - Risk Factors

KW - Tibial Meniscus Injuries/complications

U2 - 10.1136/bjsports-2018-100022

DO - 10.1136/bjsports-2018-100022

M3 - Journal article

C2 - 31072840

VL - 53

SP - 1454

EP - 1463

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 23

ER -