Increasing vaginal progesterone gel supplementation after frozen-thawed embryo transfer significantly increases the delivery rate

Birgit Alsbjerg, Nikolaos P Polyzos, Helle Olesen Elbaek, Betina Boel Povlsen, Claus Yding Andersen, Peter Humaidan

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The aim of this study was to evaluate the reproductive outcome in patients receiving frozen-thawed embryo transfer before and after doubling of the vaginal progesterone gel supplementation. The study was a retrospective study performed in The Fertility Clinic, Skive Regional Hospital, Denmark. A total of 346 infertility patients with oligoamenorrhoea undergoing frozen-thawed embryo transfer after priming with oestradiol and vaginal progesterone gel were included. The vaginal progesterone dose was changed from 90mg (Crinone) once a day to twice a day and the reproductive outcome during the two periods was compared. The pregnancy rate increased significantly after doubling of the progesterone dose (26.7% (90mg) versus 38.4% (180mg); P=0.021). Moreover, the early pregnancy loss rate decreased significantly (67.4% versus 43.7%, respectively; P=0.014), which significantly increased the delivery rate (8.7% versus 20.5%, respectively; P=0.002). Doubling of the vaginal progesterone gel supplementation during frozen-thawed embryo transfer cycles decreased the early pregnancy loss rate, resulting in a significantly higher delivery rate. This study evaluated the reproductive outcome of 346 women with oligoamenorrhoea (cycle length >34 days) or amenorrhoea undergoing oestradiol and progesterone priming prior to frozen-thawed embryo transfer. Patients treated with vaginal progesterone gel (Crinone 90mg) twice daily had a lower risk of pregnancy loss (43.7%) compared with women treated once a day (67.4%). This resulted in a significantly higher delivery rate (20.5% versus 8.7%, respectively).
OriginalsprogEngelsk
TidsskriftReproductive BioMedicine Online
Vol/bind26
Udgave nummer2
Sider (fra-til)133-137
ISSN1472-6483
DOI
StatusUdgivet - 2012

Fingeraftryk

Foams and Jellies Vaginal Creams
Amenorrhea
Denmark
Infertility
Retrospective Studies

Citer dette

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title = "Increasing vaginal progesterone gel supplementation after frozen-thawed embryo transfer significantly increases the delivery rate",
abstract = "The aim of this study was to evaluate the reproductive outcome in patients receiving frozen-thawed embryo transfer before and after doubling of the vaginal progesterone gel supplementation. The study was a retrospective study performed in The Fertility Clinic, Skive Regional Hospital, Denmark. A total of 346 infertility patients with oligoamenorrhoea undergoing frozen-thawed embryo transfer after priming with oestradiol and vaginal progesterone gel were included. The vaginal progesterone dose was changed from 90mg (Crinone) once a day to twice a day and the reproductive outcome during the two periods was compared. The pregnancy rate increased significantly after doubling of the progesterone dose (26.7{\%} (90mg) versus 38.4{\%} (180mg); P=0.021). Moreover, the early pregnancy loss rate decreased significantly (67.4{\%} versus 43.7{\%}, respectively; P=0.014), which significantly increased the delivery rate (8.7{\%} versus 20.5{\%}, respectively; P=0.002). Doubling of the vaginal progesterone gel supplementation during frozen-thawed embryo transfer cycles decreased the early pregnancy loss rate, resulting in a significantly higher delivery rate. This study evaluated the reproductive outcome of 346 women with oligoamenorrhoea (cycle length >34 days) or amenorrhoea undergoing oestradiol and progesterone priming prior to frozen-thawed embryo transfer. Patients treated with vaginal progesterone gel (Crinone 90mg) twice daily had a lower risk of pregnancy loss (43.7{\%}) compared with women treated once a day (67.4{\%}). This resulted in a significantly higher delivery rate (20.5{\%} versus 8.7{\%}, respectively).",
author = "Birgit Alsbjerg and Polyzos, {Nikolaos P} and Elbaek, {Helle Olesen} and Povlsen, {Betina Boel} and Andersen, {Claus Yding} and Peter Humaidan",
note = "Copyright {\circledC} 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.",
year = "2012",
doi = "10.1016/j.rbmo.2012.10.012",
language = "English",
volume = "26",
pages = "133--137",
journal = "Reproductive BioMedicine Online",
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Increasing vaginal progesterone gel supplementation after frozen-thawed embryo transfer significantly increases the delivery rate. / Alsbjerg, Birgit; Polyzos, Nikolaos P; Elbaek, Helle Olesen; Povlsen, Betina Boel; Andersen, Claus Yding; Humaidan, Peter.

