Increasing prevalence of coeliac disease in Denmark: a linkage study combining national registries

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Resumé

Aim:  To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time. Methods:  All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records. Results:  Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95% CI 39.3-47.1] to 83.6 [95% CI 78.4-88.7] per 100 000, and the incidence increased from 2.8 [95% CI 1.9-3.9] to 10.0 [95% CI 8.4-12.0] per 100 000; 56% of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95% CI 0.3-1.4] to 6.9 [95% CI 5.4-8.4] per 100 000. The mean age at diagnosis increased from 5.1 [95% CI 3.5-6.6] to 8.1 [95% CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time. Conclusion:  The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.
OriginalsprogEngelsk
TidsskriftActa Paediatrica
Vol/bind101
Udgave nummer2
Sider (fra-til)179-184
ISSN0803-5253
DOI
StatusUdgivet - 2011

Fingeraftryk

Celiac Disease
Denmark
Registries
Incidence
Pathology
Hospital Records

Citer dette

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title = "Increasing prevalence of coeliac disease in Denmark: a linkage study combining national registries",
abstract = "Aim:  To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time. Methods:  All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records. Results:  Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95{\%} CI 39.3-47.1] to 83.6 [95{\%} CI 78.4-88.7] per 100 000, and the incidence increased from 2.8 [95{\%} CI 1.9-3.9] to 10.0 [95{\%} CI 8.4-12.0] per 100 000; 56{\%} of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95{\%} CI 0.3-1.4] to 6.9 [95{\%} CI 5.4-8.4] per 100 000. The mean age at diagnosis increased from 5.1 [95{\%} CI 3.5-6.6] to 8.1 [95{\%} CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time. Conclusion:  The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.",
author = "Stine Dydensborg and Peter Toftedal and Matteo Biaggi and Lillevang, {S{\o}ren T} and Hansen, {Dorte G} and Steffen Husby",
note = "{\circledC} 2011 The Author(s)/Acta Paediatrica {\circledC} 2011 Foundation Acta Paediatrica.",
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Increasing prevalence of coeliac disease in Denmark: a linkage study combining national registries. / Dydensborg, Stine; Toftedal, Peter; Biaggi, Matteo; Lillevang, Søren T; Hansen, Dorte G; Husby, Steffen.

I: Acta Paediatrica, Bind 101, Nr. 2, 2011, s. 179-184.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Increasing prevalence of coeliac disease in Denmark: a linkage study combining national registries

AU - Dydensborg, Stine

AU - Toftedal, Peter

AU - Biaggi, Matteo

AU - Lillevang, Søren T

AU - Hansen, Dorte G

AU - Husby, Steffen

N1 - © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

PY - 2011

Y1 - 2011

N2 - Aim:  To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time. Methods:  All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records. Results:  Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95% CI 39.3-47.1] to 83.6 [95% CI 78.4-88.7] per 100 000, and the incidence increased from 2.8 [95% CI 1.9-3.9] to 10.0 [95% CI 8.4-12.0] per 100 000; 56% of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95% CI 0.3-1.4] to 6.9 [95% CI 5.4-8.4] per 100 000. The mean age at diagnosis increased from 5.1 [95% CI 3.5-6.6] to 8.1 [95% CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time. Conclusion:  The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.

AB - Aim:  To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time. Methods:  All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records. Results:  Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95% CI 39.3-47.1] to 83.6 [95% CI 78.4-88.7] per 100 000, and the incidence increased from 2.8 [95% CI 1.9-3.9] to 10.0 [95% CI 8.4-12.0] per 100 000; 56% of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95% CI 0.3-1.4] to 6.9 [95% CI 5.4-8.4] per 100 000. The mean age at diagnosis increased from 5.1 [95% CI 3.5-6.6] to 8.1 [95% CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time. Conclusion:  The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.

U2 - 10.1111/j.1651-2227.2011.02392.x

DO - 10.1111/j.1651-2227.2011.02392.x

M3 - Journal article

VL - 101

SP - 179

EP - 184

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 2

ER -