Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Frederik Faergemann Lau; Signe Bollerup; Frederik Engsig; Henrik Krarup; Lone Hagens Mygind; Jesper Bach Hansen; Lone Galmstrup Madsen; Peter Thielsen; Ulla Balslev; Lars Nørregaard Nielsen; Toke S Barfod; Mette Rye Clausen; Lise Hobolth; Alex Lund Laursen; Britta Tarp; Birgit T Roege; Jan Gerstoft; Peer Brehm Christensen; Nina Weis

doi:10.2147/CLEP.S361910

Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Frederik Faergemann Lau
, Signe Bollerup
, Frederik Engsig
, Henrik Krarup
, Lone Hagens Mygind
, Jesper Bach Hansen
, Lone Galmstrup Madsen
, Peter Thielsen
, Ulla Balslev
, Lars Nørregaard Nielsen
, Toke S Barfod
, Mette Rye Clausen
, Lise Hobolth
, Alex Lund Laursen
, Britta Tarp
, Birgit T Roege
, Jan Gerstoft
, Peer Brehm Christensen
, Nina Weis^*

^*Kontaktforfatter

Aalborg Universitetshospital
Sjællands Universitetshospital, Køge
Rigshospitalet
Diagnostic Imaging Center, Singen, Germany.
Københavns Universitet
Nordsjællands Hospital
Aarhus Universitetshospital
Københavns Universitetshospital
Hvidovre Hospital
Herlev Hospital

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

49 Downloads (Pure)

Abstract

Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.

Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.

Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).

Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

Originalsprog	Engelsk
Tidsskrift	Clinical Epidemiology
Vol/bind	14
Udgave nummer	14
Sider (fra-til)	879-888
ISSN	1179-1349
DOI	https://doi.org/10.2147/CLEP.S361910
Status	Udgivet - 2022

Bibliografisk note

Dokumenter og links

10.2147/CLEP.S361910Licens: CC BY-NC

Open access versionForlagets udgivne version, 833 KBLicens: CC BY-NC

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Lau, F. F., Bollerup, S., Engsig, F., Krarup, H., Mygind, L. H., Hansen, J. B., Madsen, L. G., Thielsen, P., Balslev, U., Nielsen, L. N., Barfod, T. S., Clausen, M. R., Hobolth, L., Laursen, A. L., Tarp, B., Roege, B. T., Gerstoft, J., Christensen, P. B., & Weis, N. (2022). Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study. Clinical Epidemiology, 14(14), 879-888. https://doi.org/10.2147/CLEP.S361910

@article{8bc3351f7ce34a7d840f8e65a6f07792,

title = "Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study",

abstract = "Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59\%) with CHB and 1058 (1,70\%) control-persons developed IHD. The crude IRR was 1.13 (95\% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95\% CI: 0.76-1.21).Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.",

keywords = "atherosclerosis, cardiovascular disease, coronary heart disease, general population, hepatitis B virus, ischemic heart disease, viral infection",

author = "Lau, \{Frederik Faergemann\} and Signe Bollerup and Frederik Engsig and Henrik Krarup and Mygind, \{Lone Hagens\} and Hansen, \{Jesper Bach\} and Madsen, \{Lone Galmstrup\} and Peter Thielsen and Ulla Balslev and Nielsen, \{Lars N{\o}rregaard\} and Barfod, \{Toke S\} and Clausen, \{Mette Rye\} and Lise Hobolth and Laursen, \{Alex Lund\} and Britta Tarp and Roege, \{Birgit T\} and Jan Gerstoft and Christensen, \{Peer Brehm\} and Nina Weis",

note = "{\textcopyright} 2022 Lau et al.",

year = "2022",

doi = "10.2147/CLEP.S361910",

language = "English",

volume = "14",

pages = "879--888",

journal = "Clinical Epidemiology",

issn = "1179-1349",

publisher = "Dove Medical Press",

number = "14",

}

Lau, FF, Bollerup, S, Engsig, F, Krarup, H, Mygind, LH, Hansen, JB, Madsen, LG, Thielsen, P, Balslev, U, Nielsen, LN, Barfod, TS, Clausen, MR, Hobolth, L, Laursen, AL, Tarp, B, Roege, BT, Gerstoft, J, Christensen, PB & Weis, N 2022, 'Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study', Clinical Epidemiology, bind 14, nr. 14, s. 879-888. https://doi.org/10.2147/CLEP.S361910

TY - JOUR

T1 - Ischemic Heart Disease in Chronic Hepatitis B

T2 - A Danish Nationwide Cohort Study

AU - Lau, Frederik Faergemann

AU - Bollerup, Signe

AU - Engsig, Frederik

AU - Krarup, Henrik

AU - Mygind, Lone Hagens

AU - Hansen, Jesper Bach

AU - Madsen, Lone Galmstrup

AU - Thielsen, Peter

AU - Balslev, Ulla

AU - Nielsen, Lars Nørregaard

AU - Barfod, Toke S

AU - Clausen, Mette Rye

AU - Hobolth, Lise

AU - Laursen, Alex Lund

AU - Tarp, Britta

AU - Roege, Birgit T

AU - Gerstoft, Jan

AU - Christensen, Peer Brehm

AU - Weis, Nina

PY - 2022

Y1 - 2022

N2 - Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

AB - Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

KW - atherosclerosis

KW - cardiovascular disease

KW - coronary heart disease

KW - general population

KW - hepatitis B virus

KW - ischemic heart disease

KW - viral infection

U2 - 10.2147/CLEP.S361910

DO - 10.2147/CLEP.S361910

M3 - Journal article

C2 - 35879942

SN - 1179-1349

VL - 14

SP - 879

EP - 888

JO - Clinical Epidemiology

JF - Clinical Epidemiology

IS - 14

ER -

Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Abstract

Bibliografisk note

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater