Increasing use of antibiotics in pregnancy during the period 2000-2010: prevalence, timing, category, and demographics

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: The aim of this study was to describe the use of antibiotics in a national population-based cohort of pregnant Danish women between 2000 and 2010.

DESIGN: Register-based, population-wide, cohort study.

SETTING: Denmark, from 2000 to 2010.

POPULATION: All pregnancies among Danish residents during the period 2000-2010 were included for analysis.

METHODS: Data were obtained from the Danish Medical Birth Registry, the Danish National Patient Registry, and the Registry of Medicinal Product Statistics. The filled prescriptions for systemic antibacterial, antimycotic, and antiviral drugs, as well as intravaginally applied antibiotics, were analysed. Associations with demographic variables were assessed using multivariate analysis.

MAIN OUTCOME MEASURES: Filled prescriptions for antibiotic drugs during pregnancy.

RESULTS: We included 987 973 pregnancies in Denmark from 2000 to 2010; 38.9% of women with a delivery and 14.8% of women with a miscarriage or termination of pregnancy had one or more antibiotic treatments during pregnancy. Systemic antibacterial drugs were the most frequently used drug group, with filled prescriptions for 33.4% of all deliveries and 12.6% of all abortions. This proportion increased from 28.4% in 2000 to 37.0% in 2010 among deliveries. The biggest change was seen for pivmecillinam, which increased among deliveries from 6.3% in 2000 to 19.5% in 2010. Obese (odds ratio 1.51; 95% CI 1.47-1.56), young (odds ratio 1.35; 95% CI 1.30-1.39), and low-educated women (odds ratio 1.37; 95% CI 1.35-1.1.39) tended to fill more prescriptions of antibiotics during pregnancy.

CONCLUSIONS: Overall, the number of women who filled prescriptions of antibiotics increased during the 11-year study period. In 2010, at least 41.5% of all deliveries were exposed to antibiotic therapy during pregnancy.

OriginalsprogEngelsk
TidsskriftB J O G
Vol/bind121
Udgave nummer8
Sider (fra-til)988-996
ISSN1470-0328
DOI
StatusUdgivet - 2014

Fingeraftryk

Prescriptions
Registries
Odds Ratio
Denmark
Amdinocillin Pivoxil
Spontaneous Abortion
Pharmaceutical Preparations
Pregnant Women
Cohort Studies
Multivariate Analysis
Population

Citer dette

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title = "Increasing use of antibiotics in pregnancy during the period 2000-2010: prevalence, timing, category, and demographics",
abstract = "OBJECTIVE: The aim of this study was to describe the use of antibiotics in a national population-based cohort of pregnant Danish women between 2000 and 2010.DESIGN: Register-based, population-wide, cohort study.SETTING: Denmark, from 2000 to 2010.POPULATION: All pregnancies among Danish residents during the period 2000-2010 were included for analysis.METHODS: Data were obtained from the Danish Medical Birth Registry, the Danish National Patient Registry, and the Registry of Medicinal Product Statistics. The filled prescriptions for systemic antibacterial, antimycotic, and antiviral drugs, as well as intravaginally applied antibiotics, were analysed. Associations with demographic variables were assessed using multivariate analysis.MAIN OUTCOME MEASURES: Filled prescriptions for antibiotic drugs during pregnancy.RESULTS: We included 987 973 pregnancies in Denmark from 2000 to 2010; 38.9{\%} of women with a delivery and 14.8{\%} of women with a miscarriage or termination of pregnancy had one or more antibiotic treatments during pregnancy. Systemic antibacterial drugs were the most frequently used drug group, with filled prescriptions for 33.4{\%} of all deliveries and 12.6{\%} of all abortions. This proportion increased from 28.4{\%} in 2000 to 37.0{\%} in 2010 among deliveries. The biggest change was seen for pivmecillinam, which increased among deliveries from 6.3{\%} in 2000 to 19.5{\%} in 2010. Obese (odds ratio 1.51; 95{\%} CI 1.47-1.56), young (odds ratio 1.35; 95{\%} CI 1.30-1.39), and low-educated women (odds ratio 1.37; 95{\%} CI 1.35-1.1.39) tended to fill more prescriptions of antibiotics during pregnancy.CONCLUSIONS: Overall, the number of women who filled prescriptions of antibiotics increased during the 11-year study period. In 2010, at least 41.5{\%} of all deliveries were exposed to antibiotic therapy during pregnancy.",
author = "Anne Broe and A Potteg{\aa}rd and Lamont, {Ronald Francis} and J{\o}rgensen, {Jan Stener} and P Damkier",
note = "{\circledC} 2014 Royal College of Obstetricians and Gynaecologists.",
year = "2014",
doi = "10.1111/1471-0528.12806",
language = "English",
volume = "121",
pages = "988--996",
journal = "B J O G",
issn = "1470-0328",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Increasing use of antibiotics in pregnancy during the period 2000-2010

T2 - prevalence, timing, category, and demographics

AU - Broe, Anne

AU - Pottegård, A

AU - Lamont, Ronald Francis

AU - Jørgensen, Jan Stener

AU - Damkier, P

N1 - © 2014 Royal College of Obstetricians and Gynaecologists.

