Intra- and interobserver reliability and intra-catheter reproducibility using frequency domain optical coherence tomography for the evaluation of morphometric stent parameters and qualitative assessment of stent strut coverage

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Resumé

PURPOSE: Frequency-domain optical coherence tomography (FD-OCT) is a high-resolution imaging tool (~10-15μm), which enables near-histological in-vivo images of the coronary vessel wall. The use of the technique is increasing, both for research- and clinical purposes. This study sought to investigate the intra- and interobserver reliability, as well as the intra-catheter reproducibility of quantitative FD-OCT-assessment of morphometric stent parameters and qualitative FD-OCT-evaluation of strut coverage in 10 randomly selected 6-month follow-up Nobori® biolimus-eluting stents (N-BESs).

METHODS: Ten N-BESs (213 cross sectional areas (CSAs) and 1897 struts) imaged with OCT 6months post-implantation were randomly selected and analyzed by 2 experienced analysts, and the same 10 N-BESs were analyzed by one of the analysts 3months later. Further, 2 consecutive pullbacks randomly performed in another 10 N-BESs (219 CSAs and 1860 struts) were independently assessed by one of the analysts.

RESULTS: The intraobserver variability with regard to relative difference of mean luminal area and mean stent area at the CSA-level was very low: 0.1%±1.4% and 0.5%±3.2%. Interobserver variability also proved to be low: -2.1%±3.3% and 2.1%±4.6%, and moreover, very restricted intra-catheter variation was observed: 0.02%±6.8% and -0.18%±5.2%. The intraobserver-, interobserver- and intra-catheter reliability for the qualitative evaluation of strut coverage was found to be: kappa (κ)=0.91 (95% confidence interval (CI): 0.88-0.93, p<0.01), κ=0.88 (95% CI: 0.85-0.91, p<0.01), and κ=0.73 (95% CI: 0.68-0.78, p<0.01), respectively.

CONCLUSIONS: FD-OCT is a reproducible and reliable imaging tool for quantitative evaluation of stented coronary segments, and for qualitative assessment of strut coverage.

OriginalsprogEngelsk
TidsskriftCardiovascular Revascularization Medicine
Vol/bind16
Udgave nummer8
Sider (fra-til)469-477
ISSN1553-8389
DOI
StatusUdgivet - 2015

Fingeraftryk

Optical Coherence Tomography
Stents
Catheters
Observer Variation
Confidence Intervals
Research

Citer dette

@article{10198499c9f34a188a31bb3cf98316d3,
title = "Intra- and interobserver reliability and intra-catheter reproducibility using frequency domain optical coherence tomography for the evaluation of morphometric stent parameters and qualitative assessment of stent strut coverage",
abstract = "PURPOSE: Frequency-domain optical coherence tomography (FD-OCT) is a high-resolution imaging tool (~10-15μm), which enables near-histological in-vivo images of the coronary vessel wall. The use of the technique is increasing, both for research- and clinical purposes. This study sought to investigate the intra- and interobserver reliability, as well as the intra-catheter reproducibility of quantitative FD-OCT-assessment of morphometric stent parameters and qualitative FD-OCT-evaluation of strut coverage in 10 randomly selected 6-month follow-up Nobori{\circledR} biolimus-eluting stents (N-BESs).METHODS: Ten N-BESs (213 cross sectional areas (CSAs) and 1897 struts) imaged with OCT 6months post-implantation were randomly selected and analyzed by 2 experienced analysts, and the same 10 N-BESs were analyzed by one of the analysts 3months later. Further, 2 consecutive pullbacks randomly performed in another 10 N-BESs (219 CSAs and 1860 struts) were independently assessed by one of the analysts.RESULTS: The intraobserver variability with regard to relative difference of mean luminal area and mean stent area at the CSA-level was very low: 0.1{\%}±1.4{\%} and 0.5{\%}±3.2{\%}. Interobserver variability also proved to be low: -2.1{\%}±3.3{\%} and 2.1{\%}±4.6{\%}, and moreover, very restricted intra-catheter variation was observed: 0.02{\%}±6.8{\%} and -0.18{\%}±5.2{\%}. The intraobserver-, interobserver- and intra-catheter reliability for the qualitative evaluation of strut coverage was found to be: kappa (κ)=0.91 (95{\%} confidence interval (CI): 0.88-0.93, p<0.01), κ=0.88 (95{\%} CI: 0.85-0.91, p<0.01), and κ=0.73 (95{\%} CI: 0.68-0.78, p<0.01), respectively.CONCLUSIONS: FD-OCT is a reproducible and reliable imaging tool for quantitative evaluation of stented coronary segments, and for qualitative assessment of strut coverage.",
author = "Lisbeth Antonsen and Per Thayssen and Anders Junker and Veien, {Karsten Tange} and Hansen, {Henrik Steen} and Hansen, {Knud N{\o}rregaard} and Mikkel Hougaard and Jensen, {Lisette Okkels}",
note = "Copyright {\circledC} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
doi = "10.1016/j.carrev.2015.08.010",
language = "English",
volume = "16",
pages = "469--477",
journal = "Cardiovascular Revascularization Medicine",
issn = "1553-8389",
publisher = "Elsevier",
number = "8",

