Intercolumnar synchronization of neuronal activity in rat barrel cortex during patterned airjet stimulation: A laminar analysis

Mengliang Zhang, Kevin D. Alloway*

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Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We used cross-correlation analysis to characterize the incidence and strength of stimulus-induced neuronal synchronization in different layers of SI barrel cortex and as a function of neuronal location in different barrel columns. To reduce the possibility of evoking responses that were coordinated by simultaneous whisker movements, multiple whiskers were sequentially stimulated with airjets that moved back-and-forth across the peripheral whisker pad. From a sample of 627 neurons, we characterized 1,182 neuron pairs and found that 687 (58.1%) of these displayed significant peaks of synchronized activity that exceeded the 99.9% confidence limits. Whereas 88% of the infragranular neuron pairs were synchronized during whisker stimulation, only 30% of the neuron pairs in the granular or supra-granular layers displayed synchronized responses. The strength of synchronization, as measured by the correlation coefficient, was significantly higher in the infragranular layers than in the other layers. These results indicate that synchronized outputs from the infragranular layers do not depend on synchronized inputs from the upper cortical layers. We also found that synchronization varies with the spatial configuration of the neurons and is strongest for neuron pairs residing in the same row. Given the dense local projections between neighboring barrel columns in the same row, our results indicate that neuronal synchronization is greatest when stimuli simultaneously activate those peripheral receptors whose cortical representations are most densely interconnected. Finally, we compared the present results with synchronized responses in somatosensory (SI) barrel cortex that were evoked by controlled, pulsatile whisker movements in a previous study. We conclude that highly-controlled whisker stimulation increases stimulus coordination and may exaggerate the incidence and strength of synchronization among neurons in the granular or supragranular layers.

OriginalsprogEngelsk
TidsskriftExperimental Brain Research
Vol/bind169
Udgave nummer3
Sider (fra-til)311-325
ISSN0014-4819
DOI
StatusUdgivet - 1. mar. 2006
Udgivet eksterntJa

Fingeraftryk

Vibrissae
Neurons
Incidence

Citer dette

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title = "Intercolumnar synchronization of neuronal activity in rat barrel cortex during patterned airjet stimulation: A laminar analysis",
abstract = "We used cross-correlation analysis to characterize the incidence and strength of stimulus-induced neuronal synchronization in different layers of SI barrel cortex and as a function of neuronal location in different barrel columns. To reduce the possibility of evoking responses that were coordinated by simultaneous whisker movements, multiple whiskers were sequentially stimulated with airjets that moved back-and-forth across the peripheral whisker pad. From a sample of 627 neurons, we characterized 1,182 neuron pairs and found that 687 (58.1{\%}) of these displayed significant peaks of synchronized activity that exceeded the 99.9{\%} confidence limits. Whereas 88{\%} of the infragranular neuron pairs were synchronized during whisker stimulation, only 30{\%} of the neuron pairs in the granular or supra-granular layers displayed synchronized responses. The strength of synchronization, as measured by the correlation coefficient, was significantly higher in the infragranular layers than in the other layers. These results indicate that synchronized outputs from the infragranular layers do not depend on synchronized inputs from the upper cortical layers. We also found that synchronization varies with the spatial configuration of the neurons and is strongest for neuron pairs residing in the same row. Given the dense local projections between neighboring barrel columns in the same row, our results indicate that neuronal synchronization is greatest when stimuli simultaneously activate those peripheral receptors whose cortical representations are most densely interconnected. Finally, we compared the present results with synchronized responses in somatosensory (SI) barrel cortex that were evoked by controlled, pulsatile whisker movements in a previous study. We conclude that highly-controlled whisker stimulation increases stimulus coordination and may exaggerate the incidence and strength of synchronization among neurons in the granular or supragranular layers.",
keywords = "Barrel cortex, Cross-correlation analysis, Intracortical connections, Neuronal synchronization, Stimulus coordination",
author = "Mengliang Zhang and Alloway, {Kevin D.}",
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Intercolumnar synchronization of neuronal activity in rat barrel cortex during patterned airjet stimulation : A laminar analysis. / Zhang, Mengliang; Alloway, Kevin D.

I: Experimental Brain Research, Bind 169, Nr. 3, 01.03.2006, s. 311-325.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Intercolumnar synchronization of neuronal activity in rat barrel cortex during patterned airjet stimulation

T2 - A laminar analysis

AU - Zhang, Mengliang

AU - Alloway, Kevin D.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - We used cross-correlation analysis to characterize the incidence and strength of stimulus-induced neuronal synchronization in different layers of SI barrel cortex and as a function of neuronal location in different barrel columns. To reduce the possibility of evoking responses that were coordinated by simultaneous whisker movements, multiple whiskers were sequentially stimulated with airjets that moved back-and-forth across the peripheral whisker pad. From a sample of 627 neurons, we characterized 1,182 neuron pairs and found that 687 (58.1%) of these displayed significant peaks of synchronized activity that exceeded the 99.9% confidence limits. Whereas 88% of the infragranular neuron pairs were synchronized during whisker stimulation, only 30% of the neuron pairs in the granular or supra-granular layers displayed synchronized responses. The strength of synchronization, as measured by the correlation coefficient, was significantly higher in the infragranular layers than in the other layers. These results indicate that synchronized outputs from the infragranular layers do not depend on synchronized inputs from the upper cortical layers. We also found that synchronization varies with the spatial configuration of the neurons and is strongest for neuron pairs residing in the same row. Given the dense local projections between neighboring barrel columns in the same row, our results indicate that neuronal synchronization is greatest when stimuli simultaneously activate those peripheral receptors whose cortical representations are most densely interconnected. Finally, we compared the present results with synchronized responses in somatosensory (SI) barrel cortex that were evoked by controlled, pulsatile whisker movements in a previous study. We conclude that highly-controlled whisker stimulation increases stimulus coordination and may exaggerate the incidence and strength of synchronization among neurons in the granular or supragranular layers.

AB - We used cross-correlation analysis to characterize the incidence and strength of stimulus-induced neuronal synchronization in different layers of SI barrel cortex and as a function of neuronal location in different barrel columns. To reduce the possibility of evoking responses that were coordinated by simultaneous whisker movements, multiple whiskers were sequentially stimulated with airjets that moved back-and-forth across the peripheral whisker pad. From a sample of 627 neurons, we characterized 1,182 neuron pairs and found that 687 (58.1%) of these displayed significant peaks of synchronized activity that exceeded the 99.9% confidence limits. Whereas 88% of the infragranular neuron pairs were synchronized during whisker stimulation, only 30% of the neuron pairs in the granular or supra-granular layers displayed synchronized responses. The strength of synchronization, as measured by the correlation coefficient, was significantly higher in the infragranular layers than in the other layers. These results indicate that synchronized outputs from the infragranular layers do not depend on synchronized inputs from the upper cortical layers. We also found that synchronization varies with the spatial configuration of the neurons and is strongest for neuron pairs residing in the same row. Given the dense local projections between neighboring barrel columns in the same row, our results indicate that neuronal synchronization is greatest when stimuli simultaneously activate those peripheral receptors whose cortical representations are most densely interconnected. Finally, we compared the present results with synchronized responses in somatosensory (SI) barrel cortex that were evoked by controlled, pulsatile whisker movements in a previous study. We conclude that highly-controlled whisker stimulation increases stimulus coordination and may exaggerate the incidence and strength of synchronization among neurons in the granular or supragranular layers.

KW - Barrel cortex

KW - Cross-correlation analysis

KW - Intracortical connections

KW - Neuronal synchronization

KW - Stimulus coordination

U2 - 10.1007/s00221-005-0152-5

DO - 10.1007/s00221-005-0152-5

M3 - Journal article

C2 - 16284753

AN - SCOPUS:33644832646

VL - 169

SP - 311

EP - 325

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 3

ER -