Infant Respiratory Tract Infections or Wheeze and Maternal Vitamin D in Pregnancy

A Systematic Review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Respiratory tract infections (RTIs) are a common cause of morbidity and mortality in young children and can be associated with wheeze. Vitamin D can have a protective role against RTI.

MATERIALS AND METHODS: A systematic search of Pubmed, Embase and the Cochrane library was performed. Titles and abstracts were evaluated and selected articles were reviewed by two authors. We included randomized controlled trials (RCTs) investigating the effect of vitamin D supplementation during pregnancy on RTIs or wheeze in children of 5 years of age or younger. Observational studies on the association between serum 25-hydroxyvitamin D (25OHD) during pregnancy, or at birth, and RTIs and/or wheeze were included. The protocol was registered on PROSPERO (Registration No. CRD42015019183).

RESULTS: Of four RCTs, one showed a protective effect of a high daily dose (2,000IU) of vitamin D during pregnancy on offspring RTI doctor visits (p=0.004; the RCT also included 800IU/day supplement to the infants until six months). Meta-analysis of three RCTs showed a reduced relative risk (RR) for offspring wheeze when mothers were supplemented with vitamin D during pregnancy (RR=0.81 [95% CI 0.68-0.97], p=0.025). In three of four strong quality, and five of ten moderate quality observational studies, an inverse association between pregnancy and cord 25OHD and subsequent wheeze and/or RTI was seen.

CONCLUSION: Growing evidence support a preventive role of vitamin D during pregnancy on offspring wheeze and/or RTI. Future intervention studies may need to exceed current recommendations of vitamin D supplementation during pregnancy to show benefit against childhood wheeze or infections.

OriginalsprogEngelsk
TidsskriftPediatric Infectious Disease Journal
Vol/bind36
Udgave nummer4
Sider (fra-til)384-391
ISSN0891-3668
DOI
StatusUdgivet - 2017

Fingeraftryk

Mothers
Randomized Controlled Trials
PubMed
Libraries
Meta-Analysis
Serum

Citer dette

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title = "Infant Respiratory Tract Infections or Wheeze and Maternal Vitamin D in Pregnancy: A Systematic Review",
abstract = "Respiratory tract infections (RTIs) are a common cause of morbidity and mortality in young children and can be associated with wheeze. Vitamin D can have a protective role against RTI.MATERIALS AND METHODS: A systematic search of Pubmed, Embase and the Cochrane library was performed. Titles and abstracts were evaluated and selected articles were reviewed by two authors. We included randomized controlled trials (RCTs) investigating the effect of vitamin D supplementation during pregnancy on RTIs or wheeze in children of 5 years of age or younger. Observational studies on the association between serum 25-hydroxyvitamin D (25OHD) during pregnancy, or at birth, and RTIs and/or wheeze were included. The protocol was registered on PROSPERO (Registration No. CRD42015019183).RESULTS: Of four RCTs, one showed a protective effect of a high daily dose (2,000IU) of vitamin D during pregnancy on offspring RTI doctor visits (p=0.004; the RCT also included 800IU/day supplement to the infants until six months). Meta-analysis of three RCTs showed a reduced relative risk (RR) for offspring wheeze when mothers were supplemented with vitamin D during pregnancy (RR=0.81 [95{\%} CI 0.68-0.97], p=0.025). In three of four strong quality, and five of ten moderate quality observational studies, an inverse association between pregnancy and cord 25OHD and subsequent wheeze and/or RTI was seen.CONCLUSION: Growing evidence support a preventive role of vitamin D during pregnancy on offspring wheeze and/or RTI. Future intervention studies may need to exceed current recommendations of vitamin D supplementation during pregnancy to show benefit against childhood wheeze or infections.",
author = "Nikolas Christensen and Jens S{\o}ndergaard and Niels Fisker and Christensen, {Henrik Thybo}",
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T1 - Infant Respiratory Tract Infections or Wheeze and Maternal Vitamin D in Pregnancy

T2 - A Systematic Review

AU - Christensen, Nikolas

AU - Søndergaard, Jens

AU - Fisker, Niels

AU - Christensen, Henrik Thybo

PY - 2017

Y1 - 2017

N2 - Respiratory tract infections (RTIs) are a common cause of morbidity and mortality in young children and can be associated with wheeze. Vitamin D can have a protective role against RTI.MATERIALS AND METHODS: A systematic search of Pubmed, Embase and the Cochrane library was performed. Titles and abstracts were evaluated and selected articles were reviewed by two authors. We included randomized controlled trials (RCTs) investigating the effect of vitamin D supplementation during pregnancy on RTIs or wheeze in children of 5 years of age or younger. Observational studies on the association between serum 25-hydroxyvitamin D (25OHD) during pregnancy, or at birth, and RTIs and/or wheeze were included. The protocol was registered on PROSPERO (Registration No. CRD42015019183).RESULTS: Of four RCTs, one showed a protective effect of a high daily dose (2,000IU) of vitamin D during pregnancy on offspring RTI doctor visits (p=0.004; the RCT also included 800IU/day supplement to the infants until six months). Meta-analysis of three RCTs showed a reduced relative risk (RR) for offspring wheeze when mothers were supplemented with vitamin D during pregnancy (RR=0.81 [95% CI 0.68-0.97], p=0.025). In three of four strong quality, and five of ten moderate quality observational studies, an inverse association between pregnancy and cord 25OHD and subsequent wheeze and/or RTI was seen.CONCLUSION: Growing evidence support a preventive role of vitamin D during pregnancy on offspring wheeze and/or RTI. Future intervention studies may need to exceed current recommendations of vitamin D supplementation during pregnancy to show benefit against childhood wheeze or infections.

AB - Respiratory tract infections (RTIs) are a common cause of morbidity and mortality in young children and can be associated with wheeze. Vitamin D can have a protective role against RTI.MATERIALS AND METHODS: A systematic search of Pubmed, Embase and the Cochrane library was performed. Titles and abstracts were evaluated and selected articles were reviewed by two authors. We included randomized controlled trials (RCTs) investigating the effect of vitamin D supplementation during pregnancy on RTIs or wheeze in children of 5 years of age or younger. Observational studies on the association between serum 25-hydroxyvitamin D (25OHD) during pregnancy, or at birth, and RTIs and/or wheeze were included. The protocol was registered on PROSPERO (Registration No. CRD42015019183).RESULTS: Of four RCTs, one showed a protective effect of a high daily dose (2,000IU) of vitamin D during pregnancy on offspring RTI doctor visits (p=0.004; the RCT also included 800IU/day supplement to the infants until six months). Meta-analysis of three RCTs showed a reduced relative risk (RR) for offspring wheeze when mothers were supplemented with vitamin D during pregnancy (RR=0.81 [95% CI 0.68-0.97], p=0.025). In three of four strong quality, and five of ten moderate quality observational studies, an inverse association between pregnancy and cord 25OHD and subsequent wheeze and/or RTI was seen.CONCLUSION: Growing evidence support a preventive role of vitamin D during pregnancy on offspring wheeze and/or RTI. Future intervention studies may need to exceed current recommendations of vitamin D supplementation during pregnancy to show benefit against childhood wheeze or infections.

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DO - 10.1097/INF.0000000000001452

M3 - Review

VL - 36

SP - 384

EP - 391

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 4

ER -