Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering

Wiebke Reichstein, Levke Sommer, Salih Veziroglu, Selin Sayin, Stefan Schröder, Yogendra Kumar Mishra, Eyüp İlker Saygili, Fatih Karayürek, Yahya Açil, Jörg Wiltfang, Aydin Gülses*, Franz Faupel, Oral Cenk Aktas

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Abstrakt

The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP–PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.

OriginalsprogEngelsk
Artikelnummer186
TidsskriftPolymers
Vol/bind13
Udgave nummer2
Antal sider11
ISSN2073-4360
DOI
StatusUdgivet - 2. jan. 2021

Bibliografisk note

Funding Information:
Funding: This research was funded by the German Research Foundation (DFG) within the frame of Research Training Group “Materials4Brain” (RTG2154).

Publisher Copyright:
© 2021 by the authors. Li-censee MDPI, Basel, Switzerland.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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