Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis

Keld-Erik Byg; Zsolt Illés; Tobias Sejbæk; Kate Lykke Lambertsen; Torkell Juulsgaard Ellingsen; Helle Hvilsted Nielsen

doi:10.1016/j.jneuroim.2022.577849

Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis

Keld-Erik Byg, Zsolt Illés, Tobias Sejbæk, Kate Lykke Lambertsen, Torkell Juulsgaard Ellingsen, Helle Hvilsted Nielsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Downloads (Pure)

Abstrakt

Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC). Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, TNFβ, IL-2, IL-6, IL-10, IL-12B, IL-15, IL-16, CCL2, CCL3, CCL4, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, TNFR2, VEGF-A, PIGF, SAA, VCAM1, and ICAM1. In plasma, 12 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, CCL2, CCL3, CCL4, CCL17, CXCL10, VEGFR1, PIGF, SAA, VCAM1, and ICAM1. Conclusion: NS patients have profoundly elevated cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in CSF and plasma.

Originalsprog	Engelsk
Artikelnummer	577849
Tidsskrift	Journal of Neuroimmunology
Vol/bind	367
ISSN	0165-5728
DOI	https://doi.org/10.1016/j.jneuroim.2022.577849
Status	Udgivet - 15. jun. 2022

Dokumenter og links

10.1016/j.jneuroim.2022.577849Licens: CC BY

Open Access VersionForlagets udgivne version, 836 KBLicens: CC BY

1 Ph.d.-afhandling

Neurosarcoidosis: Inflammation, Damage, and Treatment response
Byg, K-E., 30. sep. 2022, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 123 s.
Publikation: Afhandling › Ph.d.-afhandling

Åben adgang
Fil
4 Downloads (Pure)

Citationsformater

@article{d1b67c30ffc74e0e9cc37045f829e2ba,

title = "Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis",

abstract = "Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC). Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, TNFβ, IL-2, IL-6, IL-10, IL-12B, IL-15, IL-16, CCL2, CCL3, CCL4, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, TNFR2, VEGF-A, PIGF, SAA, VCAM1, and ICAM1. In plasma, 12 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, CCL2, CCL3, CCL4, CCL17, CXCL10, VEGFR1, PIGF, SAA, VCAM1, and ICAM1. Conclusion: NS patients have profoundly elevated cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in CSF and plasma.",

keywords = "Biomarkers, Chemokines, Cytokines, Neurosarcoidosis, Vascular angiogenesis, Vascular injury",

author = "Keld-Erik Byg and Zsolt Ill{\'e}s and Tobias Sejb{\ae}k and Lambertsen, {Kate Lykke} and Ellingsen, {Torkell Juulsgaard} and Nielsen, {Helle Hvilsted}",

year = "2022",

month = jun,

day = "15",

doi = "10.1016/j.jneuroim.2022.577849",

language = "English",

volume = "367",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis

AU - Byg, Keld-Erik

AU - Illés, Zsolt

AU - Sejbæk, Tobias

AU - Lambertsen, Kate Lykke

AU - Ellingsen, Torkell Juulsgaard

AU - Nielsen, Helle Hvilsted

PY - 2022/6/15

Y1 - 2022/6/15

N2 - Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC). Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, TNFβ, IL-2, IL-6, IL-10, IL-12B, IL-15, IL-16, CCL2, CCL3, CCL4, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, TNFR2, VEGF-A, PIGF, SAA, VCAM1, and ICAM1. In plasma, 12 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, CCL2, CCL3, CCL4, CCL17, CXCL10, VEGFR1, PIGF, SAA, VCAM1, and ICAM1. Conclusion: NS patients have profoundly elevated cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in CSF and plasma.

AB - Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC). Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, TNFβ, IL-2, IL-6, IL-10, IL-12B, IL-15, IL-16, CCL2, CCL3, CCL4, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, TNFR2, VEGF-A, PIGF, SAA, VCAM1, and ICAM1. In plasma, 12 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, CCL2, CCL3, CCL4, CCL17, CXCL10, VEGFR1, PIGF, SAA, VCAM1, and ICAM1. Conclusion: NS patients have profoundly elevated cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in CSF and plasma.

KW - Biomarkers

KW - Chemokines

KW - Cytokines

KW - Neurosarcoidosis

KW - Vascular angiogenesis

KW - Vascular injury

U2 - 10.1016/j.jneuroim.2022.577849

DO - 10.1016/j.jneuroim.2022.577849

M3 - Journal article

C2 - 35366560

VL - 367

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

M1 - 577849

ER -

Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis

Abstrakt

Dokumenter og links

Fingeraftryk

Relaterede publikationer

Neurosarcoidosis: Inflammation, Damage, and Treatment response

Citationsformater