Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference

Nanna J Olsen, Lars Ängquist, Sofus C Larsen, Allan Linneberg, Tea Skaaby, Lise Lotte N Husemoen, Ulla Toft, Anne Tjønneland, Jytte Halkjær, Torben Hansen, Oluf Pedersen, Kim Overvad, Tarunveer Singh Ahluwalia, Thorkild I. A. Sørensen, B. L. Heitmann

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Intake of sugar-sweetened beverages is associated with obesity, and this association may be modified by a genetic predisposition to obesity. Objective: We examined the interactions between a molecular genetic predisposition to various aspects of obesity and the consumption of soft drinks, which are a major part of sugar-sweetened beverages, in relation to changes in adiposity measures. Design: A total of 4765 individuals were included in the study. On the basis of 50 obesity- Associated single nucleotide polymorphisms that are associated with body mass index (BMI), waist circumference (WC), or the waist- To-hip ratio adjusted for BMI (WHRBMI), the following 4 genetic predisposition scores (GRSs) were constructed: A complete genetic predisposition score including all 50 single nucleotide polymorphisms (GRSComplete), a genetic predisposition score including BMI- Associated single nucleotide polymorphisms (GRSBMI), a genetic predisposition score including waist circumference- Associated single nucleotide polymorphisms (GRSWC), and a genetic predisposition score including the waist- To-hip ratio adjusted for BMI- Associated single nucleotide polymorphisms (GRSWHR). Associations between soft drink intake and the annual change (D) in body weight (BW), WC, or waist circumference adjusted for BMI (WCBMI) and possible interactions with the GRSs were examined with the use of linear regression analyses and meta- Analyses. Results: For each soft drink serving per day, soft drink consumption was significantly associated with a higher DBWof 0.07 kg/y (95% CI: 0.01, 0.13 kg/y; P = 0.020) but not with the DWC or DWCBMI. In analyses of the DBW, we showed an interaction only with the GRSWC (per risk allele for each soft drink serving per day: 20.06 kg/y; 95% CI: 20.10, 20.02 kg/y; P = 0.006). In analyses of the DWC, we showed interactions only with the GRSBMI and GRSComplete [per risk allele for each soft drink serving per day: 0.05 cm/y (95% CI: 0.02, 0.09 cm/y; P = 0.001) and 0.05 cm/y (95% CI: 0.02, 0.07 cm/y; P = 0.001), respectively]. Nearly identical results were observed in analyses of the DWCBMI. Conclusions: A genetic predisposition to a high WC may attenuate the association between soft drink intake and BW gain. A genetic predisposition to high BMI as well as a genetic predisposition to high BMI, WC, and WHRBMI combined may strengthen the association between soft drink intake and WC gain. However, the public health impact may be limited. Am J Clin Nutr 2016;104:816-26. © 2016 American Society for Nutrition.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Clinical Nutrition
Vol/bind104
Udgave nummer3
Sider (fra-til)816-826
ISSN0002-9165
DOI
StatusUdgivet - 2016