I: Reproductive BioMedicine Online, Bind 26, Nr. 2, 2012, s. 133-137.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Increasing vaginal progesterone gel supplementation after frozen-thawed embryo transfer significantly increases the delivery rate

AU - Alsbjerg, Birgit

AU - Polyzos, Nikolaos P

AU - Elbaek, Helle Olesen

AU - Povlsen, Betina Boel

AU - Andersen, Claus Yding

AU - Humaidan, Peter

N1 - Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

PY - 2012

Y1 - 2012

N2 - The aim of this study was to evaluate the reproductive outcome in patients receiving frozen-thawed embryo transfer before and after doubling of the vaginal progesterone gel supplementation. The study was a retrospective study performed in The Fertility Clinic, Skive Regional Hospital, Denmark. A total of 346 infertility patients with oligoamenorrhoea undergoing frozen-thawed embryo transfer after priming with oestradiol and vaginal progesterone gel were included. The vaginal progesterone dose was changed from 90mg (Crinone) once a day to twice a day and the reproductive outcome during the two periods was compared. The pregnancy rate increased significantly after doubling of the progesterone dose (26.7% (90mg) versus 38.4% (180mg); P=0.021). Moreover, the early pregnancy loss rate decreased significantly (67.4% versus 43.7%, respectively; P=0.014), which significantly increased the delivery rate (8.7% versus 20.5%, respectively; P=0.002). Doubling of the vaginal progesterone gel supplementation during frozen-thawed embryo transfer cycles decreased the early pregnancy loss rate, resulting in a significantly higher delivery rate. This study evaluated the reproductive outcome of 346 women with oligoamenorrhoea (cycle length >34 days) or amenorrhoea undergoing oestradiol and progesterone priming prior to frozen-thawed embryo transfer. Patients treated with vaginal progesterone gel (Crinone 90mg) twice daily had a lower risk of pregnancy loss (43.7%) compared with women treated once a day (67.4%). This resulted in a significantly higher delivery rate (20.5% versus 8.7%, respectively).

AB - The aim of this study was to evaluate the reproductive outcome in patients receiving frozen-thawed embryo transfer before and after doubling of the vaginal progesterone gel supplementation. The study was a retrospective study performed in The Fertility Clinic, Skive Regional Hospital, Denmark. A total of 346 infertility patients with oligoamenorrhoea undergoing frozen-thawed embryo transfer after priming with oestradiol and vaginal progesterone gel were included. The vaginal progesterone dose was changed from 90mg (Crinone) once a day to twice a day and the reproductive outcome during the two periods was compared. The pregnancy rate increased significantly after doubling of the progesterone dose (26.7% (90mg) versus 38.4% (180mg); P=0.021). Moreover, the early pregnancy loss rate decreased significantly (67.4% versus 43.7%, respectively; P=0.014), which significantly increased the delivery rate (8.7% versus 20.5%, respectively; P=0.002). Doubling of the vaginal progesterone gel supplementation during frozen-thawed embryo transfer cycles decreased the early pregnancy loss rate, resulting in a significantly higher delivery rate. This study evaluated the reproductive outcome of 346 women with oligoamenorrhoea (cycle length >34 days) or amenorrhoea undergoing oestradiol and progesterone priming prior to frozen-thawed embryo transfer. Patients treated with vaginal progesterone gel (Crinone 90mg) twice daily had a lower risk of pregnancy loss (43.7%) compared with women treated once a day (67.4%). This resulted in a significantly higher delivery rate (20.5% versus 8.7%, respectively).

U2 - 10.1016/j.rbmo.2012.10.012

DO - 10.1016/j.rbmo.2012.10.012

M3 - Journal article

VL - 26

SP - 133

EP - 137

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 2

ER -