Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID-19 in Denmark

Martine S Nielsen; Ulrich Halekoh; Anders Perner; Trine Haberlandt; Nikolai Arnold- Larsen; Sarah Weihe; Ricardo S Garcia; Hanna Siegel; Christian Hagdrup; Mads R Skøtt; Anne-Mette S Jensen; Jonathan B Frische; Kasper Wethelund; Søren H Christiansen; Søren R Aagaard; Sofie Højlund; Bo Westergaard; Aage Christiansen; George Michagin; Marie S Worm; Ann-Kristine M Svendsen; Kirstine N la Cour; Trine B Jonassen; Jens U Jensen; Kasper M Sørensen; Nicolai Haase; Bodil S Rasmussen; Anne C Brøchner

doi:10.1111/aas.14571

Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID-19 in Denmark

Martine S Nielsen, Ulrich Halekoh, Anders Perner, Trine Haberlandt, Nikolai Arnold- Larsen, Sarah Weihe, Ricardo S Garcia, Hanna Siegel, Christian Hagdrup, Mads R Skøtt, Anne-Mette S Jensen, Jonathan B Frische, Kasper Wethelund, Søren H Christiansen, Søren R Aagaard, Sofie Højlund, Bo Westergaard, Aage Christiansen, George Michagin, Marie S WormAnn-Kristine M Svendsen, Kirstine N la Cour, Trine B Jonassen, Jens U Jensen, Kasper M Sørensen, Nicolai Haase, Bodil S Rasmussen, Anne C Brøchner

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Aim: To describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and the occurrence of barotrauma and prolonged ventilation in ICU patients with COVID-19 in Denmark, retrospectively.

Methods: All ICUs admitting COVID-19 patients in Denmark from 10 March 2020 to 2 April 2021 were invited to participate. All patients with COVID-19 who received invasive mechanical ventilation were included and data was retrospectively collected from electronic patient records.

Results: A total of 774 patients were invasively ventilated during the first two waves and included; 70% were males and the median age was 69 years. 340 (51.5%) of patients never exceeded tidal volumes of 8 mL/kg. For all patients, tidal volumes under 8 mL/kg were applied in 77.6% (IQR 54.5%-96.2%) of the time on ventilator in the ICU; plateau pressure was below 30 cm H2O in 125 (80.6%) patients; prone positioning was used in 44.7% of patients. In ICU, 169 of 774 (21.8%) patients experienced barotrauma and 220 (28.4%) prolonged ventilation. At 90 days, 306 (39.5%) had died.

Conclusions: Lung protective ventilation and prone positioning were used in many of the Danish ICU patients with COVID-19, but barotrauma, prolonged ventilation and death occurred frequently.

Originalsprog	Engelsk
Artikelnummer	e14571
Tidsskrift	Acta Anaesthesiologica Scandinavica
Vol/bind	69
Udgave nummer	2
ISSN	0001-5172
DOI	https://doi.org/10.1111/aas.14571
Status	Udgivet - feb. 2025

Bibliografisk note

Emneord

COVID-19
adverse events
barotrauma
core strategies
mechanical ventilation

Dokumenter og links

10.1111/aas.14571

Citationsformater

Nielsen, M. S., Halekoh, U., Perner, A., Haberlandt, T., Larsen, N. A., Weihe, S., Garcia, R. S., Siegel, H., Hagdrup, C., Skøtt, M. R., Jensen, A.-M. S., Frische, J. B., Wethelund, K., Christiansen, S. H., Aagaard, S. R., Højlund, S., Westergaard, B., Christiansen, A., Michagin, G., ... Brøchner, A. C. (2025). Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID-19 in Denmark. Acta Anaesthesiologica Scandinavica, 69(2), Artikel e14571. https://doi.org/10.1111/aas.14571

