Is Smoking a Risk Factor for Proliferative Diabetic Retinopathy in Type 1 Diabetes?

Mie Gaedt Thorlund, Mette Borg Madsen, Anders Green, Anne Katrin Sjølie, Jakob Grauslund

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Aim: The aim was to evaluate if smoking was a risk factor for proliferative retinopathy (PDR) in a 25-year follow-up study. Methods: 201 persons from a population-based cohort of Danish type 1 diabetic patients were examined at baseline and again 25 years later. At both examinations the patients were asked about their smoking habits. The level of retinopathy was evaluated by ophthalmoscopy at baseline and by nine 45-degree colour field fundus photos at the follow-up. Results: In multivariate analyses there was a trend that current smokers at baseline were more likely to develop PDR at the follow-up (odds ratio 1.90, 95% confidence interval 0.88-4.11, p = 0.10). Neither smoking status at the follow-up nor pack-years of smoking were associated with PDR. Conclusions: We found neither a beneficial nor a harmful effect of smoking on long-term incidence. Selective mortality among smokers and patients with PDR at baseline might provide at least part of the explanation for this.
OriginalsprogEngelsk
TidsskriftOphthalmologica
Vol/bind230
Udgave nummer1
Sider (fra-til)50-54
ISSN0030-3755
DOI
StatusUdgivet - 2013

Fingeraftryk

Diabetic Retinopathy
Smoking
Ophthalmoscopy
Habits
Multivariate Analysis
Color
Odds Ratio
Confidence Intervals
Incidence
Population

Citer dette

Gaedt Thorlund, Mie ; Borg Madsen, Mette ; Green, Anders ; Sjølie, Anne Katrin ; Grauslund, Jakob. / Is Smoking a Risk Factor for Proliferative Diabetic Retinopathy in Type 1 Diabetes?. I: Ophthalmologica. 2013 ; Bind 230, Nr. 1. s. 50-54.
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title = "Is Smoking a Risk Factor for Proliferative Diabetic Retinopathy in Type 1 Diabetes?",
abstract = "Aim: The aim was to evaluate if smoking was a risk factor for proliferative retinopathy (PDR) in a 25-year follow-up study. Methods: 201 persons from a population-based cohort of Danish type 1 diabetic patients were examined at baseline and again 25 years later. At both examinations the patients were asked about their smoking habits. The level of retinopathy was evaluated by ophthalmoscopy at baseline and by nine 45-degree colour field fundus photos at the follow-up. Results: In multivariate analyses there was a trend that current smokers at baseline were more likely to develop PDR at the follow-up (odds ratio 1.90, 95{\%} confidence interval 0.88-4.11, p = 0.10). Neither smoking status at the follow-up nor pack-years of smoking were associated with PDR. Conclusions: We found neither a beneficial nor a harmful effect of smoking on long-term incidence. Selective mortality among smokers and patients with PDR at baseline might provide at least part of the explanation for this.",
author = "{Gaedt Thorlund}, Mie and {Borg Madsen}, Mette and Anders Green and Sj{\o}lie, {Anne Katrin} and Jakob Grauslund",
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year = "2013",
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language = "English",
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pages = "50--54",
journal = "Ophthalmologica",
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Is Smoking a Risk Factor for Proliferative Diabetic Retinopathy in Type 1 Diabetes? / Gaedt Thorlund, Mie; Borg Madsen, Mette; Green, Anders; Sjølie, Anne Katrin; Grauslund, Jakob.

I: Ophthalmologica, Bind 230, Nr. 1, 2013, s. 50-54.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Is Smoking a Risk Factor for Proliferative Diabetic Retinopathy in Type 1 Diabetes?

AU - Gaedt Thorlund, Mie

AU - Borg Madsen, Mette

AU - Green, Anders

AU - Sjølie, Anne Katrin

AU - Grauslund, Jakob

N1 - Copyright © 2013 S. Karger AG, Basel.

PY - 2013

Y1 - 2013

N2 - Aim: The aim was to evaluate if smoking was a risk factor for proliferative retinopathy (PDR) in a 25-year follow-up study. Methods: 201 persons from a population-based cohort of Danish type 1 diabetic patients were examined at baseline and again 25 years later. At both examinations the patients were asked about their smoking habits. The level of retinopathy was evaluated by ophthalmoscopy at baseline and by nine 45-degree colour field fundus photos at the follow-up. Results: In multivariate analyses there was a trend that current smokers at baseline were more likely to develop PDR at the follow-up (odds ratio 1.90, 95% confidence interval 0.88-4.11, p = 0.10). Neither smoking status at the follow-up nor pack-years of smoking were associated with PDR. Conclusions: We found neither a beneficial nor a harmful effect of smoking on long-term incidence. Selective mortality among smokers and patients with PDR at baseline might provide at least part of the explanation for this.

AB - Aim: The aim was to evaluate if smoking was a risk factor for proliferative retinopathy (PDR) in a 25-year follow-up study. Methods: 201 persons from a population-based cohort of Danish type 1 diabetic patients were examined at baseline and again 25 years later. At both examinations the patients were asked about their smoking habits. The level of retinopathy was evaluated by ophthalmoscopy at baseline and by nine 45-degree colour field fundus photos at the follow-up. Results: In multivariate analyses there was a trend that current smokers at baseline were more likely to develop PDR at the follow-up (odds ratio 1.90, 95% confidence interval 0.88-4.11, p = 0.10). Neither smoking status at the follow-up nor pack-years of smoking were associated with PDR. Conclusions: We found neither a beneficial nor a harmful effect of smoking on long-term incidence. Selective mortality among smokers and patients with PDR at baseline might provide at least part of the explanation for this.

U2 - 10.1159/000350813

DO - 10.1159/000350813

M3 - Journal article

VL - 230

SP - 50

EP - 54

JO - Ophthalmologica

JF - Ophthalmologica

SN - 0030-3755

IS - 1

ER -