Interpretation of Tandem Mass Spectrometry (MS-MS) Spectra for Peptide Analysis

Karin Hjernø, Peter Højrup*

*Kontaktforfatter

Publikation: Kapitel i bog/rapport/konference-proceedingKapitel i bogForskning

Abstract

The aim of this chapter is to give a short introduction to peptide analysis by mass spectrometry (MS) and interpretation of fragment mass spectra. Through examples and guidelines, we will demonstrate how to understand and validate search results and how to perform de novo sequencing based on the often very complex fragmentation pattern obtained by tandem mass spectrometry (also referred to as MSMS). The focus will be on simple rules for interpretation of MSMS spectra of tryptic as well as non-tryptic peptides.

OriginalsprogEngelsk
TitelPeptide Antibodies
RedaktørerG Houen
Vol/bind2821
ForlagHumana Press
Publikationsdato2024
Sider91-110
ISBN (Trykt)978-1-0716-3913-9
ISBN (Elektronisk)978-1-0716-3914-6
DOI
StatusUdgivet - 2024
NavnMethods in Molecular Biology
Vol/bind2821
ISSN1064-3745

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