Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer

M. H. Hvolris; Thomas B Piper; E. Hammer; L. N. Jorgensen; J Olsen; H. B. Rahr; Knud T Nielsen; S Laurberg; I J Christensen; N Brunner; J. S. Johansen; G. J. Davis; Barry L Dowell; H. J. Nielsen

doi:10.3109/00365521.2016.1144783

Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer

M. H. Hvolris
, Thomas B Piper
, E. Hammer
, L. N. Jorgensen
, J Olsen
, H. B. Rahr
, Knud T Nielsen
, S Laurberg
, I J Christensen
, N Brunner
, J. S. Johansen
, G. J. Davis
, Barry L Dowell
, H. J. Nielsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Background: Frequently, subjects offered colonoscopy due to symptoms of colorectal neoplasia are diagnosed with diverticula. The symptoms may, however, also be related to extra-colonic neoplasia. The present retrospective study evaluated a possible association between increased levels of predefined biomarkers in subjects diagnosed with diverticula and risk of developing a primary malignant disease. Methods: During 2004/2005, about 4509 subjects were included in a multicenter study with collection of blood samples before bowel endoscopy. The aim was to evaluate a relation between the protein biomarkers CEA, TIMP-1, CA19-9 and YKL-40 and findings at endoscopy. Diverticula were diagnosed in 1021 subjects. By 31 December 2012, subjects who had developed primary malignancy were identified retrospectively and relation between biomarker levels at endoscopy and risk of developing primary malignancy was calculated. The relation with the four biomarkers was divided into three groups: 0 = none increased; 1 = one increased and 2 = two or more increased. Results: In the observation period, 148 subjects developed a primary malignant disease. Univariable analyzes of the biomarker levels showed that CEA, TIMP-1 and CA19-9 were significantly associated with development of primary malignancy. A multivariable analysis showed that increased levels were associated with development of malignancy (p< 0.0001). The 1-and 5-year cumulative risks of being diagnosed with a primary malignancy were: group 0: 1.1%/5.5%; group 1: 4.2%/10.1% and group 2: 11.4%/18.8%, respectively. Conclusion: Increased levels of CEA, TIMP-1 and CA19-9 at endoscopy with findings of diverticula were associated with a significantly increased risk of being diagnosed with a subsequent primary malignant disease.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Gastroenterology
Vol/bind	51
Udgave nummer	7
Sider (fra-til)	860-865
ISSN	0036-5521
DOI	https://doi.org/10.3109/00365521.2016.1144783
Status	Udgivet - jul. 2016

Bibliografisk note

ISI Document Delivery No.: DO0EE Times Cited: 1 Cited Reference Count: 25 Hvolris, Martin H. Piper, Thomas B. Hammer, Emilie Jorgensen, Lars N. Olsen, Jesper Rahr, Hans B. Nielsen, Knud T. Laurberg, Soren Christensen, Ib J. Brunner, Nils Johansen, Julia S. Davis, Gerard J. Dowell, Barry L. Nielsen, Hans J. Danish Cancer Society; Kornerup Fund; Aage and Johanne Louis-Hansen Fund; Aase and Ejnar Danielsen Fund; Walter and O. Kristiane Christensen Fund; Kathrine and Vigo Skovgaard Fund; Den Midtjyske Bladfond; Agnes and Poul Friis Fund; Glunz and Jensen Fund; Sophus and Astrid Jacobsen Fund; Arvid Nilsson Fund; Danish Bank Fund; Johannes Fog Fund; Eva and Henry Fraenkel Fund; Hartmann Bros. Fund; KID Fund; Henrik Henriksen Fund; King Christian X's Fund; Oda and Hans Svenningsen Fund; Else and Mogens Wedell-Wedellsborg Fund; Einar Willumsen Fund; Willy and Ingeborg Reinhard Fund; Friedrich and Else Boehm Fund; Toyota Fund Denmark; IMK Fund; Danish Medical Research Fund; Beckett Fund; Hvidovre University Hospital The study received financial support from The Danish Cancer Society, The Kornerup Fund, The Aage and Johanne Louis-Hansen Fund, The Aase and Ejnar Danielsen Fund, The Walter and O. Kristiane Christensen Fund, The Kathrine and Vigo Skovgaard Fund, Den Midtjyske Bladfond, The Agnes and Poul Friis Fund, The Glunz and Jensen Fund, The Sophus and Astrid Jacobsen Fund, The Arvid Nilsson Fund, The Danish Bank Fund, The Johannes Fog Fund, The Eva and Henry Fraenkel Fund, The Hartmann Bros. Fund, The KID Fund, The Henrik Henriksen Fund, The King Christian X's Fund, The Oda and Hans Svenningsen Fund, The Else and Mogens Wedell-Wedellsborg Fund, The Einar Willumsen Fund, The Willy and Ingeborg Reinhard Fund, The Friedrich and Else Boehm Fund, The Toyota Fund Denmark, The IMK Fund, The Danish Medical Research Fund, The Beckett Fund and Hvidovre University Hospital. 1 0 2 Taylor & francis ltd Abingdon 1502-7708

