Increased transient receptor potential vanilloid type 1 (TRPV1) channel expression in hypertrophic heart

Florian Thilo, Ying Liu, Nico Schulz, Ulrich Gergs, Joachim Neumann, Christoph Loddenkemper, Maik Gollasch, Martin Tepel

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Abstrakt

The aim of this study was to compare the expression of transient receptor potential vanilloid type 1 (TRPV1) channels in hypertrophic hearts from transgenic mice showing overexpression of the catalytic subunit alpha of protein phosphatase 2A alpha (PP2Ac alpha) with wild-type mice and with TRPV1-/- mice. Transcripts of TRPV1, matrix metalloproteinase 9 (MMP9), discoidin domain receptor family, member 2 (DDR-2), atrial natriuretic peptide (ANP), GATA 4, and regulatory microRNA (miR-21) were analyzed using quantitative real-time PCR. Ventricle-to-body-weight-ratio was significantly higher in PP2Ac alpha transgenic mice compared to wild-type mice and TRPV1-/- mice (8.6±1.3mg/g; 5.4±0.3mg/g; and 5.4±0.4mg/g; respectively; p
OriginalsprogEngelsk
TidsskriftBiochemical and Biophysical Research Communications
Vol/bind401
Udgave nummer1
Sider (fra-til)98-103
Antal sider6
ISSN0006-291X
DOI
StatusUdgivet - 8. okt. 2010

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