Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings

Thomas Andersen, Tue Kruse Rasmussen, Malene Hvid, Christian Kanstrup Holm, Karen Jong-Nyo Berenth Madsen, Anne Grethe Jurik, Marianne Hokland, Kristian Stengaard-Pedersen, Berit Schiøttz-Christensen, Bent Deleuran

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Abstrakt

We have investigated the role of the Th17-related cytokines interleukin-17A (IL-17A), IL-21, and IL-23 in spondyloarthritis (SpA) by examining their association with disease activity and magnetic resonance imaging (MRI) findings in patients with SpA (n = 80). Furthermore, to investigate the cellular origins of the cytokines, paired mononuclear cells from blood and synovial fluid were examined for the expression of IL-17A, IL-21, and IL-23R using multicolor flow cytometry. Both IL-21 and IL-23 levels were increased in plasma from SpA patients compared with healthy volunteers (P < 0.05), whereas IL-17A was not. A significant correlation was observed between individual levels of IL-21 and IL-23 (r = 0.7, P < 0.001). No association between individual levels of IL-17A, IL-21, and IL-23 with C-reactive protein (CRP), MRI changes, and clinical scoring (BASMI, BASFI, and BASDAI) were observed. The frequency of CD4+CD45RO+ T cells expressing IL-21 and IL-23R was increased in the inflamed SpA joint compared to peripheral blood (P < 0.05). This study demonstrate that the plasma levels of the Th17-related cytokines IL-21 and IL-23, but not IL-17A, are increased in SpA patients, but we did not find evidence that the level of these cytokines reflect disease activity in SpA.

OriginalsprogEngelsk
TidsskriftRheumatology International
Vol/bind32
Udgave nummer2
Sider (fra-til)387-93
ISSN0172-8172
DOI
StatusUdgivet - 2012

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