@article{0ed9d67cf32e4a75a989a096e6c336c2,

title = "Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID-19 in Denmark",

abstract = "AIM: To describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and the occurrence of barotrauma and prolonged ventilation in ICU patients with COVID-19 in Denmark, retrospectively.METHODS: All ICUs admitting COVID-19 patients in Denmark from 10 March 2020 to 2 April 2021 were invited to participate. All patients with COVID-19 who received invasive mechanical ventilation were included and data was retrospectively collected from electronic patient records.RESULTS: A total of 774 patients were invasively ventilated during the first two waves and included; 70% were males and the median age was 69 years. 340 (51.5%) of patients never exceeded tidal volumes of 8 mL/kg. For all patients, tidal volumes under 8 mL/kg were applied in 77.6% (IQR 54.5%-96.2%) of the time on ventilator in the ICU; plateau pressure was below 30 cm H2O in 125 (80.6%) patients; prone positioning was used in 44.7% of patients. In ICU, 169 of 774 (21.8%) patients experienced barotrauma and 220 (28.4%) prolonged ventilation. At 90 days, 306 (39.5%) had died.CONCLUSIONS: Lung protective ventilation and prone positioning were used in many of the Danish ICU patients with COVID-19, but barotrauma, prolonged ventilation and death occurred frequently.",

keywords = "Humans, COVID-19/therapy, Male, Denmark/epidemiology, Female, Respiration, Artificial, Aged, Retrospective Studies, Middle Aged, Intensive Care Units, Barotrauma/etiology, Tidal Volume, Prone Position, Aged, 80 and over, Critical Care/methods, mechanical ventilation, barotrauma, adverse events, core strategies, COVID-19, COVID-19, adverse events, barotrauma, core strategies, mechanical ventilation",

author = "Nielsen, {Martine S} and Ulrich Halekoh and Anders Perner and Trine Haberlandt and Larsen, {Nikolai Arnold-} and Sarah Weihe and Garcia, {Ricardo S} and Hanna Siegel and Christian Hagdrup and Sk{\o}tt, {Mads R} and Jensen, {Anne-Mette S} and Frische, {Jonathan B} and Kasper Wethelund and Christiansen, {S{\o}ren H} and Aagaard, {S{\o}ren R} and Sofie H{\o}jlund and Bo Westergaard and Aage Christiansen and George Michagin and Worm, {Marie S} and Svendsen, {Ann-Kristine M} and {la Cour}, {Kirstine N} and Jonassen, {Trine B} and Jensen, {Jens U} and S{\o}rensen, {Kasper M} and Nicolai Haase and Rasmussen, {Bodil S} and Br{\o}chner, {Anne C}",

note = "{\textcopyright} 2025 Acta Anaesthesiologica Scandinavica Foundation.",

year = "2025",

month = feb,

doi = "10.1111/aas.14571",

language = "English",

volume = "69",

journal = "Acta Anaesthesiologica Scandinavica",

issn = "0001-5172",

publisher = "Blackwell Munksgaard",

number = "2",

}

Nielsen, MS , Halekoh, U, Perner, A, Haberlandt, T, Larsen, NA, Weihe, S, Garcia, RS, Siegel, H, Hagdrup, C, Skøtt, MR, Jensen, A-MS, Frische, JB, Wethelund, K, Christiansen, SH, Aagaard, SR, Højlund, S, Westergaard, B, Christiansen, A, Michagin, G, Worm, MS, Svendsen, A-KM, la Cour, KN, Jonassen, TB, Jensen, JU, Sørensen, KM, Haase, N, Rasmussen, BS & Brøchner, AC 2025, 'Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID-19 in Denmark', Acta Anaesthesiologica Scandinavica, bind 69, nr. 2, e14571. https://doi.org/10.1111/aas.14571