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: The aim of this study was to describe the use of antibiotics in a national population-based cohort of pregnant Danish women between 2000 and 2010.DESIGN: Register-based, population-wide, cohort study.SETTING: Denmark, from 2000 to 2010.POPULATION: All pregnancies among Danish residents during the period 2000-2010 were included for analysis.METHODS: Data were obtained from the Danish Medical Birth Registry, the Danish National Patient Registry, and the Registry of Medicinal Product Statistics. The filled prescriptions for systemic antibacterial, antimycotic, and antiviral drugs, as well as intravaginally applied antibiotics, were analysed. Associations with demographic variables were assessed using multivariate analysis.MAIN OUTCOME MEASURES: Filled prescriptions for antibiotic drugs during pregnancy.RESULTS: We included 987 973 pregnancies in Denmark from 2000 to 2010; 38.9% of women with a delivery and 14.8% of women with a miscarriage or termination of pregnancy had one or more antibiotic treatments during pregnancy. Systemic antibacterial drugs were the most frequently used drug group, with filled prescriptions for 33.4% of all deliveries and 12.6% of all abortions. This proportion increased from 28.4% in 2000 to 37.0% in 2010 among deliveries. The biggest change was seen for pivmecillinam, which increased among deliveries from 6.3% in 2000 to 19.5% in 2010. Obese (odds ratio 1.51; 95% CI 1.47-1.56), young (odds ratio 1.35; 95% CI 1.30-1.39), and low-educated women (odds ratio 1.37; 95% CI 1.35-1.1.39) tended to fill more prescriptions of antibiotics during pregnancy.CONCLUSIONS: Overall, the number of women who filled prescriptions of antibiotics increased during the 11-year study period. In 2010, at least 41.5% of all deliveries were exposed to antibiotic therapy during pregnancy.

AB - OBJECTIVE: The aim of this study was to describe the use of antibiotics in a national population-based cohort of pregnant Danish women between 2000 and 2010.DESIGN: Register-based, population-wide, cohort study.SETTING: Denmark, from 2000 to 2010.POPULATION: All pregnancies among Danish residents during the period 2000-2010 were included for analysis.METHODS: Data were obtained from the Danish Medical Birth Registry, the Danish National Patient Registry, and the Registry of Medicinal Product Statistics. The filled prescriptions for systemic antibacterial, antimycotic, and antiviral drugs, as well as intravaginally applied antibiotics, were analysed. Associations with demographic variables were assessed using multivariate analysis.MAIN OUTCOME MEASURES: Filled prescriptions for antibiotic drugs during pregnancy.RESULTS: We included 987 973 pregnancies in Denmark from 2000 to 2010; 38.9% of women with a delivery and 14.8% of women with a miscarriage or termination of pregnancy had one or more antibiotic treatments during pregnancy. Systemic antibacterial drugs were the most frequently used drug group, with filled prescriptions for 33.4% of all deliveries and 12.6% of all abortions. This proportion increased from 28.4% in 2000 to 37.0% in 2010 among deliveries. The biggest change was seen for pivmecillinam, which increased among deliveries from 6.3% in 2000 to 19.5% in 2010. Obese (odds ratio 1.51; 95% CI 1.47-1.56), young (odds ratio 1.35; 95% CI 1.30-1.39), and low-educated women (odds ratio 1.37; 95% CI 1.35-1.1.39) tended to fill more prescriptions of antibiotics during pregnancy.CONCLUSIONS: Overall, the number of women who filled prescriptions of antibiotics increased during the 11-year study period. In 2010, at least 41.5% of all deliveries were exposed to antibiotic therapy during pregnancy.

U2 - 10.1111/1471-0528.12806

DO - 10.1111/1471-0528.12806

M3 - Journal article

C2 - 24754708

VL - 121

SP - 988

EP - 996

JO - B J O G

JF - B J O G

SN - 1470-0328

IS - 8

ER -