Inflammation, thrombosis, and atherosclerosis

results of the Glostrup study

M.P.M. de Maat, E.M. Bladbjerg, T. Drivsholm, K.B. Johnsen, L. Møller, J. Jespersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
Udgivelsesdato: 2003-May
OriginalsprogEngelsk
TidsskriftJournal of Thrombosis and Haemostasis
Vol/bind1
Udgave nummer5
Sider (fra-til)950-957
ISSN1538-7933
DOI
StatusUdgivet - 2003

Fingeraftryk

Hemostatics
Plasminogen Activator Inhibitor 1
Factor VIIa
Carotid Stenosis
Tissue Plasminogen Activator
Epidemiologic Studies
DNA
Population

Citer dette

de Maat, M.P.M. ; Bladbjerg, E.M. ; Drivsholm, T. ; Johnsen, K.B. ; Møller, L. ; Jespersen, J. / Inflammation, thrombosis, and atherosclerosis : results of the Glostrup study. I: Journal of Thrombosis and Haemostasis. 2003 ; Bind 1, Nr. 5. s. 950-957.
@article{087ed7e0ba9b11dc9626000ea68e967b,
title = "Inflammation, thrombosis, and atherosclerosis: results of the Glostrup study",
abstract = "Inflammation and thrombosis are important mechanisms in cardiovascular disease, as illustrated by the consistent association between inflammatory and hemostatic variables and the risk of cardiovascular events in epidemiological studies. However, the relationship between plasma concentrations of inflammatory and hemostatic markers and the severity of atherosclerosis is not yet well studied. We have evaluated 325 men and 370 women of 60 years, participating in the Danish Glostrup study. We diagnosed atherosclerosis by ultrasonographic measurement of intima-media thickness (IMT) of the right carotid artery and the assessment of plaque occurrence. Plasma samples were analyzed for the concentration of C-reactive protein (CRP), fibrinogen, d-dimer, plasminogen activator inhibitor type-1 (PAI-1) antigen and activity, tissue-type plasminogen activator (t-PA) antigen and activity, factor VII (FVII) antigen, FVII coagulant activity (FVII:C) and activated FVII (FVIIa). DNA variations were determined for fibrinogen, PAI-1, t-PA, FVII, factor XIII and methylene tetrahydrofolate reductase (MTHFR). Subjects with high IMT (upper 10{\%} of distribution, n = 63) had higher CRP levels [2.2 mg L-1 (SE 0.3)] than subjects with IMT in the lowest tertile (n = 217) [1.7 mg L-1 (SE 0.1), P = 0.04], whereas there was no association between the hemostatic variables and IMT. There was an association between fibrinogen and d-dimer concentrations and number of plaques (P < 0.01), whereas there were no associations between CRP and the other hemostatic variables and the number of plaques. Genetic variation in the t-PA and MTHFR gene was associated with IMT. In conclusion, in the Glostrup population study, thrombosis and inflammation are associated with the severity of atherosclerosis, as reflected by IMT and plaque occurrence.",
author = "{de Maat}, M.P.M. and E.M. Bladbjerg and T. Drivsholm and K.B. Johnsen and L. M{\o}ller and J. Jespersen",
year = "2003",
doi = "10.1046/j.1538-7836.2003.00213.x",
language = "English",
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pages = "950--957",
journal = "Journal of Thrombosis and Haemostasis",
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Inflammation, thrombosis, and atherosclerosis : results of the Glostrup study. / de Maat, M.P.M.; Bladbjerg, E.M.; Drivsholm, T.; Johnsen, K.B.; Møller, L.; Jespersen, J.

I: Journal of Thrombosis and Haemostasis, Bind 1, Nr. 5, 2003, s. 950-957.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Inflammation, thrombosis, and atherosclerosis

T2 - results of the Glostrup study

AU - de Maat, M.P.M.

AU - Bladbjerg, E.M.