TY - JOUR

T1 - Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID-19 in Denmark

AU - Nielsen, Martine S

AU - Halekoh, Ulrich

AU - Perner, Anders

AU - Haberlandt, Trine

AU - Larsen, Nikolai Arnold-

AU - Weihe, Sarah

AU - Garcia, Ricardo S

AU - Siegel, Hanna

AU - Hagdrup, Christian

AU - Skøtt, Mads R

AU - Jensen, Anne-Mette S

AU - Frische, Jonathan B

AU - Wethelund, Kasper

AU - Christiansen, Søren H

AU - Aagaard, Søren R

AU - Højlund, Sofie

AU - Westergaard, Bo

AU - Christiansen, Aage

AU - Michagin, George

AU - Worm, Marie S

AU - Svendsen, Ann-Kristine M

AU - la Cour, Kirstine N

AU - Jonassen, Trine B

AU - Jensen, Jens U

AU - Sørensen, Kasper M

AU - Haase, Nicolai

AU - Rasmussen, Bodil S

AU - Brøchner, Anne C

PY - 2025/2

Y1 - 2025/2

N2 - AIM: To describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and the occurrence of barotrauma and prolonged ventilation in ICU patients with COVID-19 in Denmark, retrospectively.METHODS: All ICUs admitting COVID-19 patients in Denmark from 10 March 2020 to 2 April 2021 were invited to participate. All patients with COVID-19 who received invasive mechanical ventilation were included and data was retrospectively collected from electronic patient records.RESULTS: A total of 774 patients were invasively ventilated during the first two waves and included; 70% were males and the median age was 69 years. 340 (51.5%) of patients never exceeded tidal volumes of 8 mL/kg. For all patients, tidal volumes under 8 mL/kg were applied in 77.6% (IQR 54.5%-96.2%) of the time on ventilator in the ICU; plateau pressure was below 30 cm H2O in 125 (80.6%) patients; prone positioning was used in 44.7% of patients. In ICU, 169 of 774 (21.8%) patients experienced barotrauma and 220 (28.4%) prolonged ventilation. At 90 days, 306 (39.5%) had died.CONCLUSIONS: Lung protective ventilation and prone positioning were used in many of the Danish ICU patients with COVID-19, but barotrauma, prolonged ventilation and death occurred frequently.

AB - AIM: To describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and the occurrence of barotrauma and prolonged ventilation in ICU patients with COVID-19 in Denmark, retrospectively.METHODS: All ICUs admitting COVID-19 patients in Denmark from 10 March 2020 to 2 April 2021 were invited to participate. All patients with COVID-19 who received invasive mechanical ventilation were included and data was retrospectively collected from electronic patient records.RESULTS: A total of 774 patients were invasively ventilated during the first two waves and included; 70% were males and the median age was 69 years. 340 (51.5%) of patients never exceeded tidal volumes of 8 mL/kg. For all patients, tidal volumes under 8 mL/kg were applied in 77.6% (IQR 54.5%-96.2%) of the time on ventilator in the ICU; plateau pressure was below 30 cm H2O in 125 (80.6%) patients; prone positioning was used in 44.7% of patients. In ICU, 169 of 774 (21.8%) patients experienced barotrauma and 220 (28.4%) prolonged ventilation. At 90 days, 306 (39.5%) had died.CONCLUSIONS: Lung protective ventilation and prone positioning were used in many of the Danish ICU patients with COVID-19, but barotrauma, prolonged ventilation and death occurred frequently.

KW - Humans

KW - COVID-19/therapy

KW - Male

KW - Denmark/epidemiology

KW - Female

KW - Respiration, Artificial

KW - Aged

KW - Retrospective Studies

KW - Middle Aged

KW - Intensive Care Units

KW - Barotrauma/etiology

KW - Tidal Volume

KW - Prone Position

KW - Aged, 80 and over

KW - Critical Care/methods

KW - mechanical ventilation

KW - barotrauma

KW - adverse events

KW - core strategies

KW - COVID-19

KW - adverse events

KW - barotrauma

KW - core strategies

KW - mechanical ventilation

U2 - 10.1111/aas.14571

DO - 10.1111/aas.14571

M3 - Journal article

C2 - 39749940

SN - 0001-5172

VL - 69

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 2

M1 - e14571

ER -

Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID-19 in Denmark

Abstract

Bibliografisk note

Emneord

Dokumenter og links

Fingeraftryk

Citationsformater