Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons

Amanda Mocroft, Jens D. Lundgren, Juergen K. Rockstroh, Inka Aho, Gilles Wandeler, Lars Nielsen, Simon Edwards, Jean Paul Viard, Karine Lacombe, Gerd Fätkenheuer, Giovanni Guaraldi, Montserrat Laguno, Josep Llibre, Hila Elinav, Leo Flamholc, Martin Gisinger, Dzmitry Paduta, Irina Khromova, David Jilich, Blazej RozplochowskiCristiana Oprea, Lars Peters, EuroSIDA Study, Line Dahlerup Rasmussen (Medlem af forfattergruppering)

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Background. The role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear. Methods. Poisson regression was used to compare incidence rates of DM (blood glucose >11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (anti-HCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment). Results. A total of 16 099 persons were included; at baseline 10 091 (62.7%) were HCV-Ab-negative, 722 (4.5%) were spontaneous clearers, 3614 (22.4%) were chronically infected, 912 (5.7%) had been successfully treated, and 760 (4.7%) were HCV-RNApositive after treatment. During 136 084 person-years of follow-up (PYFU; median [interquartile range], 6.9 [3.6-13.2]), 1108 (6.9%) developed DM (crude incidence rate, 8.1/1000 PYFU; 95% CI, 7.7-8.6). After adjustment, there was no difference between the 5 HCV strata in incidence of DM (global P = .33). Hypertension (22.2%; 95% CI, 17.5%-26.2%) and body mass index >25 (22.0%; 95% CI, 10.4%-29.7%) had the largest population-attributable fractions for DM. Conclusions. HCV coinfection and HCV cure were not associated with DM in this large study. The biggest modifiable risk factors were hypertension and obesity, and continued efforts to manage such comorbidities should be prioritized.

TidsskriftOpen Forum Infectious Diseases
Udgave nummer12
Sider (fra-til)1-10
StatusUdgivet - 1. dec. 2020

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