Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika

Jeanette Krogh Petersen, David Scheie, Henning Boldt, Benedicte Parm Ulhøi, Marianne Schmidt Ettrup, Bjarne Winther Kristensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A considerable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute “integrated diagnoses”. The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.
Bidragets oversatte titelIntegrated diagnostics of brain tumours based on histological and molecular features
OriginalsprogDansk
ArtikelnummerV07180509
TidsskriftUgeskrift for Laeger
Vol/bind181
Udgave nummer21
ISSN0041-5782
StatusUdgivet - 2019

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