Bibliografisk note

Export Date: 22 March 2017 CODEN: AJCNA

Citer dette

Olsen, Nanna J ; Ängquist, Lars ; Larsen, Sofus C ; Linneberg, Allan ; Skaaby, Tea ; Husemoen, Lise Lotte N ; Toft, Ulla ; Tjønneland, Anne ; Halkjær, Jytte ; Hansen, Torben ; Pedersen, Oluf ; Overvad, Kim ; Ahluwalia, Tarunveer Singh ; I. A. Sørensen, Thorkild ; Heitmann, B. L. / Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference. I: American Journal of Clinical Nutrition. 2016 ; Bind 104, Nr. 3. s. 816-826.
@article{7ef5ff0fea3f48c1ad49bc7078d35caa,
title = "Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference",
abstract = "Background: Intake of sugar-sweetened beverages is associated with obesity, and this association may be modified by a genetic predisposition to obesity. Objective: We examined the interactions between a molecular genetic predisposition to various aspects of obesity and the consumption of soft drinks, which are a major part of sugar-sweetened beverages, in relation to changes in adiposity measures. Design: A total of 4765 individuals were included in the study. On the basis of 50 obesity- Associated single nucleotide polymorphisms that are associated with body mass index (BMI), waist circumference (WC), or the waist- To-hip ratio adjusted for BMI (WHRBMI), the following 4 genetic predisposition scores (GRSs) were constructed: A complete genetic predisposition score including all 50 single nucleotide polymorphisms (GRSComplete), a genetic predisposition score including BMI- Associated single nucleotide polymorphisms (GRSBMI), a genetic predisposition score including waist circumference- Associated single nucleotide polymorphisms (GRSWC), and a genetic predisposition score including the waist- To-hip ratio adjusted for BMI- Associated single nucleotide polymorphisms (GRSWHR). Associations between soft drink intake and the annual change (D) in body weight (BW), WC, or waist circumference adjusted for BMI (WCBMI) and possible interactions with the GRSs were examined with the use of linear regression analyses and meta- Analyses. Results: For each soft drink serving per day, soft drink consumption was significantly associated with a higher DBWof 0.07 kg/y (95{\%} CI: 0.01, 0.13 kg/y; P = 0.020) but not with the DWC or DWCBMI. In analyses of the DBW, we showed an interaction only with the GRSWC (per risk allele for each soft drink serving per day: 20.06 kg/y; 95{\%} CI: 20.10, 20.02 kg/y; P = 0.006). In analyses of the DWC, we showed interactions only with the GRSBMI and GRSComplete [per risk allele for each soft drink serving per day: 0.05 cm/y (95{\%} CI: 0.02, 0.09 cm/y; P = 0.001) and 0.05 cm/y (95{\%} CI: 0.02, 0.07 cm/y; P = 0.001), respectively]. Nearly identical results were observed in analyses of the DWCBMI. Conclusions: A genetic predisposition to a high WC may attenuate the association between soft drink intake and BW gain. A genetic predisposition to high BMI as well as a genetic predisposition to high BMI, WC, and WHRBMI combined may strengthen the association between soft drink intake and WC gain. However, the public health impact may be limited. Am J Clin Nutr 2016;104:816-26. {\circledC} 2016 American Society for Nutrition.",
author = "Olsen, {Nanna J} and Lars {\"A}ngquist and Larsen, {Sofus C} and Allan Linneberg and Tea Skaaby and Husemoen, {Lise Lotte N} and Ulla Toft and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Torben Hansen and Oluf Pedersen and Kim Overvad and Ahluwalia, {Tarunveer Singh} and {I. A. S{\o}rensen}, Thorkild and Heitmann, {B. L.}",
note = "Export Date: 22 March 2017 CODEN: AJCNA",
year = "2016",
doi = "10.3945/ajcn.115.122820",
language = "English",
volume = "104",
pages = "816--826",
journal = "The American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "AMER SOC NUTRITION-ASN",
number = "3",

}

Olsen, NJ, Ängquist, L, Larsen, SC, Linneberg, A, Skaaby, T, Husemoen, LLN, Toft, U, Tjønneland, A, Halkjær, J, Hansen, T, Pedersen, O, Overvad, K, Ahluwalia, TS, I. A. Sørensen, T & Heitmann, BL 2016, 'Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference', American Journal of Clinical Nutrition, bind 104, nr. 3, s. 816-826. https://doi.org/10.3945/ajcn.115.122820

Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference. / Olsen, Nanna J; Ängquist, Lars; Larsen, Sofus C; Linneberg, Allan; Skaaby, Tea; Husemoen, Lise Lotte N; Toft, Ulla; Tjønneland, Anne ; Halkjær, Jytte; Hansen, Torben; Pedersen, Oluf; Overvad, Kim; Ahluwalia, Tarunveer Singh; I. A. Sørensen, Thorkild; Heitmann, B. L.

I: American Journal of Clinical Nutrition, Bind 104, Nr. 3, 2016, s. 816-826.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference

AU - Olsen, Nanna J

AU - Ängquist, Lars

AU - Larsen, Sofus C

AU - Linneberg, Allan

AU - Skaaby, Tea

AU - Husemoen, Lise Lotte N

AU - Toft, Ulla

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Overvad, Kim

AU - Ahluwalia, Tarunveer Singh

AU - I. A. Sørensen, Thorkild

AU - Heitmann, B. L.

