Increased mortality associated with low use of clopidogrel in patients with heart failure and acute myocardial infarction not undergoing percutaneous coronary intervention: a nationwide study

Lisbeth Bonde, Rikke Sorensen, Emil Loldrup Fosbøl, Steen Zabell Abildstrøm, Peter Riis Hansen, Lars Kober, Tina Ken Schramm, Ditte-Marie Bretler, Peter Weeke, Jonas Olesen, Christian Torp-Pedersen, Gunnar Hilmar Gislason

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVES: We studied the association of clopidogrel with mortality in acute myocardial infarction (AMI) patients with heart failure (HF) not receiving percutaneous coronary intervention (PCI).

BACKGROUND: Use of clopidogrel after AMI is low in patients with HF, despite the fact that clopidogrel is associated with absolute mortality reduction in AMI patients.

METHODS: All patients hospitalized with first-time AMI (2000 through 2005) and not undergoing PCI within 30 days from discharge were identified in national registers. Patients with HF treated with clopidogrel were matched by propensity score with patients not treated with clopidogrel. Similarly, 2 groups without HF were identified. Risks of all-cause death were obtained by the Kaplan-Meier method and Cox regression analyses.

RESULTS: We identified 56,944 patients with first-time AMI. In the matched cohort with HF (n = 5,050) and a mean follow-up of 1.50 years (SD = 1.2), 709 (28.1%) and 812 (32.2%) deaths occurred in patients receiving and not receiving clopidogrel treatment, respectively (p = 0.002). The corresponding numbers for patients without HF (n = 6,092), with a mean follow-up of 2.05 years (SD = 1.3), were 285 (9.4%) and 294 (9.7%), respectively (p = 0.83). Patients with HF receiving clopidogrel demonstrated reduced mortality (hazard ratio: 0.86; 95% confidence interval: 0.78 to 0.95) compared with patients with HF not receiving clopidogrel. No difference was observed among patients without HF (hazard ratio: 0.98; 95% confidence interval: 0.83 to 1.16).

CONCLUSIONS: Clopidogrel was associated with reduced mortality in patients with HF who do not undergo PCI after their first-time AMI, whereas this association was not apparent in patients without HF. Further studies of the benefit of clopidogrel in patients with HF and AMI are warranted.

OriginalsprogEngelsk
TidsskriftAmerican College of Cardiology. Journal
Vol/bind55
Udgave nummer13
Sider (fra-til)1300-7
Antal sider8
ISSN0735-1097
DOI
StatusUdgivet - 30. mar. 2010

Fingeraftryk

clopidogrel

Citer dette

Bonde, Lisbeth ; Sorensen, Rikke ; Fosbøl, Emil Loldrup ; Abildstrøm, Steen Zabell ; Hansen, Peter Riis ; Kober, Lars ; Schramm, Tina Ken ; Bretler, Ditte-Marie ; Weeke, Peter ; Olesen, Jonas ; Torp-Pedersen, Christian ; Gislason, Gunnar Hilmar. / Increased mortality associated with low use of clopidogrel in patients with heart failure and acute myocardial infarction not undergoing percutaneous coronary intervention : a nationwide study. I: American College of Cardiology. Journal. 2010 ; Bind 55, Nr. 13. s. 1300-7.
@article{9f758861cfd24186a6965c291d81fc3d,
title = "Increased mortality associated with low use of clopidogrel in patients with heart failure and acute myocardial infarction not undergoing percutaneous coronary intervention: a nationwide study",
abstract = "OBJECTIVES: We studied the association of clopidogrel with mortality in acute myocardial infarction (AMI) patients with heart failure (HF) not receiving percutaneous coronary intervention (PCI).BACKGROUND: Use of clopidogrel after AMI is low in patients with HF, despite the fact that clopidogrel is associated with absolute mortality reduction in AMI patients.METHODS: All patients hospitalized with first-time AMI (2000 through 2005) and not undergoing PCI within 30 days from discharge were identified in national registers. Patients with HF treated with clopidogrel were matched by propensity score with patients not treated with clopidogrel. Similarly, 2 groups without HF were identified. Risks of all-cause death were obtained by the Kaplan-Meier method and Cox regression analyses.RESULTS: We identified 56,944 patients with first-time AMI. In the matched cohort with HF (n = 5,050) and a mean follow-up of 1.50 years (SD = 1.2), 709 (28.1{\%}) and 812 (32.2{\%}) deaths occurred in patients receiving and not receiving clopidogrel treatment, respectively (p = 0.002). The corresponding numbers for patients without HF (n = 6,092), with a mean follow-up of 2.05 years (SD = 1.3), were 285 (9.4{\%}) and 294 (9.7{\%}), respectively (p = 0.83). Patients with HF receiving clopidogrel demonstrated reduced mortality (hazard ratio: 0.86; 95{\%} confidence interval: 0.78 to 0.95) compared with patients with HF not receiving clopidogrel. No difference was observed among patients without HF (hazard ratio: 0.98; 95{\%} confidence interval: 0.83 to 1.16).CONCLUSIONS: Clopidogrel was associated with reduced mortality in patients with HF who do not undergo PCI after their first-time AMI, whereas this association was not apparent in patients without HF. Further studies of the benefit of clopidogrel in patients with HF and AMI are warranted.",
keywords = "Adult, Aged, Angioplasty, Balloon, Coronary, Denmark, Female, Heart Failure, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Proportional Hazards Models, Survival Analysis, Ticlopidine, Journal Article",
author = "Lisbeth Bonde and Rikke Sorensen and Fosb{\o}l, {Emil Loldrup} and Abildstr{\o}m, {Steen Zabell} and Hansen, {Peter Riis} and Lars Kober and Schramm, {Tina Ken} and Ditte-Marie Bretler and Peter Weeke and Jonas Olesen and Christian Torp-Pedersen and Gislason, {Gunnar Hilmar}",
year = "2010",
month = "3",
day = "30",
doi = "10.1016/j.jacc.2009.11.057",
language = "English",
volume = "55",
pages = "1300--7",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Heinemann",
number = "13",

