Is the total amount as important as localization and type of collagen in liver fibrosis due to steatohepatitis?

M A Karsdal, S Detlefsen, S J Daniels, M J Nielsen, A Krag, D Schuppan

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Is liver fibrosis just liver fibrosis? Or do the subtype of collagen, its spatial localization in the liver, its cell of origin, and the time point at which it is synthesized also matter? It is important, since the various collagen subtypes hold different informative values regarding reparative processes in the liver, and as collagens have also emerged as important signaling molecules (1). Novel data have challenged our perception of liver fibrosis and collagens, which may have important implications regarding the development of new biomarkers and anti-fibrotic interventions. The traditional histological analysis of liver biopsies using histochemical collagen stains, such as the Masson's Trichrome stain or the Sirius Red stain, group all triple helical collagen structures into one gross bucket. Importantly, these stains ignore many other quantitatively minor but nonetheless functionally and structurally relevant collagen and non-collagen extracellular matrix (ECM) components.

OriginalsprogEngelsk
TidsskriftHepatology (Baltimore, Md.)
ISSN0270-9139
DOI
StatusE-pub ahead of print - 25. sep. 2019

Fingeraftryk

Fatty Liver
Liver Cirrhosis
Liver
Coloring Agents

Citer dette

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title = "Is the total amount as important as localization and type of collagen in liver fibrosis due to steatohepatitis?",
abstract = "Is liver fibrosis just liver fibrosis? Or do the subtype of collagen, its spatial localization in the liver, its cell of origin, and the time point at which it is synthesized also matter? It is important, since the various collagen subtypes hold different informative values regarding reparative processes in the liver, and as collagens have also emerged as important signaling molecules (1). Novel data have challenged our perception of liver fibrosis and collagens, which may have important implications regarding the development of new biomarkers and anti-fibrotic interventions. The traditional histological analysis of liver biopsies using histochemical collagen stains, such as the Masson's Trichrome stain or the Sirius Red stain, group all triple helical collagen structures into one gross bucket. Importantly, these stains ignore many other quantitatively minor but nonetheless functionally and structurally relevant collagen and non-collagen extracellular matrix (ECM) components.",
author = "Karsdal, {M A} and S Detlefsen and Daniels, {S J} and Nielsen, {M J} and A Krag and D Schuppan",
note = "{\circledC} 2019 by the American Association for the Study of Liver Diseases.",
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T1 - Is the total amount as important as localization and type of collagen in liver fibrosis due to steatohepatitis?

AU - Karsdal, M A

AU - Detlefsen, S

AU - Daniels, S J

AU - Nielsen, M J

AU - Krag, A

AU - Schuppan, D

N1 - © 2019 by the American Association for the Study of Liver Diseases.

PY - 2019/9/25

Y1 - 2019/9/25

N2 - Is liver fibrosis just liver fibrosis? Or do the subtype of collagen, its spatial localization in the liver, its cell of origin, and the time point at which it is synthesized also matter? It is important, since the various collagen subtypes hold different informative values regarding reparative processes in the liver, and as collagens have also emerged as important signaling molecules (1). Novel data have challenged our perception of liver fibrosis and collagens, which may have important implications regarding the development of new biomarkers and anti-fibrotic interventions. The traditional histological analysis of liver biopsies using histochemical collagen stains, such as the Masson's Trichrome stain or the Sirius Red stain, group all triple helical collagen structures into one gross bucket. Importantly, these stains ignore many other quantitatively minor but nonetheless functionally and structurally relevant collagen and non-collagen extracellular matrix (ECM) components.

AB - Is liver fibrosis just liver fibrosis? Or do the subtype of collagen, its spatial localization in the liver, its cell of origin, and the time point at which it is synthesized also matter? It is important, since the various collagen subtypes hold different informative values regarding reparative processes in the liver, and as collagens have also emerged as important signaling molecules (1). Novel data have challenged our perception of liver fibrosis and collagens, which may have important implications regarding the development of new biomarkers and anti-fibrotic interventions. The traditional histological analysis of liver biopsies using histochemical collagen stains, such as the Masson's Trichrome stain or the Sirius Red stain, group all triple helical collagen structures into one gross bucket. Importantly, these stains ignore many other quantitatively minor but nonetheless functionally and structurally relevant collagen and non-collagen extracellular matrix (ECM) components.

U2 - 10.1002/hep.30969

DO - 10.1002/hep.30969

M3 - Review

JO - Hepatology

JF - Hepatology

SN - 0270-9139

ER -