Intact primary mitochondrial function in myotubes established from women with PCOS

Mette Brandt Eriksen, Ariane Denise Minet, Dorte Glintborg, Michael Gaster

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Polycystic ovary syndrome (PCOS) affects 5-8% of fertile women and is often accompanied by insulin resistance, leading to increased risk of developing type 2 diabetes. Skeletal muscle from insulin-resistant PCOS subjects display reduced expression of nuclear encoded genes involved in mitochondrial oxidative metabolism.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Endocrinology and Metabolism
Vol/bind96
Udgave nummer8
Sider (fra-til)E1298-302
ISSN0021-972X
DOI
StatusUdgivet - 2011

Fingeraftryk

Polycystic Ovary Syndrome
Primary Ovarian Insufficiency
Type 2 Diabetes Mellitus
Insulin Resistance
Skeletal Muscle
Insulin

Citer dette

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title = "Intact primary mitochondrial function in myotubes established from women with PCOS",
abstract = "Polycystic ovary syndrome (PCOS) affects 5-8{\%} of fertile women and is often accompanied by insulin resistance, leading to increased risk of developing type 2 diabetes. Skeletal muscle from insulin-resistant PCOS subjects display reduced expression of nuclear encoded genes involved in mitochondrial oxidative metabolism.",
keywords = "Adaptation, Physiological, Adenosine Triphosphate, Adult, Cells, Cultured, Female, Glucose Clamp Technique, Humans, Hyperinsulinism, Insulin Resistance, Mitochondria, Mitochondrial Diseases, Muscle Fibers, Skeletal, Oxidative Phosphorylation, Polycystic Ovary Syndrome",
author = "Eriksen, {Mette Brandt} and Minet, {Ariane Denise} and Dorte Glintborg and Michael Gaster",
year = "2011",
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volume = "96",
pages = "E1298--302",
journal = "Journal of Clinical Endocrinology and Metabolism",
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Intact primary mitochondrial function in myotubes established from women with PCOS. / Eriksen, Mette Brandt; Minet, Ariane Denise; Glintborg, Dorte; Gaster, Michael.

I: Journal of Clinical Endocrinology and Metabolism, Bind 96, Nr. 8, 2011, s. E1298-302.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Intact primary mitochondrial function in myotubes established from women with PCOS

AU - Eriksen, Mette Brandt

AU - Minet, Ariane Denise

AU - Glintborg, Dorte

AU - Gaster, Michael

PY - 2011

Y1 - 2011

N2 - Polycystic ovary syndrome (PCOS) affects 5-8% of fertile women and is often accompanied by insulin resistance, leading to increased risk of developing type 2 diabetes. Skeletal muscle from insulin-resistant PCOS subjects display reduced expression of nuclear encoded genes involved in mitochondrial oxidative metabolism.

AB - Polycystic ovary syndrome (PCOS) affects 5-8% of fertile women and is often accompanied by insulin resistance, leading to increased risk of developing type 2 diabetes. Skeletal muscle from insulin-resistant PCOS subjects display reduced expression of nuclear encoded genes involved in mitochondrial oxidative metabolism.

KW - Adaptation, Physiological

KW - Adenosine Triphosphate

KW - Adult

KW - Cells, Cultured

KW - Female

KW - Glucose Clamp Technique

KW - Humans

KW - Hyperinsulinism

KW - Insulin Resistance

KW - Mitochondria

KW - Mitochondrial Diseases

KW - Muscle Fibers, Skeletal

KW - Oxidative Phosphorylation

KW - Polycystic Ovary Syndrome

U2 - 10.1210/jc.2011-0278

DO - 10.1210/jc.2011-0278

M3 - Journal article

VL - 96

SP - E1298-302

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 8

ER -