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Increased mortality associated with low use of clopidogrel in patients with heart failure and acute myocardial infarction not undergoing percutaneous coronary intervention : a nationwide study. / Bonde, Lisbeth; Sorensen, Rikke; Fosbøl, Emil Loldrup; Abildstrøm, Steen Zabell; Hansen, Peter Riis; Kober, Lars; Schramm, Tina Ken; Bretler, Ditte-Marie; Weeke, Peter; Olesen, Jonas; Torp-Pedersen, Christian; Gislason, Gunnar Hilmar.

I: American College of Cardiology. Journal, Bind 55, Nr. 13, 30.03.2010, s. 1300-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Increased mortality associated with low use of clopidogrel in patients with heart failure and acute myocardial infarction not undergoing percutaneous coronary intervention

T2 - a nationwide study

AU - Bonde, Lisbeth

AU - Sorensen, Rikke

AU - Fosbøl, Emil Loldrup

AU - Abildstrøm, Steen Zabell

AU - Hansen, Peter Riis

AU - Kober, Lars

AU - Schramm, Tina Ken

AU - Bretler, Ditte-Marie

AU - Weeke, Peter

AU - Olesen, Jonas

AU - Torp-Pedersen, Christian

AU - Gislason, Gunnar Hilmar

PY - 2010/3/30

Y1 - 2010/3/30

N2 - OBJECTIVES: We studied the association of clopidogrel with mortality in acute myocardial infarction (AMI) patients with heart failure (HF) not receiving percutaneous coronary intervention (PCI).BACKGROUND: Use of clopidogrel after AMI is low in patients with HF, despite the fact that clopidogrel is associated with absolute mortality reduction in AMI patients.METHODS: All patients hospitalized with first-time AMI (2000 through 2005) and not undergoing PCI within 30 days from discharge were identified in national registers. Patients with HF treated with clopidogrel were matched by propensity score with patients not treated with clopidogrel. Similarly, 2 groups without HF were identified. Risks of all-cause death were obtained by the Kaplan-Meier method and Cox regression analyses.RESULTS: We identified 56,944 patients with first-time AMI. In the matched cohort with HF (n = 5,050) and a mean follow-up of 1.50 years (SD = 1.2), 709 (28.1%) and 812 (32.2%) deaths occurred in patients receiving and not receiving clopidogrel treatment, respectively (p = 0.002). The corresponding numbers for patients without HF (n = 6,092), with a mean follow-up of 2.05 years (SD = 1.3), were 285 (9.4%) and 294 (9.7%), respectively (p = 0.83). Patients with HF receiving clopidogrel demonstrated reduced mortality (hazard ratio: 0.86; 95% confidence interval: 0.78 to 0.95) compared with patients with HF not receiving clopidogrel. No difference was observed among patients without HF (hazard ratio: 0.98; 95% confidence interval: 0.83 to 1.16).CONCLUSIONS: Clopidogrel was associated with reduced mortality in patients with HF who do not undergo PCI after their first-time AMI, whereas this association was not apparent in patients without HF. Further studies of the benefit of clopidogrel in patients with HF and AMI are warranted.

AB - OBJECTIVES: We studied the association of clopidogrel with mortality in acute myocardial infarction (AMI) patients with heart failure (HF) not receiving percutaneous coronary intervention (PCI).BACKGROUND: Use of clopidogrel after AMI is low in patients with HF, despite the fact that clopidogrel is associated with absolute mortality reduction in AMI patients.METHODS: All patients hospitalized with first-time AMI (2000 through 2005) and not undergoing PCI within 30 days from discharge were identified in national registers. Patients with HF treated with clopidogrel were matched by propensity score with patients not treated with clopidogrel. Similarly, 2 groups without HF were identified. Risks of all-cause death were obtained by the Kaplan-Meier method and Cox regression analyses.RESULTS: We identified 56,944 patients with first-time AMI. In the matched cohort with HF (n = 5,050) and a mean follow-up of 1.50 years (SD = 1.2), 709 (28.1%) and 812 (32.2%) deaths occurred in patients receiving and not receiving clopidogrel treatment, respectively (p = 0.002). The corresponding numbers for patients without HF (n = 6,092), with a mean follow-up of 2.05 years (SD = 1.3), were 285 (9.4%) and 294 (9.7%), respectively (p = 0.83). Patients with HF receiving clopidogrel demonstrated reduced mortality (hazard ratio: 0.86; 95% confidence interval: 0.78 to 0.95) compared with patients with HF not receiving clopidogrel. No difference was observed among patients without HF (hazard ratio: 0.98; 95% confidence interval: 0.83 to 1.16).CONCLUSIONS: Clopidogrel was associated with reduced mortality in patients with HF who do not undergo PCI after their first-time AMI, whereas this association was not apparent in patients without HF. Further studies of the benefit of clopidogrel in patients with HF and AMI are warranted.

KW - Adult

KW - Aged

KW - Angioplasty, Balloon, Coronary

KW - Denmark

KW - Female

KW - Heart Failure

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Platelet Aggregation Inhibitors

KW - Proportional Hazards Models

KW - Survival Analysis

KW - Ticlopidine

KW - Journal Article

U2 - 10.1016/j.jacc.2009.11.057

DO - 10.1016/j.jacc.2009.11.057

M3 - Journal article

C2 - 20338489

VL - 55

SP - 1300

EP - 1307

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 13

ER -