Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

Anna Bugge; Bianca El-Naaman; Robert G McMurray; Karsten Froberg; Claus Henrik Nielsen; Klaus Müller; Lars Bo Andersen

doi:10.1159/000345546

Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

Anna Bugge, Bianca El-Naaman, Robert G McMurray, Karsten Froberg, Claus Henrik Nielsen, Klaus Müller, Lars Bo Andersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Aims: To evaluate the associations between inflammatory markers and clustering of cardiovascular disease (CVD) risk factors, and to examine how inflammatory markers and CVD risk are related to fatness and cardiorespiratory fitness (VO(2peak)) in adolescents. Methods: Body mass and height, skinfolds and blood pressure of 413 adolescents (mean age 13.4 ± 0.3 years) were measured. Circulating fasting levels of glucose, insulin, lipids, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)α, soluble TNF receptor-1 (sTNFR1), interleukin (IL)-6 and IL-1 receptor antagonist (IL-1Ra) were measured. VO(2peak) was measured in progressive tests to exhaustion. CVD risk was expressed as a clustered z-score, summing standardized values of individual risk factors. Results: The clustered z-score was negatively associated with adiponectin and positively associated with CRP, IL-6 and TNFα (all p values

Originalsprog	Engelsk
Tidsskrift	Hormone Research in Paediatrics
Vol/bind	78
Udgave nummer	5-6
Sider (fra-til)	288-296
ISSN	1663-2818
DOI	https://doi.org/10.1159/000345546
Status	Udgivet - dec. 2012

Dokumenter og links

10.1159/000345546

Citationsformater

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title = "Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents",

abstract = "Aims: To evaluate the associations between inflammatory markers and clustering of cardiovascular disease (CVD) risk factors, and to examine how inflammatory markers and CVD risk are related to fatness and cardiorespiratory fitness (VO(2peak)) in adolescents. Methods: Body mass and height, skinfolds and blood pressure of 413 adolescents (mean age 13.4 ± 0.3 years) were measured. Circulating fasting levels of glucose, insulin, lipids, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)α, soluble TNF receptor-1 (sTNFR1), interleukin (IL)-6 and IL-1 receptor antagonist (IL-1Ra) were measured. VO(2peak) was measured in progressive tests to exhaustion. CVD risk was expressed as a clustered z-score, summing standardized values of individual risk factors. Results: The clustered z-score was negatively associated with adiponectin and positively associated with CRP, IL-6 and TNFα (all p values ",

author = "Anna Bugge and Bianca El-Naaman and McMurray, {Robert G} and Karsten Froberg and Nielsen, {Claus Henrik} and Klaus M{\"u}ller and Andersen, {Lars Bo}",

note = "Copyright {\textcopyright} 2012 S. Karger AG, Basel.",

year = "2012",

month = dec,

doi = "10.1159/000345546",

language = "English",

volume = "78",

pages = "288--296 ",

journal = "Hormone Research in Paediatrics",

issn = "1663-2818",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

AU - Bugge, Anna

AU - El-Naaman, Bianca

AU - McMurray, Robert G

AU - Froberg, Karsten

AU - Nielsen, Claus Henrik

AU - Müller, Klaus

AU - Andersen, Lars Bo

PY - 2012/12

Y1 - 2012/12

N2 - Aims: To evaluate the associations between inflammatory markers and clustering of cardiovascular disease (CVD) risk factors, and to examine how inflammatory markers and CVD risk are related to fatness and cardiorespiratory fitness (VO(2peak)) in adolescents. Methods: Body mass and height, skinfolds and blood pressure of 413 adolescents (mean age 13.4 ± 0.3 years) were measured. Circulating fasting levels of glucose, insulin, lipids, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)α, soluble TNF receptor-1 (sTNFR1), interleukin (IL)-6 and IL-1 receptor antagonist (IL-1Ra) were measured. VO(2peak) was measured in progressive tests to exhaustion. CVD risk was expressed as a clustered z-score, summing standardized values of individual risk factors. Results: The clustered z-score was negatively associated with adiponectin and positively associated with CRP, IL-6 and TNFα (all p values

AB - Aims: To evaluate the associations between inflammatory markers and clustering of cardiovascular disease (CVD) risk factors, and to examine how inflammatory markers and CVD risk are related to fatness and cardiorespiratory fitness (VO(2peak)) in adolescents. Methods: Body mass and height, skinfolds and blood pressure of 413 adolescents (mean age 13.4 ± 0.3 years) were measured. Circulating fasting levels of glucose, insulin, lipids, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)α, soluble TNF receptor-1 (sTNFR1), interleukin (IL)-6 and IL-1 receptor antagonist (IL-1Ra) were measured. VO(2peak) was measured in progressive tests to exhaustion. CVD risk was expressed as a clustered z-score, summing standardized values of individual risk factors. Results: The clustered z-score was negatively associated with adiponectin and positively associated with CRP, IL-6 and TNFα (all p values

U2 - 10.1159/000345546

DO - 10.1159/000345546

M3 - Journal article

C2 - 23235468

SN - 1663-2818

VL - 78

SP - 288

EP - 296

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

IS - 5-6

ER -

Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

Abstract

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