N1 - Export Date: 22 March 2017 CODEN: AJCNA

PY - 2016

Y1 - 2016

N2 - Background: Intake of sugar-sweetened beverages is associated with obesity, and this association may be modified by a genetic predisposition to obesity. Objective: We examined the interactions between a molecular genetic predisposition to various aspects of obesity and the consumption of soft drinks, which are a major part of sugar-sweetened beverages, in relation to changes in adiposity measures. Design: A total of 4765 individuals were included in the study. On the basis of 50 obesity- Associated single nucleotide polymorphisms that are associated with body mass index (BMI), waist circumference (WC), or the waist- To-hip ratio adjusted for BMI (WHRBMI), the following 4 genetic predisposition scores (GRSs) were constructed: A complete genetic predisposition score including all 50 single nucleotide polymorphisms (GRSComplete), a genetic predisposition score including BMI- Associated single nucleotide polymorphisms (GRSBMI), a genetic predisposition score including waist circumference- Associated single nucleotide polymorphisms (GRSWC), and a genetic predisposition score including the waist- To-hip ratio adjusted for BMI- Associated single nucleotide polymorphisms (GRSWHR). Associations between soft drink intake and the annual change (D) in body weight (BW), WC, or waist circumference adjusted for BMI (WCBMI) and possible interactions with the GRSs were examined with the use of linear regression analyses and meta- Analyses. Results: For each soft drink serving per day, soft drink consumption was significantly associated with a higher DBWof 0.07 kg/y (95% CI: 0.01, 0.13 kg/y; P = 0.020) but not with the DWC or DWCBMI. In analyses of the DBW, we showed an interaction only with the GRSWC (per risk allele for each soft drink serving per day: 20.06 kg/y; 95% CI: 20.10, 20.02 kg/y; P = 0.006). In analyses of the DWC, we showed interactions only with the GRSBMI and GRSComplete [per risk allele for each soft drink serving per day: 0.05 cm/y (95% CI: 0.02, 0.09 cm/y; P = 0.001) and 0.05 cm/y (95% CI: 0.02, 0.07 cm/y; P = 0.001), respectively]. Nearly identical results were observed in analyses of the DWCBMI. Conclusions: A genetic predisposition to a high WC may attenuate the association between soft drink intake and BW gain. A genetic predisposition to high BMI as well as a genetic predisposition to high BMI, WC, and WHRBMI combined may strengthen the association between soft drink intake and WC gain. However, the public health impact may be limited. Am J Clin Nutr 2016;104:816-26. © 2016 American Society for Nutrition.

AB - Background: Intake of sugar-sweetened beverages is associated with obesity, and this association may be modified by a genetic predisposition to obesity. Objective: We examined the interactions between a molecular genetic predisposition to various aspects of obesity and the consumption of soft drinks, which are a major part of sugar-sweetened beverages, in relation to changes in adiposity measures. Design: A total of 4765 individuals were included in the study. On the basis of 50 obesity- Associated single nucleotide polymorphisms that are associated with body mass index (BMI), waist circumference (WC), or the waist- To-hip ratio adjusted for BMI (WHRBMI), the following 4 genetic predisposition scores (GRSs) were constructed: A complete genetic predisposition score including all 50 single nucleotide polymorphisms (GRSComplete), a genetic predisposition score including BMI- Associated single nucleotide polymorphisms (GRSBMI), a genetic predisposition score including waist circumference- Associated single nucleotide polymorphisms (GRSWC), and a genetic predisposition score including the waist- To-hip ratio adjusted for BMI- Associated single nucleotide polymorphisms (GRSWHR). Associations between soft drink intake and the annual change (D) in body weight (BW), WC, or waist circumference adjusted for BMI (WCBMI) and possible interactions with the GRSs were examined with the use of linear regression analyses and meta- Analyses. Results: For each soft drink serving per day, soft drink consumption was significantly associated with a higher DBWof 0.07 kg/y (95% CI: 0.01, 0.13 kg/y; P = 0.020) but not with the DWC or DWCBMI. In analyses of the DBW, we showed an interaction only with the GRSWC (per risk allele for each soft drink serving per day: 20.06 kg/y; 95% CI: 20.10, 20.02 kg/y; P = 0.006). In analyses of the DWC, we showed interactions only with the GRSBMI and GRSComplete [per risk allele for each soft drink serving per day: 0.05 cm/y (95% CI: 0.02, 0.09 cm/y; P = 0.001) and 0.05 cm/y (95% CI: 0.02, 0.07 cm/y; P = 0.001), respectively]. Nearly identical results were observed in analyses of the DWCBMI. Conclusions: A genetic predisposition to a high WC may attenuate the association between soft drink intake and BW gain. A genetic predisposition to high BMI as well as a genetic predisposition to high BMI, WC, and WHRBMI combined may strengthen the association between soft drink intake and WC gain. However, the public health impact may be limited. Am J Clin Nutr 2016;104:816-26. © 2016 American Society for Nutrition.

U2 - 10.3945/ajcn.115.122820

DO - 10.3945/ajcn.115.122820

M3 - Journal article

C2 - 27465380

VL - 104

SP - 816

EP - 826

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -