Influence of hyperthermia on the phosphorylation of ribosomal protein S6 from human skin fibroblasts and meningioma cells

W W Richter, K D Zang, O G Issinger

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Resumé

Udgivelsesdato: 1983-Mar-21
OriginalsprogEngelsk
TidsskriftFEBS Letters
Vol/bind153
Udgave nummer2
Sider (fra-til)262-266
Antal sider4
ISSN0014-5793
StatusUdgivet - 1983

Fingeraftryk

Ribosomal Protein S6
Phosphorylation
Meningioma
Fibroblasts
Skin
S 6
Cell culture
Tumors
Cells
Proteins
Neoplasms

Citer dette

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title = "Influence of hyperthermia on the phosphorylation of ribosomal protein S6 from human skin fibroblasts and meningioma cells",
abstract = "Skin fibroblasts and meningioma cells, derived from primary cultures of the same patients have been used to study the influence of hyperthermia on (i) cell morphology and (ii) phosphorylation pattern of ribosomal and ribosome-associated proteins. Incubation of tumour cells and fibroblasts up to 7 h at 42 degrees C did not significantly change the cell morphology as compared to control cells kept at 37 degrees C. At 42 degrees C ribosomal protein S6 is shifted cathodically indicating a loss of negative charge, however no quantitative dephosphorylation of S6 was observed. Meningioma cells and fibroblasts did not differ significantly with respect to S6 phosphorylation.",
keywords = "Cells, Cultured, Fibroblasts, Hot Temperature, Humans, Kinetics, Meningioma, Phosphates, Phosphorus Radioisotopes, Phosphorylation, Ribosomal Protein S6, Ribosomal Proteins, Skin",
author = "Richter, {W W} and Zang, {K D} and Issinger, {O G}",
year = "1983",
language = "English",
volume = "153",
pages = "262--266",
journal = "F E B S Letters",
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Influence of hyperthermia on the phosphorylation of ribosomal protein S6 from human skin fibroblasts and meningioma cells. / Richter, W W; Zang, K D; Issinger, O G.

I: FEBS Letters, Bind 153, Nr. 2, 1983, s. 262-266.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Influence of hyperthermia on the phosphorylation of ribosomal protein S6 from human skin fibroblasts and meningioma cells

AU - Richter, W W

AU - Zang, K D

AU - Issinger, O G

PY - 1983

Y1 - 1983

N2 - Skin fibroblasts and meningioma cells, derived from primary cultures of the same patients have been used to study the influence of hyperthermia on (i) cell morphology and (ii) phosphorylation pattern of ribosomal and ribosome-associated proteins. Incubation of tumour cells and fibroblasts up to 7 h at 42 degrees C did not significantly change the cell morphology as compared to control cells kept at 37 degrees C. At 42 degrees C ribosomal protein S6 is shifted cathodically indicating a loss of negative charge, however no quantitative dephosphorylation of S6 was observed. Meningioma cells and fibroblasts did not differ significantly with respect to S6 phosphorylation.

AB - Skin fibroblasts and meningioma cells, derived from primary cultures of the same patients have been used to study the influence of hyperthermia on (i) cell morphology and (ii) phosphorylation pattern of ribosomal and ribosome-associated proteins. Incubation of tumour cells and fibroblasts up to 7 h at 42 degrees C did not significantly change the cell morphology as compared to control cells kept at 37 degrees C. At 42 degrees C ribosomal protein S6 is shifted cathodically indicating a loss of negative charge, however no quantitative dephosphorylation of S6 was observed. Meningioma cells and fibroblasts did not differ significantly with respect to S6 phosphorylation.

KW - Cells, Cultured

KW - Fibroblasts

KW - Hot Temperature

KW - Humans

KW - Kinetics

KW - Meningioma

KW - Phosphates

KW - Phosphorus Radioisotopes

KW - Phosphorylation

KW - Ribosomal Protein S6

KW - Ribosomal Proteins

KW - Skin

M3 - Journal article

VL - 153

SP - 262

EP - 266

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 2

ER -