Intestinal first pass metabolism of midazolam in liver cirrhosis: effect of grapefruit juice

Vibeke Andersen*, Natalie Pedersen, Niels-Erik Larsen, Jesper Sonne, Steen Larsen

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Abstrakt

Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs. For example, it has been shown that the oral bioavailability of midazolam, a CYP3A4 substrate, increased by 52% in healthy subjects after ingestion of grapefruit juice. However, this interaction has not been studied in patients with impaired liver function. Accordingly, the effect of grapefruit juice on the AUC of midazolam and the metabolite alpha-hydroxymidazolam was studied in patients with cirrhosis of the liver.
OriginalsprogEngelsk
TidsskriftBritish Journal of Clinical Pharmacology
Vol/bind54
Udgave nummer2
Sider (fra-til)120-124
ISSN0306-5251
DOI
StatusUdgivet - aug. 2002
Udgivet eksterntJa

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