Dokumenter og links

10.3109/00365521.2016.1144783

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Hvolris, M. H., Piper, T. B., Hammer, E., Jorgensen, L. N., Olsen, J., Rahr, H. B., Nielsen, K. T., Laurberg, S., Christensen, I. J., Brunner, N., Johansen, J. S., Davis, G. J., Dowell, B. L., & Nielsen, H. J. (2016). Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer. Scandinavian Journal of Gastroenterology, 51(7), 860-865. https://doi.org/10.3109/00365521.2016.1144783

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title = "Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer",

abstract = "Background: Frequently, subjects offered colonoscopy due to symptoms of colorectal neoplasia are diagnosed with diverticula. The symptoms may, however, also be related to extra-colonic neoplasia. The present retrospective study evaluated a possible association between increased levels of predefined biomarkers in subjects diagnosed with diverticula and risk of developing a primary malignant disease. Methods: During 2004/2005, about 4509 subjects were included in a multicenter study with collection of blood samples before bowel endoscopy. The aim was to evaluate a relation between the protein biomarkers CEA, TIMP-1, CA19-9 and YKL-40 and findings at endoscopy. Diverticula were diagnosed in 1021 subjects. By 31 December 2012, subjects who had developed primary malignancy were identified retrospectively and relation between biomarker levels at endoscopy and risk of developing primary malignancy was calculated. The relation with the four biomarkers was divided into three groups: 0 = none increased; 1 = one increased and 2 = two or more increased. Results: In the observation period, 148 subjects developed a primary malignant disease. Univariable analyzes of the biomarker levels showed that CEA, TIMP-1 and CA19-9 were significantly associated with development of primary malignancy. A multivariable analysis showed that increased levels were associated with development of malignancy (p< 0.0001). The 1-and 5-year cumulative risks of being diagnosed with a primary malignancy were: group 0: 1.1\%/5.5\%; group 1: 4.2\%/10.1\% and group 2: 11.4\%/18.8\%, respectively. Conclusion: Increased levels of CEA, TIMP-1 and CA19-9 at endoscopy with findings of diverticula were associated with a significantly increased risk of being diagnosed with a subsequent primary malignant disease.",

keywords = "CA19-9 CEA colorectal cancer diverticula endoscopy malignancy TIMP-1 YKL-40 c-reactive protein primary colorectal-cancer diverticular-disease uncomplicated diverticulitis plasma timp-1 population individuals ykl-40 tests cea Gastroenterology \& Hepatology, TIMP-1, colorectal cancer, malignancy, endoscopy, YKL-40, diverticula, CA19-9, CEA, Diverticulum, Colon/diagnosis, Prospective Studies, Humans, Middle Aged, Male, Antigens, Tumor-Associated, Carbohydrate/blood, Colorectal Neoplasms/blood, Tissue Inhibitor of Metalloproteinase-1/blood, Aged, 80 and over, Adult, Female, Retrospective Studies, Intestinal Neoplasms/pathology, Biomarkers, Tumor/blood, Endoscopy, Gastrointestinal, Aged, Chitinase-3-Like Protein 1/blood",

author = "Hvolris, \{M. H.\} and Piper, \{Thomas B\} and E. Hammer and Jorgensen, \{L. N.\} and J Olsen and Rahr, \{H. B.\} and Nielsen, \{Knud T\} and S Laurberg and Christensen, \{I J\} and N Brunner and Johansen, \{J. S.\} and Davis, \{G. J.\} and Dowell, \{Barry L\} and Nielsen, \{H. J.\}",

note = "ISI Document Delivery No.: DO0EE Times Cited: 1 Cited Reference Count: 25 Hvolris, Martin H. Piper, Thomas B. Hammer, Emilie Jorgensen, Lars N. Olsen, Jesper Rahr, Hans B. Nielsen, Knud T. Laurberg, Soren Christensen, Ib J. Brunner, Nils Johansen, Julia S. Davis, Gerard J. Dowell, Barry L. Nielsen, Hans J. Danish Cancer Society; Kornerup Fund; Aage and Johanne Louis-Hansen Fund; Aase and Ejnar Danielsen Fund; Walter and O. Kristiane Christensen Fund; Kathrine and Vigo Skovgaard Fund; Den Midtjyske Bladfond; Agnes and Poul Friis Fund; Glunz and Jensen Fund; Sophus and Astrid Jacobsen Fund; Arvid Nilsson Fund; Danish Bank Fund; Johannes Fog Fund; Eva and Henry Fraenkel Fund; Hartmann Bros. Fund; KID Fund; Henrik Henriksen Fund; King Christian X's Fund; Oda and Hans Svenningsen Fund; Else and Mogens Wedell-Wedellsborg Fund; Einar Willumsen Fund; Willy and Ingeborg Reinhard Fund; Friedrich and Else Boehm Fund; Toyota Fund Denmark; IMK Fund; Danish Medical Research Fund; Beckett Fund; Hvidovre University Hospital The study received financial support from The Danish Cancer Society, The Kornerup Fund, The Aage and Johanne Louis-Hansen Fund, The Aase and Ejnar Danielsen Fund, The Walter and O. Kristiane Christensen Fund, The Kathrine and Vigo Skovgaard Fund, Den Midtjyske Bladfond, The Agnes and Poul Friis Fund, The Glunz and Jensen Fund, The Sophus and Astrid Jacobsen Fund, The Arvid Nilsson Fund, The Danish Bank Fund, The Johannes Fog Fund, The Eva and Henry Fraenkel Fund, The Hartmann Bros. Fund, The KID Fund, The Henrik Henriksen Fund, The King Christian X's Fund, The Oda and Hans Svenningsen Fund, The Else and Mogens Wedell-Wedellsborg Fund, The Einar Willumsen Fund, The Willy and Ingeborg Reinhard Fund, The Friedrich and Else Boehm Fund, The Toyota Fund Denmark, The IMK Fund, The Danish Medical Research Fund, The Beckett Fund and Hvidovre University Hospital. 1 0 2 Taylor \& francis ltd Abingdon 1502-7708",

year = "2016",

month = jul,

doi = "10.3109/00365521.2016.1144783",

language = "English",

volume = "51",

pages = "860--865",

journal = "Scandinavian Journal of Gastroenterology",

issn = "0036-5521",

publisher = "Taylor \& Francis",

number = "7",

}

Hvolris, MH, Piper, TB, Hammer, E, Jorgensen, LN, Olsen, J, Rahr, HB, Nielsen, KT, Laurberg, S, Christensen, IJ, Brunner, N, Johansen, JS, Davis, GJ, Dowell, BL & Nielsen, HJ 2016, 'Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer', Scandinavian Journal of Gastroenterology, bind 51, nr. 7, s. 860-865. https://doi.org/10.3109/00365521.2016.1144783

TY - JOUR

T1 - Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer

AU - Hvolris, M. H.

AU - Piper, Thomas B

AU - Hammer, E.

AU - Jorgensen, L. N.

AU - Olsen, J

AU - Rahr, H. B.

AU - Nielsen, Knud T

AU - Laurberg, S

AU - Christensen, I J

AU - Brunner, N

AU - Johansen, J. S.

AU - Davis, G. J.

AU - Dowell, Barry L

AU - Nielsen, H. J.

N1 - ISI Document Delivery No.: DO0EE Times Cited: 1 Cited Reference Count: 25 Hvolris, Martin H. Piper, Thomas B. Hammer, Emilie Jorgensen, Lars N. Olsen, Jesper Rahr, Hans B. Nielsen, Knud T. Laurberg, Soren Christensen, Ib J. Brunner, Nils Johansen, Julia S. Davis, Gerard J. Dowell, Barry L. Nielsen, Hans J. Danish Cancer Society; Kornerup Fund; Aage and Johanne Louis-Hansen Fund; Aase and Ejnar Danielsen Fund; Walter and O. Kristiane Christensen Fund; Kathrine and Vigo Skovgaard Fund; Den Midtjyske Bladfond; Agnes and Poul Friis Fund; Glunz and Jensen Fund; Sophus and Astrid Jacobsen Fund; Arvid Nilsson Fund; Danish Bank Fund; Johannes Fog Fund; Eva and Henry Fraenkel Fund; Hartmann Bros. Fund; KID Fund; Henrik Henriksen Fund; King Christian X's Fund; Oda and Hans Svenningsen Fund; Else and Mogens Wedell-Wedellsborg Fund; Einar Willumsen Fund; Willy and Ingeborg Reinhard Fund; Friedrich and Else Boehm Fund; Toyota Fund Denmark; IMK Fund; Danish Medical Research Fund; Beckett Fund; Hvidovre University Hospital The study received financial support from The Danish Cancer Society, The Kornerup Fund, The Aage and Johanne Louis-Hansen Fund, The Aase and Ejnar Danielsen Fund, The Walter and O. Kristiane Christensen Fund, The Kathrine and Vigo Skovgaard Fund, Den Midtjyske Bladfond, The Agnes and Poul Friis Fund, The Glunz and Jensen Fund, The Sophus and Astrid Jacobsen Fund, The Arvid Nilsson Fund, The Danish Bank Fund, The Johannes Fog Fund, The Eva and Henry Fraenkel Fund, The Hartmann Bros. Fund, The KID Fund, The Henrik Henriksen Fund, The King Christian X's Fund, The Oda and Hans Svenningsen Fund, The Else and Mogens Wedell-Wedellsborg Fund, The Einar Willumsen Fund, The Willy and Ingeborg Reinhard Fund, The Friedrich and Else Boehm Fund, The Toyota Fund Denmark, The IMK Fund, The Danish Medical Research Fund, The Beckett Fund and Hvidovre University Hospital. 1 0 2 Taylor & francis ltd Abingdon 1502-7708

PY - 2016/7

Y1 - 2016/7

N2 - Background: Frequently, subjects offered colonoscopy due to symptoms of colorectal neoplasia are diagnosed with diverticula. The symptoms may, however, also be related to extra-colonic neoplasia. The present retrospective study evaluated a possible association between increased levels of predefined biomarkers in subjects diagnosed with diverticula and risk of developing a primary malignant disease. Methods: During 2004/2005, about 4509 subjects were included in a multicenter study with collection of blood samples before bowel endoscopy. The aim was to evaluate a relation between the protein biomarkers CEA, TIMP-1, CA19-9 and YKL-40 and findings at endoscopy. Diverticula were diagnosed in 1021 subjects. By 31 December 2012, subjects who had developed primary malignancy were identified retrospectively and relation between biomarker levels at endoscopy and risk of developing primary malignancy was calculated. The relation with the four biomarkers was divided into three groups: 0 = none increased; 1 = one increased and 2 = two or more increased. Results: In the observation period, 148 subjects developed a primary malignant disease. Univariable analyzes of the biomarker levels showed that CEA, TIMP-1 and CA19-9 were significantly associated with development of primary malignancy. A multivariable analysis showed that increased levels were associated with development of malignancy (p< 0.0001). The 1-and 5-year cumulative risks of being diagnosed with a primary malignancy were: group 0: 1.1%/5.5%; group 1: 4.2%/10.1% and group 2: 11.4%/18.8%, respectively. Conclusion: Increased levels of CEA, TIMP-1 and CA19-9 at endoscopy with findings of diverticula were associated with a significantly increased risk of being diagnosed with a subsequent primary malignant disease.

AB - Background: Frequently, subjects offered colonoscopy due to symptoms of colorectal neoplasia are diagnosed with diverticula. The symptoms may, however, also be related to extra-colonic neoplasia. The present retrospective study evaluated a possible association between increased levels of predefined biomarkers in subjects diagnosed with diverticula and risk of developing a primary malignant disease. Methods: During 2004/2005, about 4509 subjects were included in a multicenter study with collection of blood samples before bowel endoscopy. The aim was to evaluate a relation between the protein biomarkers CEA, TIMP-1, CA19-9 and YKL-40 and findings at endoscopy. Diverticula were diagnosed in 1021 subjects. By 31 December 2012, subjects who had developed primary malignancy were identified retrospectively and relation between biomarker levels at endoscopy and risk of developing primary malignancy was calculated. The relation with the four biomarkers was divided into three groups: 0 = none increased; 1 = one increased and 2 = two or more increased. Results: In the observation period, 148 subjects developed a primary malignant disease. Univariable analyzes of the biomarker levels showed that CEA, TIMP-1 and CA19-9 were significantly associated with development of primary malignancy. A multivariable analysis showed that increased levels were associated with development of malignancy (p< 0.0001). The 1-and 5-year cumulative risks of being diagnosed with a primary malignancy were: group 0: 1.1%/5.5%; group 1: 4.2%/10.1% and group 2: 11.4%/18.8%, respectively. Conclusion: Increased levels of CEA, TIMP-1 and CA19-9 at endoscopy with findings of diverticula were associated with a significantly increased risk of being diagnosed with a subsequent primary malignant disease.

KW - CA19-9 CEA colorectal cancer diverticula endoscopy malignancy TIMP-1 YKL-40 c-reactive protein primary colorectal-cancer diverticular-disease uncomplicated diverticulitis plasma timp-1 population individuals ykl-40 tests cea Gastroenterology & Hepatology

KW - TIMP-1

KW - colorectal cancer

KW - malignancy

KW - endoscopy

KW - YKL-40

KW - diverticula

KW - CA19-9

KW - CEA

KW - Diverticulum, Colon/diagnosis

KW - Prospective Studies

KW - Humans

KW - Middle Aged

KW - Male

KW - Antigens, Tumor-Associated, Carbohydrate/blood

KW - Colorectal Neoplasms/blood

KW - Tissue Inhibitor of Metalloproteinase-1/blood

KW - Aged, 80 and over

KW - Adult

KW - Female

KW - Retrospective Studies

KW - Intestinal Neoplasms/pathology

KW - Biomarkers, Tumor/blood

KW - Endoscopy, Gastrointestinal

KW - Aged

KW - Chitinase-3-Like Protein 1/blood

U2 - 10.3109/00365521.2016.1144783

DO - 10.3109/00365521.2016.1144783

M3 - Journal article

C2 - 26918701

SN - 0036-5521

VL - 51

SP - 860

EP - 865

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 7

ER -

Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer

Abstract

Bibliografisk note

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater