Kinetics of cardiac troponin and other biomarkers in patients with ST elevation myocardial infarction

Jonas Henrik Kristensen*, Clara Amalie Wistisen Koczulab, Emil Anton Frandsen, Rasmus Bo Hasselbalch, Nina Strandkjær, Nicoline Jørgensen, Morten Østergaard, Peter Hasse Møller-Sørensen, Jens Christian Nilsson, Shoaib Afzal, Pia Rørbæk Kamstrup, Morten Dahl, Mustafa Vakur Bor, Ruth Frikke-Schmidt, Niklas Rye Jørgensen, Line Rode, Lene Holmvang, Jesper Kjærgaard, Lia Evi Bang, Julie FormanKim Dalhoff, Henning Bundgaard, Kasper Karmark Iversen

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Abstract

Objective: To examine changes in concentration, time-to-peak and the ensuing half-life of cardiac biomarkers in patients with myocardial infarction. Methods: Blood sampling was performed every third hour within 24 h after percutaneous coronary intervention (PCI) on a cohort of patients with ST elevation myocardial infarction. Cardiac troponin (cTn) was measured by the Dimension Vista, Vitros, Atellica, and Alinity high-sensitivity (hs) cTnI assays, and the Elecsys hs-cTnT assay. Further, creatine kinase (CK), myoglobin, creatine kinase MB (CKMB) and other biomarkers were analyzed. Results: A total of 36 patients completed blood sampling (median age 60 years, IQR 56.4–66.5 years; seven women, 19.4%). Hs-cTnI measured by the Vitros assay was the first hs-cTn to peak at 9.1 h (95%-CI 6.2–10.1) after PCI and 11.7 h (95%-CI 10.4–14.8) after symptoms onset. There were no notable differences between hs-cTn assays in regard to time-to-peak. Also, Vitros hs-cTnI reached the highest median ratio of concentration to upper reference level of nearly 2,000. The median half-life from peak concentration ranged from 7.6 h for myoglobin (CI 6.8–8.6) to 17.8 h for CK (CI 6.8–8.6). For hs-cTn assays the median T½ ranged from 12.4 h for the Vista hs-cTnI assay (95%-CI 11.0–14.1 h) to 17.3 h for the Elecsys hs-cTnT (95%-CI 14.9–20.8 h). Conclusions: This study updates knowledge on the kinetics of cardiac biomarkers in current clinical use. There was no notable difference in trajectories, time-to-peak or half-life between hs-cTn assays.

OriginalsprogEngelsk
Artikelnummer101250
TidsskriftIJC Heart and Vasculature
Vol/bind48
Antal sider8
ISSN2352-9067
DOI
StatusUdgivet - okt. 2023

Bibliografisk note

Funding Information:
This study was supported by funding from Candy's Foundation, Murermester Lauritz Peter Christensen og hustru Kirsten Sigrid's grant, the Research Council of Herlev and Gentofte Hospital, and the Mauritzen la Fountaine foundation. The benefactors had no influence on study design or execution.

Funding Information:
This study was supported by funding from Candy’s Foundation, Murermester Lauritz Peter Christensen og hustru Kirsten Sigrid’s grant, the Research Council of Herlev and Gentofte Hospital, and the Mauritzen la Fountaine foundation. The benefactors had no influence on study design or execution.

Publisher Copyright:
© 2023 The Authors

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