Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen, Ulla Vogel, Jane Hvarregaard Christensen, Rikke Hansen, Erik Håkan Richard Wallin, Kim Overvad, Anne Tjønneland, Janne Tolstrup

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.
OriginalsprogEngelsk
TidsskriftCancer Letters
Vol/bind295
Udgave nummer2
Sider (fra-til)191-7
Antal sider7
ISSN0304-3835
DOI
StatusUdgivet - 28. sep. 2010

Fingeraftryk

Ethanol
Alcohols
Acetaldehyde
Alleles
Diet
Health
Neoplasms

Citer dette

Benzon Larsen, Signe ; Vogel, Ulla ; Christensen, Jane Hvarregaard ; Hansen, Rikke ; Wallin, Erik Håkan Richard ; Overvad, Kim ; Tjønneland, Anne ; Tolstrup, Janne. / Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. I: Cancer Letters. 2010 ; Bind 295, Nr. 2. s. 191-7.
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title = "Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer",
abstract = "Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14{\%} (95{\%} CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.",
keywords = "Alcohol Dehydrogenase, Alcohol Drinking, Breast Neoplasms, Ethanol, Female, Humans, Middle Aged, Polymorphism, Genetic, Risk Factors",
author = "{Benzon Larsen}, Signe and Ulla Vogel and Christensen, {Jane Hvarregaard} and Rikke Hansen and Wallin, {Erik H{\aa}kan Richard} and Kim Overvad and Anne Tj{\o}nneland and Janne Tolstrup",
note = "2010 Elsevier Ireland Ltd. All rights reserved.",
year = "2010",
month = "9",
day = "28",
doi = "10.1016/j.canlet.2010.02.023",
language = "English",
volume = "295",
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Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. / Benzon Larsen, Signe; Vogel, Ulla; Christensen, Jane Hvarregaard; Hansen, Rikke; Wallin, Erik Håkan Richard; Overvad, Kim; Tjønneland, Anne; Tolstrup, Janne.

I: Cancer Letters, Bind 295, Nr. 2, 28.09.2010, s. 191-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

AU - Benzon Larsen, Signe

AU - Vogel, Ulla

AU - Christensen, Jane Hvarregaard

AU - Hansen, Rikke

AU - Wallin, Erik Håkan Richard

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Tolstrup, Janne

N1 - 2010 Elsevier Ireland Ltd. All rights reserved.

PY - 2010/9/28

Y1 - 2010/9/28

N2 - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

AB - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

KW - Alcohol Dehydrogenase

KW - Alcohol Drinking

KW - Breast Neoplasms

KW - Ethanol

KW - Female

KW - Humans

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Risk Factors

U2 - 10.1016/j.canlet.2010.02.023

DO - 10.1016/j.canlet.2010.02.023

M3 - Journal article

C2 - 20350778

VL - 295

SP - 191

EP - 197

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -