Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension

Dao Yan Liu, Florian Thilo, Alexandra Scholze, Antje Wittstock, Zhi Gang Zhao, Christian Harteneck, Walter Zidek, Zhi Ming Zhu, Martin Tepel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Activation of nonselective cation channels of the transient receptor potential canonical (TRPC) family has been associated with hypertension. Whether store-operated channels, which are activated after depletion of intracellular stores, or second-messenger-operated channels, which are activated by 1-oleoyl-2-acetyl-sn-glycerol, are affected in essential hypertension is presently unknown.
OriginalsprogEngelsk
TidsskriftJournal of Hypertension
Vol/bind25
Udgave nummer4
Sider (fra-til)799-808
Antal sider10
ISSN0263-6352
DOI
StatusUdgivet - 2007

Fingeraftryk

Essential Hypertension
1-oleoyl-2-acetylglycerol

Citer dette

@article{15a00aab3fd54a99bd0e50587a859b53,
title = "Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension",
abstract = "Activation of nonselective cation channels of the transient receptor potential canonical (TRPC) family has been associated with hypertension. Whether store-operated channels, which are activated after depletion of intracellular stores, or second-messenger-operated channels, which are activated by 1-oleoyl-2-acetyl-sn-glycerol, are affected in essential hypertension is presently unknown.",
keywords = "Aged, Blotting, Western, Calcium, Calcium Channels, Case-Control Studies, Diglycerides, Dose-Response Relationship, Drug, Down-Regulation, Female, Fluorescence, Humans, Hypertension, Male, Middle Aged, Monocytes, RNA Interference, RNA, Messenger, Research Design, Reverse Transcriptase Polymerase Chain Reaction, TRPC Cation Channels",
author = "Liu, {Dao Yan} and Florian Thilo and Alexandra Scholze and Antje Wittstock and Zhao, {Zhi Gang} and Christian Harteneck and Walter Zidek and Zhu, {Zhi Ming} and Martin Tepel",
year = "2007",
doi = "10.1097/HJH.0b013e32803cae2b",
language = "English",
volume = "25",
pages = "799--808",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "4",

}

Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension. / Liu, Dao Yan; Thilo, Florian; Scholze, Alexandra; Wittstock, Antje; Zhao, Zhi Gang; Harteneck, Christian; Zidek, Walter; Zhu, Zhi Ming; Tepel, Martin.

I: Journal of Hypertension, Bind 25, Nr. 4, 2007, s. 799-808.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension

AU - Liu, Dao Yan

AU - Thilo, Florian

AU - Scholze, Alexandra

AU - Wittstock, Antje

AU - Zhao, Zhi Gang

AU - Harteneck, Christian

AU - Zidek, Walter

AU - Zhu, Zhi Ming

AU - Tepel, Martin

PY - 2007

Y1 - 2007

N2 - Activation of nonselective cation channels of the transient receptor potential canonical (TRPC) family has been associated with hypertension. Whether store-operated channels, which are activated after depletion of intracellular stores, or second-messenger-operated channels, which are activated by 1-oleoyl-2-acetyl-sn-glycerol, are affected in essential hypertension is presently unknown.

AB - Activation of nonselective cation channels of the transient receptor potential canonical (TRPC) family has been associated with hypertension. Whether store-operated channels, which are activated after depletion of intracellular stores, or second-messenger-operated channels, which are activated by 1-oleoyl-2-acetyl-sn-glycerol, are affected in essential hypertension is presently unknown.

KW - Aged

KW - Blotting, Western

KW - Calcium

KW - Calcium Channels

KW - Case-Control Studies

KW - Diglycerides

KW - Dose-Response Relationship, Drug

KW - Down-Regulation

KW - Female

KW - Fluorescence

KW - Humans

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Monocytes

KW - RNA Interference

KW - RNA, Messenger

KW - Research Design

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - TRPC Cation Channels

U2 - 10.1097/HJH.0b013e32803cae2b

DO - 10.1097/HJH.0b013e32803cae2b

M3 - Journal article

VL - 25

SP - 799

EP - 808

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 4

ER -