@article{ab2ef530fa0711deaefb000ea68e967b,
title = "Insulin and the insulin-like growth factors I and II are mitogenic to cultured rat sciatic nerve segments and stimulate [3H]thymidine incorporation through their respective receptors",
abstract = "The factors that control proliferation of Schwann cells during peripheral nerve regeneration are not yet known. In this study we investigated the effects of insulin, insulin-like growth factor I and II (IGF-I and IGF-II), IGF-I analogues, and factors that interfere with their respective receptors, on [3H]thymidine incorporation into cultured nerve segments from the rat sciatic nerve. Segments cultured in nM (0.1-1.7 nM) concentrations of insulin, truncated IGF-I (tIGF-I), long R3IGF-I, or IGF-II exhibited an increase in [3H]thymidine incorporation compared with control segments. IGF-II was most potent. JB1, an IGF-I antagonist, counteracted the effects of tIGF-I and insulin. The results suggest that non-neuronal cells in the nerve segment, probably Schwann cells, possess distinct receptors for insulin, IGF-I, and IGF-II and that these receptors may be involved in the control of Schwann cell proliferation during peripheral nerve regeneration.",
keywords = "Animals, Cells, Cultured, Female, Hypoglycemic Agents, Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Ligands, Mannosephosphates, Mitogens, Neurons, Rats, Rats, Sprague-Dawley, Receptor, IGF Type 1, Receptor, IGF Type 2, Receptor, Insulin, Sciatic Nerve, Stimulation, Chemical, Thymidine",
author = "Svenningsen, {{\AA}sa Fex} and M Kanje",
year = "1996",
language = "English",
volume = "18",
pages = "68--72",
journal = "Glia",
issn = "0894-1491",
publisher = "JohnWiley & Sons, Inc.",
number = "1",
}