IP-10 can be measured in dried plasma spots in patients with chronic hepatitis C infection

Morten Ruhwald; Ellen Sloth Andersen; Peer Brehm Christensen; Belinda Klemmensen Moessner; Nina Weis

doi:10.1371/journal.pone.0045181

IP-10 can be measured in dried plasma spots in patients with chronic hepatitis C infection

Morten Ruhwald
, Ellen Sloth Andersen
, Peer Brehm Christensen
, Belinda Klemmensen Moessner
, Nina Weis

KI, OUH, Forskningsenhed for Infektionsmedicin (Odense)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p

Originalsprog	Engelsk
Tidsskrift	PLOS ONE
Vol/bind	7
Udgave nummer	9
Sider (fra-til)	e45181
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0045181
Status	Udgivet - 2012

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10.1371/journal.pone.0045181

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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abstract = "The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p",

author = "Morten Ruhwald and Andersen, \{Ellen Sloth\} and Christensen, \{Peer Brehm\} and Moessner, \{Belinda Klemmensen\} and Nina Weis",

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T1 - IP-10 can be measured in dried plasma spots in patients with chronic hepatitis C infection

AU - Ruhwald, Morten

AU - Andersen, Ellen Sloth

AU - Christensen, Peer Brehm

AU - Moessner, Belinda Klemmensen

AU - Weis, Nina

PY - 2012

Y1 - 2012

N2 - The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p

AB - The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p

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DO - 10.1371/journal.pone.0045181

M3 - Journal article

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SN - 1932-6203

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SP - e45181

JO - PLOS ONE

JF - PLOS ONE

IS - 9

ER -

IP-10 can be measured in dried plasma spots in patients with chronic hepatitis C infection

Abstract

Dokumenter og links

SDU link

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Citationsformater