Involvement of Inflammasome Components in Kidney Disease

Ana Karina Aranda-Rivera, Anjali Srivastava, Alfredo Cruz-Gregorio, José Pedraza-Chaverri, Shrikant R. Mulay, Alexandra Scholze*

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

172 Downloads (Pure)

Abstrakt

Inflammasomes are multiprotein complexes with an important role in the innate immune response. Canonical activation of inflammasomes results in caspase-1 activation and maturation of cytokines interleukin-1β and-18. These cytokines can elicit their effects through receptor activation, both locally within a certain tissue and systemically. Animal models of kidney diseases have shown inflammasome involvement in inflammation, pyroptosis and fibrosis. In particular, the inflamma-some component nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3) and related canonical mechanisms have been investigated. However, it has become increasingly clear that other inflammasome components are also of importance in kidney disease. Moreover, it is becoming obvious that the range of molecular interaction partners of inflammasome components in kidney diseases is wide. This review provides insights into these current areas of research, with special emphasis on the interaction of inflammasome components and redox signalling, endoplasmic reticulum stress, and mitochondrial function. We present our findings separately for acute kidney injury and chronic kidney disease. As we strictly divided the results into preclinical and clinical data, this review enables comparison of results from those complementary research specialities. However, it also reveals that knowledge gaps exist, especially in clinical acute kidney injury inflammasome re-search. Furthermore, patient comorbidities and treatments seem important drivers of inflammasome component alterations in human kidney disease.

OriginalsprogEngelsk
Artikelnummer246
TidsskriftAntioxidants
Vol/bind11
Udgave nummer2
ISSN2076-3921
DOI
StatusUdgivet - feb. 2022

Bibliografisk note

Funding Information:
This research was funded by Consejo Nacional de Ciencia y Tecnolog?a (CONACyT; grant number: A1-S-7495) and by Direcci?n General de Asuntos del Personal Acad?mico (DGAPA; grant number: IN200922).

Fingeraftryk

Dyk ned i forskningsemnerne om 'Involvement of Inflammasome Components in Kidney Disease'. Sammen danner de et unikt fingeraftryk.

Citationsformater