IVF and the exogenous progesterone-free luteal phase

Shahar Kol*, Peter Humaidan

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

PURPOSE OF REVIEW: In a conventional IVF cycle, final oocyte maturation and ovulation is triggered with a bolus of hCG, followed by progesterone-based luteal support that spans several weeks if pregnancy is achieved. This article summarizes several approaches of the exogenous progesterone-free luteal support in IVF. RECENT FINDINGS: Triggering ovulation with GnRH agonist may serve as an alternative to hCG, with well established advantages. In addition, the luteal phase can be individualized in order to achieve a more physiologic hormonal milieu, and a more patient friendly treatment, alleviating the burden of a lengthy exogenous progesterone therapy. SUMMARY: GnRH agonist trigger followed by a 'freeze all' policy is undoubtedly the best approach towards the 'OHSS-free clinic'. If fresh embryo transfer is considered well tolerated after GnRH agonist trigger, rescue of the corpora lutea by LH activity supplementation is mandatory. Herein we discuss the different approaches of corpus luteum rescue.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Obstetrics & Gynecology
Vol/bind33
Udgave nummer3
Sider (fra-til)188-195
ISSN1040-872X
DOI
StatusUdgivet - 1. jun. 2021

Bibliografisk note

Publisher Copyright:
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Fingeraftryk

Dyk ned i forskningsemnerne om 'IVF and the exogenous progesterone-free luteal phase'. Sammen danner de et unikt fingeraftryk.

Citationsformater