AU - Drivsholm, T.

AU - Johnsen, K.B.

AU - Møller, L.

AU - Jespersen, J.

PY - 2003

Y1 - 2003

N2 - Inflammation and thrombosis are important mechanisms in cardiovascular disease, as illustrated by the consistent association between inflammatory and hemostatic variables and the risk of cardiovascular events in epidemiological studies. However, the relationship between plasma concentrations of inflammatory and hemostatic markers and the severity of atherosclerosis is not yet well studied. We have evaluated 325 men and 370 women of 60 years, participating in the Danish Glostrup study. We diagnosed atherosclerosis by ultrasonographic measurement of intima-media thickness (IMT) of the right carotid artery and the assessment of plaque occurrence. Plasma samples were analyzed for the concentration of C-reactive protein (CRP), fibrinogen, d-dimer, plasminogen activator inhibitor type-1 (PAI-1) antigen and activity, tissue-type plasminogen activator (t-PA) antigen and activity, factor VII (FVII) antigen, FVII coagulant activity (FVII:C) and activated FVII (FVIIa). DNA variations were determined for fibrinogen, PAI-1, t-PA, FVII, factor XIII and methylene tetrahydrofolate reductase (MTHFR). Subjects with high IMT (upper 10% of distribution, n = 63) had higher CRP levels [2.2 mg L-1 (SE 0.3)] than subjects with IMT in the lowest tertile (n = 217) [1.7 mg L-1 (SE 0.1), P = 0.04], whereas there was no association between the hemostatic variables and IMT. There was an association between fibrinogen and d-dimer concentrations and number of plaques (P < 0.01), whereas there were no associations between CRP and the other hemostatic variables and the number of plaques. Genetic variation in the t-PA and MTHFR gene was associated with IMT. In conclusion, in the Glostrup population study, thrombosis and inflammation are associated with the severity of atherosclerosis, as reflected by IMT and plaque occurrence.

AB - Inflammation and thrombosis are important mechanisms in cardiovascular disease, as illustrated by the consistent association between inflammatory and hemostatic variables and the risk of cardiovascular events in epidemiological studies. However, the relationship between plasma concentrations of inflammatory and hemostatic markers and the severity of atherosclerosis is not yet well studied. We have evaluated 325 men and 370 women of 60 years, participating in the Danish Glostrup study. We diagnosed atherosclerosis by ultrasonographic measurement of intima-media thickness (IMT) of the right carotid artery and the assessment of plaque occurrence. Plasma samples were analyzed for the concentration of C-reactive protein (CRP), fibrinogen, d-dimer, plasminogen activator inhibitor type-1 (PAI-1) antigen and activity, tissue-type plasminogen activator (t-PA) antigen and activity, factor VII (FVII) antigen, FVII coagulant activity (FVII:C) and activated FVII (FVIIa). DNA variations were determined for fibrinogen, PAI-1, t-PA, FVII, factor XIII and methylene tetrahydrofolate reductase (MTHFR). Subjects with high IMT (upper 10% of distribution, n = 63) had higher CRP levels [2.2 mg L-1 (SE 0.3)] than subjects with IMT in the lowest tertile (n = 217) [1.7 mg L-1 (SE 0.1), P = 0.04], whereas there was no association between the hemostatic variables and IMT. There was an association between fibrinogen and d-dimer concentrations and number of plaques (P < 0.01), whereas there were no associations between CRP and the other hemostatic variables and the number of plaques. Genetic variation in the t-PA and MTHFR gene was associated with IMT. In conclusion, in the Glostrup population study, thrombosis and inflammation are associated with the severity of atherosclerosis, as reflected by IMT and plaque occurrence.

U2 - 10.1046/j.1538-7836.2003.00213.x

DO - 10.1046/j.1538-7836.2003.00213.x

M3 - Journal article

VL - 1

SP - 950

EP - 957

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 5

ER -