}

TY - JOUR

T1 - Intra- and interobserver reliability and intra-catheter reproducibility using frequency domain optical coherence tomography for the evaluation of morphometric stent parameters and qualitative assessment of stent strut coverage

AU - Antonsen, Lisbeth

AU - Thayssen, Per

AU - Junker, Anders

AU - Veien, Karsten Tange

AU - Hansen, Henrik Steen

AU - Hansen, Knud Nørregaard

AU - Hougaard, Mikkel

AU - Jensen, Lisette Okkels

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015

Y1 - 2015

N2 - PURPOSE: Frequency-domain optical coherence tomography (FD-OCT) is a high-resolution imaging tool (~10-15μm), which enables near-histological in-vivo images of the coronary vessel wall. The use of the technique is increasing, both for research- and clinical purposes. This study sought to investigate the intra- and interobserver reliability, as well as the intra-catheter reproducibility of quantitative FD-OCT-assessment of morphometric stent parameters and qualitative FD-OCT-evaluation of strut coverage in 10 randomly selected 6-month follow-up Nobori® biolimus-eluting stents (N-BESs).METHODS: Ten N-BESs (213 cross sectional areas (CSAs) and 1897 struts) imaged with OCT 6months post-implantation were randomly selected and analyzed by 2 experienced analysts, and the same 10 N-BESs were analyzed by one of the analysts 3months later. Further, 2 consecutive pullbacks randomly performed in another 10 N-BESs (219 CSAs and 1860 struts) were independently assessed by one of the analysts.RESULTS: The intraobserver variability with regard to relative difference of mean luminal area and mean stent area at the CSA-level was very low: 0.1%±1.4% and 0.5%±3.2%. Interobserver variability also proved to be low: -2.1%±3.3% and 2.1%±4.6%, and moreover, very restricted intra-catheter variation was observed: 0.02%±6.8% and -0.18%±5.2%. The intraobserver-, interobserver- and intra-catheter reliability for the qualitative evaluation of strut coverage was found to be: kappa (κ)=0.91 (95% confidence interval (CI): 0.88-0.93, p<0.01), κ=0.88 (95% CI: 0.85-0.91, p<0.01), and κ=0.73 (95% CI: 0.68-0.78, p<0.01), respectively.CONCLUSIONS: FD-OCT is a reproducible and reliable imaging tool for quantitative evaluation of stented coronary segments, and for qualitative assessment of strut coverage.

AB - PURPOSE: Frequency-domain optical coherence tomography (FD-OCT) is a high-resolution imaging tool (~10-15μm), which enables near-histological in-vivo images of the coronary vessel wall. The use of the technique is increasing, both for research- and clinical purposes. This study sought to investigate the intra- and interobserver reliability, as well as the intra-catheter reproducibility of quantitative FD-OCT-assessment of morphometric stent parameters and qualitative FD-OCT-evaluation of strut coverage in 10 randomly selected 6-month follow-up Nobori® biolimus-eluting stents (N-BESs).METHODS: Ten N-BESs (213 cross sectional areas (CSAs) and 1897 struts) imaged with OCT 6months post-implantation were randomly selected and analyzed by 2 experienced analysts, and the same 10 N-BESs were analyzed by one of the analysts 3months later. Further, 2 consecutive pullbacks randomly performed in another 10 N-BESs (219 CSAs and 1860 struts) were independently assessed by one of the analysts.RESULTS: The intraobserver variability with regard to relative difference of mean luminal area and mean stent area at the CSA-level was very low: 0.1%±1.4% and 0.5%±3.2%. Interobserver variability also proved to be low: -2.1%±3.3% and 2.1%±4.6%, and moreover, very restricted intra-catheter variation was observed: 0.02%±6.8% and -0.18%±5.2%. The intraobserver-, interobserver- and intra-catheter reliability for the qualitative evaluation of strut coverage was found to be: kappa (κ)=0.91 (95% confidence interval (CI): 0.88-0.93, p<0.01), κ=0.88 (95% CI: 0.85-0.91, p<0.01), and κ=0.73 (95% CI: 0.68-0.78, p<0.01), respectively.CONCLUSIONS: FD-OCT is a reproducible and reliable imaging tool for quantitative evaluation of stented coronary segments, and for qualitative assessment of strut coverage.

U2 - 10.1016/j.carrev.2015.08.010

DO - 10.1016/j.carrev.2015.08.010

M3 - Journal article

C2 - 26475731

VL - 16

SP - 469

EP - 477

JO - Cardiovascular Revascularization Medicine

JF - Cardiovascular Revascularization Medicine

SN - 1553-8389

IS - 8

ER -